The results of the analysis of the influence of Izagri microelement fertilizers on safflower productivity in the forest-steppe conditions of the Middle Volga region are presented. The studies were conducted in 2020-2022 in the Penza region (experimental field of the Penza Research Institute of Agriculture). The object of the study was safflower of the Ershovsky 4 variety. The experiment consisted in pre-sowing seed treatment with Izagri series of microfertilizers. Izagri preparations were found to increase the growth force of seeds up to 1.21-1.57 cm, germination by 1.1-8.8%, safety of plants for harvesting by 0.5-6.2%. Against the background of fertilizer application, safflower productivity averaged 1.30-1.55 t/ha for 3 years, i.e. increased by 0.06-0.25 t/ha. The greatest effect was produced by Izagri Force and Izagri Vita, which helped to obtain a yield increase of 0.23-0.25 t/ha. The highest oil content of seeds was observed in the variants with Izagri Azot (29.85%) and Izagri Bor (30.04%): the increase was 2.7 and 3.0% respectively. Application of these preparations reduced seed huskiness to 37.7 and 37.9%, respectively. The largest seeds were formed in the variant with Izagri Vita - weight of 1 thousand seeds was 39.16 g. Treatment with Izagri Phosphorus and Izagri Vita gave a slight decrease in oleic acid content (to 9.94 and 9.62%). At the same time, the use of Izagri Vita maximized the amount of linoleic acid (up to 83.63%). After using Izagri Force, the concentration of this acid decreased to 81.88%. Based on the data obtained, it can be concluded that pre-sowing treatment of seeds with microfertilizers from Izagri line improves the quality indicators of oilseeds and can act as a method to increase the productivity of safflower.