Formation, electrochemical and radical scavenging properties of novel ruthenium compounds with N, X-donor (X=O, N) heterocyclic chelators

Hepatoprotective Effects of a Ruthenium(II) Schiff Base Complex in Rats with Diet-Induced Prediabetes

“…Numerous Schiff base ruthenium(II) complexes have been isolated and their structural diversity have culminated into a wide spectrum of structure-activity of relationships 25 , 51 . For instance, the stereo-electronic features of the organic chelating ligands have been closely correlated to DNA-binding studies and cytotoxicity while the redox properties of the metal centre typically dictate their radical scavenging capabilities 25 , 51 , 52 . We speculate that the insulin-sensitizing effect of this compound may relate to the decreased SREBP-1c levels in ruthenium-treatment group.…”

Chemistry of 2-amino-4-oxo-4H-1-benzopyran-3-carboxaldehydes

“…19 In its reaction with transRuCl 2 (PPh 3 ) 2 in refluxing toluene under an open atmosphere to form the ruthenium complex 30, the Schiff base 29 behaves differently from the previous two imines 23 and 26; here the NH 2 group at the pyran 2-position functions as a vinylogous amide and consequently this amino nitrogen is covalently (not coordinately as in 23 and 26) bonded to the tripositive ruthenium arising from air oxidation of Ru(II). 20 Pictet-Spengler reaction of 5-hydroxydopamine hydrochloride 31 with the aldehyde 1 gives 1-(1-benzopyran-3-yl)isoquinoline derivative 32. 21 2-(N,N-Disubstituted amino)chromone-3-aldehydes 3 and 4 behave differently from their Nunsubstituted analogue 1 towards an aliphatic primary amine or diamine.…”