Formation of 4-<i>N</i>-Arylamino-1-butanol Derivatives from Aromatic Nitro Compounds via a Novel Palladium-Catalyzed Tetrahydrofuran Ring-Opening Reaction

Moran, Brian W.; Kenny, Peter T.M.

doi:10.1080/00397911.2011.582978

Cited by 2 publications

(1 citation statement)

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“…The formation of a THF hemi-aminal with anilines has previously been reported and this is believed to involve a radical mechanism. [27,28] It is also possible that this occurs with 2-API and subsequent ring opening of the THF hemi-aminal affords the tricyclic product (Figure 1). Its formation was avoided by the use of diethyl ether as a solvent in the lithium aluminium hydride reduction.…”

Section: Resultsmentioning

confidence: 99%

Identification of (2‐aminopropyl)indole positional isomers in forensic samples

Scott

Power

McDermott

et al. 2013

Drug Testing and Analysis

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In 2012, 5-(2-aminopropyl)indole (5-API, 5-IT) was reported by Norwegian authorities to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) via the Early Warning System (EWS). The 3- isomer, 3-(2-aminopropyl)indole (3-API, AMT, alpha-methyltryptamine), has been available on the recreational drugs market for a somewhat longer time, having first been reported to the EMCDDA by Finnish authorities in 2001. Both isomers are available from online vendors of 'legal highs'. Recently, three forensic drug cases (two tablets and one powder) were presented for routine analysis and the active constituent was tentatively identified as an API isomer. The six positional isomers (2-, 3-, 4-, 5-, 6- and 7-(2-aminopropyl)indoles) were synthesized and analyses by a combination gas chromatography-mass spectrometry (GC-MS), and liquid chromatography-mass spectrometry (LC-MS) showed that these could be readily discriminated thus facilitating the identification of 3-API in the tablets and 5-API in the powder. With exception of 5- and 6-APIs, which co-eluted, it was found possible to separate the isomers by GC without derivatization. LC separation also proved to be a feasible method for the discrimination of the isomers. Although the 2- and 7- isomers were not fully resolved by LC, it was found possible to distinguish them using their product ion spectra as the 2- isomer produced the m/z 132 fragment ion formed by loss of vinylamine, whereas the 7- isomer formed m/z 158 through loss of methylamine. In the synthesis 2-API, a novel tricyclic by-product was formed in an annulation reaction where the reaction solvent, tetrahydrofuran, was incorporated into the molecule.

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Section: Resultsmentioning

confidence: 99%