Formation-destruction conditions of an interpolymer complex between a poly(acrylic acid) gel and linear poly(ethylene glycol) in methanol

Bekturov, Esen A.; Frolova, Vera A.; Mamytbekov, Galym K.

doi:10.1002/1521-3935(20000601)201:10<1031::aid-macp1031>3.0.co;2-6

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…It should be remembered here that PEG with molecular weight of 7500 or lower does not form any complexes with linear PAA . For the complexation between cross-linked PAA an linear PEG, there is a definite range of molecular weight of PEG where the stable complexes exist, below and above which the conditions of complete complexation will be disrupted . The lower limit of molecular weight of PEG is equal to 6000, and the upper limit is equal to 100 000.…”

Section: Resultsmentioning

confidence: 95%

“…The complex formation in the poly(carboxylic acid) networks is quite different from that in linear poly(carboxylic acid)s. The conformational changes of the poly(methacrylic acid) (PMAA) or poly(acrylic acid) (PAA) networks in PEG solution were reported in refs −7. It was shown that the absorption of PEG leads to the contraction of the gel of PMAA or PAA, and the relative mass of the gel can be lowered by a factor of 1.5−3.0.…”

Section: Introductionmentioning

confidence: 99%

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Shape Memory of Hydrogen-Bonded Polymer Network/Poly(ethylene glycol) Complexes

et al. 2004

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Because of a large difference in storage modulus below and above the glass transition temperature, poly(acrylic acid-co-methyl methacrylate)/poly(ethylene glycol) (P(AA-co-MMA)/PEG) complexes show shape memory properties with a recovery ratio of nearly reach 99%. Before the shape memory testing, it was necessary to determine the conformational changes of the P(AA-co-MMA) gel induced by complexation with linear PEG. It was found that both the concentration and molecular weight of PEG have a strong effect on the complexation with P(AA-co-MMA) gel. In such a system the minimum molecular weight of PEG required for the complex formation lowers to 1000.

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Shape Memory of Hydrogen-Bonded Polymer Network/Poly(ethylene glycol) Complexes

et al. 2004

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“…33,34 2.1.2 | Preparation of PEO-PAAc PEO that was dissolved in deionized water (1% v/v) was used to prepare PEO-PAAc nanogel. Different feed compositions of PEO and PAAc were used for polymerization to prepare PEO-PAAc through γ-radiation technique using γ-rays generated from 60 Co source at dose rate 1.9 kGy/h at room temperature. 33,35,36 2.2 | Conjugation of PEO-PAAc with FA Accurately, 30 mg of FA was directly added to 1 ml of the polymer nanogel followed by overnight stirring.…”

Section: Preparation Of Paacmentioning

confidence: 99%

“…56,57 The bounding between PAAc and PEO transformed from physically three-dimensional networks molecule into physically three-dimensional covalently bound networks molecule. [58][59][60] 3.2 | Factors affecting and controlling the size of PEO-PAAc nanogel…”

Section: Formation Of Peo-paac Nanogelmentioning

confidence: 99%

Polyethylene oxide–polyacrylic acid–folic acid (PEO‐PAAc) nanogel as a ^99mTc targeting receptor for cancer diagnostic imaging

Soliman

Sakr

Rashed

et al. 2021

Labelled Comp Radiopharmac

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Nanoparticles are frequently used as targeting delivery systems for therapeutic and diagnostic radiopharmaceuticals. Polyethylene oxide-polyacrylic acid (PEO-PAAc) nanogel was prepared via γ-radiation-induced polymerization. Variable factors affecting nanoparticles size were investigated. The nanogel was radiolabeled with the imaging radioisotope 99m Tc and finally conjugated with folic acid to target folate receptor actively. PEO-PAAc-folic acid gel was characterized by dynamic light scattering (DLS) and atomic force microscopy (AFM). Biodistribution was studied in normal mice and solid tumor-bearing mice via intravenous and intratumor injections of the radiolabeled PEO-PAAc-folic acid nanogel. Results of biodistribution showed high selective uptake of the prepared complex in tumor muscle compared with normal muscle for both intravenous and intratumor injections. The T/NT ratio was found to be 6.186 and 294.5 for intravenous and intratumor injections, respectively. Consequently, 99m Tc-PEO-PAAc-folic acid complex could be a promising agent for cancer diagnostic imaging.

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“…Also, the addition of 1.5 wt% PEG led to a high gel fraction at a low dose of 10 kGy. These hydrogels are assumed to have a semi-IPN structure, where PEG chains are diffused into the crosslinked network of PAA, forming a complex between PAA and PEG [24,25]. Inter-polymer complexes are known to be formed between a proton donor group like poly(carboxylic acids) and a proton acceptor group like PEG, poly(propylene oxide), poly(vinyl pyrolidone), poly(vinyl alcohol), etc.…”

Section: Gel Percent and Swelling Behaviormentioning

confidence: 99%

Poly(acrylic acid)/polyethylene glycol hygrogel prepared by using gamma-ray irradiation for mucosa adhesion

Nho

Park

Shin

et al. 2015

Journal of the Korean Physical Society

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A buccal delivery system provides a much milder environment for drug delivery compared to an oral delivery which presents a hostile environment for drugs, especially proteins and polypeptides, owing to acid hydrolysis. Local delivery in an oral cavity has particular applications in the treatment of toothaches, periodontal disease, and bacterial infections. Poly(acrylic acid) (PAA)-based hydrogels prepared using a chemical initiator have been attempted for a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, PAA and polyethylene glycol (PEG) were selected to prepare using a radiation process a bioadhesive hydrogel for adhesion to mucosal surfaces. PAA and PEG were dissolved in purified water to prepare a homogeneous PAA/PEG solution, and the solution was then irradiated using an electron beam at dose up to 70 kGy to make the hydrogels. Their physical properties, such as gel percent, swelling percent, and adhesive strength to mucosal surfaces, were investigated. In this experiment, various amounts of PEG were incorporated into the PAA to enhance the mucoadhesive property of the hydrogels. The effect of the molecular weight of PEG on the mucoadhesion was also examined.

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Formation-destruction conditions of an interpolymer complex between a poly(acrylic acid) gel and linear poly(ethylene glycol) in methanol

Cited by 9 publications

References 7 publications

Shape Memory of Hydrogen-Bonded Polymer Network/Poly(ethylene glycol) Complexes

Shape Memory of Hydrogen-Bonded Polymer Network/Poly(ethylene glycol) Complexes

Polyethylene oxide–polyacrylic acid–folic acid (PEO‐PAAc) nanogel as a ^99mTc targeting receptor for cancer diagnostic imaging

Poly(acrylic acid)/polyethylene glycol hygrogel prepared by using gamma-ray irradiation for mucosa adhesion

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Formation-destruction conditions of an interpolymer complex between a poly(acrylic acid) gel and linear poly(ethylene glycol) in methanol

Cited by 9 publications

References 7 publications

Shape Memory of Hydrogen-Bonded Polymer Network/Poly(ethylene glycol) Complexes

Shape Memory of Hydrogen-Bonded Polymer Network/Poly(ethylene glycol) Complexes

Polyethylene oxide–polyacrylic acid–folic acid (PEO‐PAAc) nanogel as a 99mTc targeting receptor for cancer diagnostic imaging

Poly(acrylic acid)/polyethylene glycol hygrogel prepared by using gamma-ray irradiation for mucosa adhesion

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Polyethylene oxide–polyacrylic acid–folic acid (PEO‐PAAc) nanogel as a ^99mTc targeting receptor for cancer diagnostic imaging