Formation of hydrated layers in PMMA thin films in aqueous solution

Akers, Peter; Nelson, Andrew; Williams, David E.; McGillivray, Duncan J.

doi:10.1016/j.apsusc.2015.06.199

Cited by 12 publications

(10 citation statements)

References 24 publications

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“…The volume fractions of all films are plotted as functions of distance from the Si/SiOx wafer or grafting surface, illustrating the structural information obtained from neutron reflectometry. The observed partially hydrated PMMA layer at the SiOx interface and the low solvation of the PMMA layer has been described previously . The thickness of protein layers exhibit minor variations between APTES and PMMA, and the APTES-PEG layers have higher hydration (Figure C,D) when compared with that of the PMMA-PEG layers (Figure A,B).…”

Section: Resultssupporting

confidence: 82%

“…The observed partially hydrated PMMA layer at the SiOx interface and the low solvation of the PMMA layer has been described previously. 32 The thickness of protein layers exhibit minor variations between APTES and PMMA, and the APTES-PEG layers have higher hydration (Figure 2C,D) when compared with that of the PMMA-PEG layers (Figure A,B). In general, )), the thicknesses of the protein layers confirm that an approximate protein monolayer was formed on each surface.…”

Section: ■ Resultsmentioning

confidence: 94%

“…nSLD values for the PMMA and PEG layers were calculated from the bulk densities of the molecules and were fixed during fitting at the calculated values. Recent studies of PMMA and PMMA–PEG thin films have shown that the nSLD values used are appropriate and characterize the layers well. Since the chemical composition of APTES layers can vary because of variations in the extent of hydrolysis during deposition reactions, the nSLD of APTES layers was not fixed during data fitting.…”

Section: Methodsmentioning

confidence: 99%

“…Deposition of PMMA and APTES Films. PMMA (∼120 kDa) films were prepared following a previously used procedure, 32 in which PMMA was suspended in toluene at 2.5 g L −1 and heated to 45 °C until no solid particles were visible. The solution was sonicated for 15 min using an Elmasonic S 30 ultrasonic bath (Elma Schmidbauer GmbH, Singen, Germany) and filtered through a 0.2 μM pore size PTFE filter (Raylab Ltd., Auckland, New Zealand).…”

Section: ■ Introductionmentioning

confidence: 99%

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Using Neutron Reflectometry to Characterize Antimicrobial Protein Surface Coatings

et al. 2017

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Understanding the interaction of adsorbed or covalently immobilized proteins with solid substrates at the molecular level guides the successful design of functionalized surfaces used in biomedical applications. In this report, neutron reflectometry (NR) was used to characterize the structure of surface-attached antimicrobial protein films, with antimicrobial activity assessed using an adaption of the Japanese Industrial Standard Test JIS Z 2801. NR allowed parameters influencing bioactivity to be measured at nanometer resolution and for conclusions about structural characteristics relating to bioactivity to be drawn. Hydramacin-1 (HM-1) and lysozyme were covalently attached to poly(methyl methacrylate) (PMMA) and 3-aminopropyltriethoxysilane (APTES) films in the presence and absence of a four-unit poly(ethylene glycol) PEG-based spacer and measured using NR, followed by antimicrobial assays. APTES-PEG-protein films were structurally unique, with a layer of 80% water directly beneath the protein layer, and were the only films that displayed antimicrobial activity against Escherichia coli and Bacillus subtilis. The hydration content of these films combined with the subtle difference in the PEG layer thickness of APTES versus PMMA films played a role in defining antimicrobial activity of the prepared surface coatings.

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Section: Resultssupporting

confidence: 82%

Section: ■ Resultsmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Using Neutron Reflectometry to Characterize Antimicrobial Protein Surface Coatings

et al. 2017

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“…In these applications, a nonsolvent is used as a liquid. However, the aggregation states and physical properties of polymer chains are generally affected by the sorption of even nonsolvent molecules, especially in the interfacial region. − For example, the outermost surface of a typical glassy polymer, poly(methyl methacrylate) (PMMA), in contact with nonsolvents such as methanol and water is diffused compared to the air-facing surface because chain segments can be partially dissolved in the liquid phase. − Also, in some cases, a swollen layer is formed just beneath the diffused interface, depending on the type of nonsolvents. , A similar phenomenon also occurs for other polymers such as acrylate-, − vinyl ether-, − ethylene oxide-, , and oxazoline-based , polymers in contact with water as a nonsolvent. Consequently, chain dynamics at the nonsolvent interface are well enhanced, ,,− drastically affecting the material’s functions. − …”

Section: Introductionmentioning

confidence: 99%

Modification of a Polymer Surface by Partial Swelling Using Nonsolvents

et al. 2021

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Surface modification without changing the physical properties in the bulk is of pivotal importance for the development of polymers as devices. We recently proposed a simple surface functionalization method for polymer films by partial swelling using a nonsolvent and demonstrated the incorporation of poly(2-methoxyethyl acrylate) (PMEA), which has an excellent antibiofouling ability, only into the outermost region of a poly(methyl methacrylate) (PMMA) film. We here extend this technology to another versatile polymer, polystyrene (PS). In this case, PS and PMEA have different solubility parameters making it difficult to select a suitable solvent, which is a nonsolvent for PS and a good solvent for PMEA, unlike the combination of PMMA with PMEA. Thus, such a solvent was first sought by examining the swelling behavior of PS films in contact with various alcohols. Once a mixed solvent of methanol/1-butanol (50/50 (v/v)) was chosen, PMEA chains could be successfully incorporated at the outermost region of the PS film. Atomic force microscopy in conjunction with neutron reflectivity revealed that chains of PMEA incorporated in the PS surface region were well swollen in water. This leads to an excellent ability to suppress the adhesion of platelets on the PS film.

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Applications of Polyvinylchloride (PVC)/Thermoplastic Nano-, Micro- and Macroblends

Grosu

2021

Springer Series on Polymer and Composite Materials

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Formation of hydrated layers in PMMA thin films in aqueous solution

Cited by 12 publications

References 24 publications

Using Neutron Reflectometry to Characterize Antimicrobial Protein Surface Coatings

Using Neutron Reflectometry to Characterize Antimicrobial Protein Surface Coatings

Modification of a Polymer Surface by Partial Swelling Using Nonsolvents

Applications of Polyvinylchloride (PVC)/Thermoplastic Nano-, Micro- and Macroblends

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