Formation of Biodegradable Copolymeric Nanoparticles for Anticancer Drug Delivery

Anh, Nguyễn Thị Hoàng; Cương, Nguyễn Văn; Hoang, Nguyen Khanh

doi:10.1007/978-3-642-12020-6_51

Cited by 5 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the results, the antibacterial effect of m-PEG/PCL/eugenol was greater than the free eugenol at equal concentration and it was different against gram-positive and gram-negative bacteria (28). This nding can be interpreted by the improved properties of eugenol through loading into the polymeric nanoparticles in terms of antibacterial e ciency, stability, and drug solubility (29). The outcomes are consistent with past studies.…”

Section: Bacteria Growth Ratesupporting

confidence: 89%

Enhanced Antibacterial Activity of Eugenol-Loaded mPEG-PCL Nanoparticles in Eliminating Resistant Bacteria from Wastewater

Shajari

Rostamizadeh

Shapouri

et al. 2022

NANO

View full text Add to dashboard Cite

In this study, eugenol-loaded mPEG-PCL nanoparticles were used to improve the anti-bacterial properties of eugenol in an attempt to eliminate the resistant bacteria. The mPEG-PCL copolymer was prepared by ring-opening polymerization of [Formula: see text]-caprolactone monomer in the vicinity of a dry mPEG and a tin (II) octoate catalyst. Polymeric nanoparticles were prepared through the nanoprecipitation procedure. The particle size and zeta potential of mPEG-PCL/eugenol were found to be [Formula: see text][Formula: see text]nm and [Formula: see text][Formula: see text]mV, respectively. The polymeric nanoparticle structure was identified by AFM, FT-IR, and DSC techniques. To evaluate and compare the antibacterial efficiency of mPEG-PCL/eugenol with that of free eugenol, a turbidity assay was used in association with gram-positive and gram-negative bacteria. SEM images were taken from the bacteria before and after exposure to the mPEG-PCL/eugenol. The colony-forming unit per milliliter (CFU/mL) method was used to evaluate the performance of mPEG-PCL/eugenol on the growth rate of bacteria in hospital wastewater. The results showed that the mPEG-PCL/eugenol nanoparticles demonstrated an enormous antibacterial effect in connection with wild gram-negative bacteria strains at 40[Formula: see text][Formula: see text]M concentration and 37∘C. In the original hospital wastewater, mPEG-PCL/eugenol at the concentration of 0.125[Formula: see text][Formula: see text]M at 25∘C showed the largest decrease in the total microbial count.

show abstract

Section: Bacteria Growth Ratesupporting

confidence: 89%

Enhanced Antibacterial Activity of Eugenol-Loaded mPEG-PCL Nanoparticles in Eliminating Resistant Bacteria from Wastewater

Shajari

Rostamizadeh

Shapouri

et al. 2022

NANO

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…Recent studies of drug-loaded polymeric micelles showed enhanced characteristics of these materials, such as antibacterial efficiency, stability, drug solubility, and selective targeting [ 8 , 9 ]. Poly(ε-caprolactone) (PCL) has been studied as an ideal material for drug delivery because of its adjustable degradation time [ 8 , 10 , 11 ]. On the contrary, poly(ethylene glycol) (PEG) is a water-soluble, non-toxic molecule that has no antigenicity immunogenicity and can thus co-polymerize with ε-caprolactone (ε-CL) to take advantage of its improved bioavailability and biodegradation as well as mild toxicity [ 8 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Bactericidal Effect of Lauric Acid-Loaded PCL-PEG-PCL Nano-Sized Micelles on Skin Commensal Propionibacterium acnes

et al. 2016

View full text Add to dashboard Cite

Abstract:Acne is the over growth of the commensal bacteria Propionibacterium acnes (P. acnes) on human skin. Lauric acid (LA) has been investigated as an effective candidate to suppress the activity of P. acnes. Although LA is nearly insoluble in water, dimethyl sulfoxide (DMSO) has been reported to effectively solubilize LA. However, the toxicity of DMSO can limit the use of LA on the skin. In this study, LA-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) micelles (PCL-PEG-PCL) were developed to improve the bactericidal effect of free LA on P. acnes. The block copolymers mPEG-PCL and PCL-PEG-PCL with different molecular weights were synthesized and characterized using 1 H Nuclear Magnetic Resonance spectroscopy ( 1 H NMR), Fourier-transform infrared spectroscopy (FT-IR), Gel Permeation Chromatography (GPC), and Differential Scanning Calorimetry (DSC). In the presence of LA, mPEG-PCL diblock copolymers did not self-assemble into nano-sized micelles. On the contrary, the average particle sizes of the PCL-PEG-PCL micelles ranged from 50-198 nm for blank micelles and 27-89 nm for LA-loaded micelles. The drug loading content increased as the molecular weight of PCL-PEG-PCL polymer increased. Additionally, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of free LA were 20 and 80 µg/mL, respectively. The MICs and MBCs of the micelles decreased to 10 and 40 µg/mL, respectively. This study demonstrated that the LA-loaded micelles are a potential treatment for acne.

show abstract

“…These characteristics included gel attributes, pharmacokinetics, morphology, effectiveness against cancer, and immune-histopathology. A more recent study demonstrated that several nanocarriers, including the bio-nano-capsule-liposome nanocarrier [ 134 ], poly(benzyl-L-aspartate)-co-[N-(3-aminopropyl) imidazole-L-aspartamide]-poly(ethylene glycol) [ 135 ], polysaccharide-based carriers [ 136 ], and poly(aspartic acid-graft Epsilon-caprolactone polymerized with poly(ethylene glycol) [ 137 ], were shown to be safe in vivo when being used to treat intestinal inflammation and malignancies. Although a wide range of nanocarriers are being developed, several of them are currently going through sophisticated clinical testing.…”

Section: Safety Evaluation Of Lipid-based Nanoparticles Encapsulating...mentioning

confidence: 99%

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Patel,

Garala,

Singh

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of action limited their pharmaceutical applications. However, those can be improved using nanotechnology to create various drug delivery systems, including lipid-based nanoparticles, to adjust the compounds’ physicochemical properties and pharmacokinetic profile. Because of the enormous technical advancements made in the fundamental sciences and the physical and chemical manipulation of individual atoms and molecules, the subject of nanotechnology has experienced revolutionary growth. By fabricating certain functionalized particles, nanotechnology opens an innovative horizon in research and development for overcoming restrictions, including traditional medication administration systems. Nanotechnology-driven bioactive compounds are certain to have a high impact and clinical value for current and future uses. Lipid-based nanotechnologies were shown to deliver a range of naturally occurring bioactive compounds with decent entrapment potential and stability, a successfully controlled release, increased bioavailability, and intriguing therapeutic activity. This review outlines bioactive compounds such as paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, and oridonin, fortified within either a natural or synthetic lipid-based drug delivery system based on nanotechnology and their evaluation and clinical considerations.

show abstract

Formation of Biodegradable Copolymeric Nanoparticles for Anticancer Drug Delivery

Cited by 5 publications

References 8 publications

Enhanced Antibacterial Activity of Eugenol-Loaded mPEG-PCL Nanoparticles in Eliminating Resistant Bacteria from Wastewater

Enhanced Antibacterial Activity of Eugenol-Loaded mPEG-PCL Nanoparticles in Eliminating Resistant Bacteria from Wastewater

Bactericidal Effect of Lauric Acid-Loaded PCL-PEG-PCL Nano-Sized Micelles on Skin Commensal Propionibacterium acnes

Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

Contact Info

Product

Resources

About