Formation of Electric Biosignals

Kaniušas, Eugenijus

doi:10.1007/978-3-319-74917-4_2

Cited by 4 publications

(21 citation statements)

References 58 publications

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“…Needles should reside close to the local aVN fibers or their endings (Bermejo et al, 2017) to guarantee their suprathreshold stimulation but not too close to avoid their cathodic block [characterized by the inhibited propagation of excitation (Kaniusas, 2019)]. Then the maximum recruitment efficiency can be attained for a given stimulation pattern (Tarnaud et al, 2018).…”

Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

“…Auricular vagus nerve stimulation of a percept-matched and subjectively comfortable intensity is preferred to reach therapeutic target (Busch et al, 2012; Napadow et al, 2012) which is a strong function of the stimulation pattern (Bald, 2010; Kaniusas, 2019). For instance, Deuchars et al (2017) prefer intensities which are slightly below the subjective perception level.…”

Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

“…Here relatively high stimulation frequencies of 20–25 Hz are required for the peripheral electrical stimulation of the parasympathetic system, whereas low frequencies of 0.5–10 Hz are required for sympathetic system. High frequencies show narrow depolarizing half-period durations and thus are only able to recruit easily excitable thick nerve fibers (Kaniusas, 2019), such as myelinated Aβ fibers, which may indirectly activate the parasympathetic system. In contrast, wide depolarizing half-periods of low frequencies are required to recruit thin nerve fibers, such as myelinated Aδ or non-myelinated C fibers, activating usually the sympathetic system.…”

Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

“…The pulse width usually determines the type of fibers to be excited. That is, short pulses recruit easily excitable thick fibers only while elongated pulses recruit both thick and thin fibers (Kaniusas, 2019). For the transcutaneous aVNS, authors in Badran et al (2018b) show that different stimulation parameters yield different responses in the heart rate (systemic body parameter), whereas Polak et al (2009) use vagus somatosensory evoked potentials to optimize parameters.…”

Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

“…The efficiency of stimulation can be increased with bursted stimulation (Martlé et al, 2014; Szabó et al, 2017); e.g., with bursts of short pulses every second (Reilly and Diamant, 2011; Kampusch et al, 2013; Kaniusas, 2019). A single or a few action impulses triggered at the sensory aVN endings in response to single electrical stimuli are less likely to influence systemic regulation or brain activity (e.g., the sympathovagal balance), rather than a rhythmic sequence of these impulses.…”

Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

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Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective

et al. 2019

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Electrical stimulation of the auricular vagus nerve (aVNS) is an emerging electroceutical technology in the field of bioelectronic medicine with applications in therapy. Artificial modulation of the afferent vagus nerve – a powerful entrance to the brain – affects a large number of physiological processes implicating interactions between the brain and body. Engineering aspects of aVNS determine its efficiency in application. The relevant safety and regulatory issues need to be appropriately addressed. In particular, in silico modeling acts as a tool for aVNS optimization. The evolution of personalized electroceuticals using novel architectures of the closed-loop aVNS paradigms with biofeedback can be expected to optimally meet therapy needs. For the first time, two international workshops on aVNS have been held in Warsaw and Vienna in 2017 within the scope of EU COST Action “European network for innovative uses of EMFs in biomedical applications (BM1309).” Both workshops focused critically on the driving physiological mechanisms of aVNS, its experimental and clinical studies in animals and humans, in silico aVNS studies, technological advancements, and regulatory barriers. The results of the workshops are covered in two reviews, covering physiological and engineering aspects. The present review summarizes on engineering aspects – a discussion of physiological aspects is provided by our accompanying article ( Kaniusas et al., 2019 ). Both reviews build a reasonable bridge from the rationale of aVNS as a therapeutic tool to current research lines, all of them being highly relevant for the promising aVNS technology to reach the patient.

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Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

Section: Electrical Stimulation Of Vnmentioning

confidence: 99%

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Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective

et al. 2019

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Scalable two-tier protruding micro-/nano-optoelectrode arrays with hybrid optical-electrical modalities by hierarchical modular design

et al. 2022

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International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)

Farmer

Strzelczyk

Finisguerra

et al. 2021

Front. Hum. Neurosci.

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Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation(VNS) and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice.

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Formation of Electric Biosignals

Cited by 4 publications

References 58 publications

Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective

Current Directions in the Auricular Vagus Nerve Stimulation II – An Engineering Perspective

Scalable two-tier protruding micro-/nano-optoelectrode arrays with hybrid optical-electrical modalities by hierarchical modular design

International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)

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