Formation of Cu(II)–brazilin complex in the presence of DNA and its activities as chemical nuclease

Yun, Jaemin; Lee, Hyun Mee; Kim, Seog K.; Lee, Sun-Young; Lee, Chong Soon; Cho, Tae-Sub

doi:10.1016/j.jinorgbio.2006.04.013

Cited by 9 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brazilin is the main homoisoflavonoid constituent found in the CS heartwood, which is well known as the natural red color dye for staining [3,16] . Brazilin also exhibit different industrial applications.…”

Section: Brazilinmentioning

confidence: 99%

“…Hwang et al [52] Nuclease activity Yun et al [16] Matrix metalloproteinase inhibition Toegel et al; [1] Lee et al [7] individuals. Fructose-2,6-bisphosphate (F-2,6BP) a gluconeogenic intermediate, plays a critical role in hepatic glucose output by regulating gluconeogenisis and glycolysis in the liver [8] .…”

Section: Lipase Inhibitionmentioning

confidence: 99%

“…Brazilin form a complex with Cu (Ⅱ) in the presence as well as the absence of DNA. The Cu (Ⅱ)-brazilin complex exhibited the nuclease activity for the pBR322 supercoiled DNA, converting supercoiled forms to nicked form [16]. As the concentration of both brazilin and Cu (Ⅱ) increased from 50 to 150 mM, the activity increased.…”

Section: Miscellaneousmentioning

confidence: 99%

“…In traditional Chinese medicine, brazilin is used for treatment of increased blood circulation, promotes menstruation and exhibit analgesic and anti-inflammatory potentials [4] . Brazilin have been reported to possess various biological activities including antibacterial [5] , anti-inflammatory [6] , anti-photoaging [7] , hypoglycemic [8,9] , vasorelaxant [10,11] , anti-allergic [12] , antiacne [13,14] , antioxidant [15] and nuclease activity [16] .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Nirmal

Rajput

Prasad³

et al. 2015

Asian Pacific Journal of Tropical Medicine

231

153

View full text Add to dashboard Cite

Caesalpinia sappan L. (CS) is a plant of Leguminosae family, commonly known as Brazil or Sappan wood. CS is distributed in Southeast Asia and its dried heartwood has been used as traditional ingredient of food or beverages and has a wide variety of medicinal properties. Higher extraction yield of CS wood was achieved with 95% ethanol for 2 h. Chemical constituent's investigation of sappan wood resulted in the isolation of various structural types of phenolic components including one xanthone, one coumarin, three chalcones, two flavones three homoisoflavonoids and brazilin. Brazilin [(6a S-cis)-7, 11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)- tetrol], a major and active compound found in CS heartwood. Most of the folkloric uses of brazilin were validated by the scientific studies such as antioxidant, antibacterial, anti-inflammatory, anti-photoaging, hypoglycemic, vasorelaxant, hepatoprotective and anti-acne activity. CS heartwood extract is safe and did not produce any acute or subacute toxicity in both male and female rats. Brazilin is the safe natural compound having potential to develop as a medicinal compound with application in food, beverage, cosmetics and pharmaceutical industries to screen its clinical use in modern medicine. The information gained could provide the important and potential approach for pharmaceutical researcher to implicate the knowledge of brazilin in the formulation of new drug and to reveal therapeutic and gaps requiring future research opportunities. More studies are needed to evaluate the potential application of brazilin as preservative and coloring agent in food processing industries.

show abstract

Section: Brazilinmentioning

confidence: 99%

Section: Lipase Inhibitionmentioning

confidence: 99%

Section: Miscellaneousmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Nirmal

Rajput

Prasad³

et al. 2015

Asian Pacific Journal of Tropical Medicine

231

153

View full text Add to dashboard Cite

show abstract

“…www.nature.com/scientificreports/ inexpensiveness of the plant source, it has also been used as a colorant to yield red color in traditional foods and beverages in several Asian countries 4,[20][21][22][23][24] .…”

mentioning

confidence: 99%

Color and molecular structure alterations of brazilein extracted from Caesalpinia sappan L. under different pH and heating conditions

Ngamwonglumlert

Devahastin

Chiewchan

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Brazilein extract from sappan wood (Caesalpinia sappan L.) has potential for use as natural food colorant since it has no unique flavor and taste. Although brazilein has long been applied in several traditional foods and beverages, information on its stability, which is of importance for practical application, is still limited. In this work, brazilein was isolated from sappan wood; its purity was confirmed by nuclear magnetic resonance spectroscopy. Relations between molecular structures and color as well as thermal stabilities of brazilein in aqueous solutions at pH 3, 7 and 9 were for the first time investigated. At the lowest pH, zero net-charge structure of brazilein, which exhibited yellow color, was predominantly found. The deprotonated and fully deprotonated structures of brazilein, which exhibited orange and red colors, respectively, were found when pH of the aqueous solutions increased. The forms of brazilein existing at the higher pH suffered extensive degradation upon heating, while the form existing at the lowest pH possessed higher stability. Heat-induced deprotonation and degradation were confirmed by UV-visible and Fourier-transform infrared spectra as well as losses of brazilein content. Sappan (Caesalpinia sappan L.), which has several such local names as Buckham wood in English, Bois de sappan in French, Pau de sappan in Polish, Sappanholz in German, Su mu in Chinese, Suo in Japanese and Fang in Thai, is a wood in the family Leguminosae. This wood is naturally available throughout Asia, including China, Japan and Thailand. Due to its several valuable functions, this wood plant is also nowadays cultivated in various other regions of the world, including Africa, Europe as well as North and South Americas. Dried heartwood of sappan has long been used as herbal medicines as it contains many phytochemicals and bioactive compounds 1-5. The biological abilities of the wood extract in terms of antiacne 6 , anti-bacterial 7,8 , anticancer 9 , antidiabetic 10 , antidiarrhea 11 , antiinflammatory 12-14 , antioxidant 15 and anti-photoaging 16 activities have been demonstrated by a number of researchers. The major active ingredient of sappan is brazilin, which is a colorless phenolic compound consisting of two aromatic rings, one pyrone and one five-membered ring. Based on its molecular structure, brazilin is identified as a neoflavonoid. However, hydroxyl group in the brazilin structure is easily oxidized and can change into carbonyl group, resulting in the structural transformation and formation of brazilein, which is a colored compound 17-19. Brazilein has indeed widely been used as a natural colorant; sappan extract containing brazilein has traditionally been used in the painting of books as well as in the dyeing of silk and wool. Since an aqueous extract of sappan possesses many beneficial properties over other red-color pigments, e.g.

show abstract

Sources, Application, and Analysis of Natural Colorants: An Indian Perspective

Samanta

Singhee

2023

Handbook of Natural Colorants

View full text Add to dashboard Cite

Formation of Cu(II)–brazilin complex in the presence of DNA and its activities as chemical nuclease

Cited by 9 publications

References 19 publications

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Color and molecular structure alterations of brazilein extracted from Caesalpinia sappan L. under different pH and heating conditions

Sources, Application, and Analysis of Natural Colorants: An Indian Perspective

Contact Info

Product

Resources

About