Formation of aluminium and zinc complexes with picolinic acid. A potentiometric investigation

Jøns, Ole; Johansen, Erik Sylvest

doi:10.1016/s0020-1693(00)91893-0

Cited by 31 publications

(10 citation statements)

References 13 publications

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“…[1][2][3][4][5] Picolinic acid (2-pyridinecarboxylic acid) is a biologically important ligand incorporated into some enzymes, and it is an active agent in some drugs as well. [1][2][3][4][5] Picolinic acid (2-pyridinecarboxylic acid) is a biologically important ligand incorporated into some enzymes, and it is an active agent in some drugs as well.…”

Section: Introductionmentioning

confidence: 99%

X-ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex

et al. 2011

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A ruthenium(II)-arene complex with picolinic acid, [(η 6 -p-cymene)RuCl(pico)]·H 2 O, was prepared by the reaction of [(η 6 -p-cymene)RuCl 2 ] 2 with picolinic acid in a 1:2 molar ratio in 2-propanol. The compound was characterized by elemental analysis, and IR and NMR spectroscopy. X-ray diffraction analysis showed that the molecule adopts a "three-leg piano-stool" geometry, which is common for this type of complexes. The cytotoxic activity of the complex was tested in two human cancer cell lines HeLa (cervix) and FemX (melanoma) by MTT assay. The IC 50 values were at 82.0 and 36.2 µmol dm -3 for HeLa and FemX cells, respectively.

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Section: Introductionmentioning

confidence: 99%

X-ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex

et al. 2011

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“…The biological relevance of the complexes of zinc(II) formed with these ligands has been proved [2,[8][9][10][11][12][14][15][16]. The solid state structures of the applied bis complexes have been revealed [9][10][11], but, the solution speciations of these potential drugs remain relatively unexplored [17][18][19]. The original form of the candidate bis complexes most probably changes in the extracellular or intracellular biological fluids, and the carrier ligand may be partly or completely displaced by suitable endogenous zinc(II) binders.…”

Section: Introductionmentioning

confidence: 99%

An in vitro study of interactions between insulin-mimetic zinc(II) complexes and selected plasma components

Enyedy¹,

Horváth²,

Gajda‐Schrantz³

et al. 2006

Journal of Inorganic Biochemistry

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“…The distribution diagram of the various complexes formed in solution is shown in Fig 1. It can be seen that the dimeric species (2,2,0), (2,4,0) and (2,2,2) are dominant in the entire pH range studied. The concentration of mixed monomer (1,3,1) sharply increases at higher pH values (beyond 4.6) and this complex is probably a precursor of the species which eventually precipitate from the solution.…”

Section: Hydrolysis Of the A L U M I N I U M ( I I 1 ) I O Nmentioning

confidence: 90%

“…The tridecamer formation was not detected due to low degree of hydrolysis (m w 0.3) attained. Concerning the existence of the dimer, (2,2) in their recent publication [23] BROWN et al…”

Section: Hydrolysis Of the A L U M I N I U M ( I I 1 ) I O Nmentioning

confidence: 99%

Study of Equilibria in the Aluminium(III)‐Glycine and ‐Alanine Systems

Đjurdjević

Jelić

1989

Zeitschrift anorg allge chemie

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The formation of various hydrolytic and mixed hydrolytic complexes of the aluminium(III) ion in the presence of glycine and L‐alanine, has been studied in 0.5 mol dm−3 (Na)NO3 medium at 25deg;C, by emf method. The concentration ratios of amine acids to aluminium(III) were varied from 1 : 1 to 10 : 1. The least‐squares treatment of the data obtained, in the absence of the amino acids, indicates the formation of the dimer, [Al2(OH)2]4+, and monomer, [AlOH]2+, with the stability constants log β22 = −7.03 ± 0.03 and log β11 = −5.65 ± 0.09, respectively. At pH values higher then ∼4.0 formation of the trimer [Al3(OH)4]5+ (log β34 = −12.60 ± 0.08) becomes significant. In the presence of amino acids the evidence has been found for the formation of [Al2(OH)4]2+ (log β24 = −15.65 ± 0.09). Besides the formation of the pure hydrolytic complexes, equilibria in the title systems can be explained by assuming the main reaction products to have the compositions [Al(OH)3Gly] (log β131 = −7.53 ± 0.04), [Al2(OH)2(Gly)2] (log β222 = 6.56 ± 0.09) and [Al(OH)3Ala] (log β131 = −7.70 ± 0.03), [Al2(OH)2Ala2] (log β222 = 7.23 ± 0.07).

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Formation of aluminium and zinc complexes with picolinic acid. A potentiometric investigation

Cited by 31 publications

References 13 publications

X-ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex

X-ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex

An in vitro study of interactions between insulin-mimetic zinc(II) complexes and selected plasma components

Study of Equilibria in the Aluminium(III)‐Glycine and ‐Alanine Systems

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