Formation of ionic depletion/enrichment zones in a hybrid micro-/nano-channel

Huang, Kuan-Da; Yang, Ruey-Jen

doi:10.1007/s10404-008-0281-9

Cited by 38 publications

(44 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our early study, we discussed the flow field within the depletion region by experimental and numerical ways. Results showed a fieldamplified effect within the depletion zone induces a rapid electroosmotic flow, which in turn prompts the generation of vortex flow structures within the depletion zone [17].…”

Section: Introductionmentioning

confidence: 99%

A nanochannel‐based concentrator utilizing the concentration polarization effect

Huang

Yang

2008

Electrophoresis

Self Cite

View full text Add to dashboard Cite

This study develops a microfluidic device comprising two microchannels connected by a nanochannel in which the sample is concentrated via an ionic depletion effect. Using Rhodamine 6G dye for visualization purposes, it is shown that through an appropriate manipulation of the external potentials applied to the reservoirs of the device, an ionic depletion region with an electrical conductivity around 50 times lower than that of the buffer solution can be induced on the anodic side of the nanochannel. Furthermore, via an appropriate time-based switching of the external electrical potentials, the sample species can be concentrated close to the conductivity ratio within an interval of 1 min. Finally, it is shown that by varying the configuration of the electrical potentials applied to the device reservoirs, the concentrated sample can be delivered either to a single outlet reservoir or to multiple reservoirs.

show abstract

Section: Introductionmentioning

confidence: 99%

A nanochannel‐based concentrator utilizing the concentration polarization effect

Huang

Yang

2008

Electrophoresis

Self Cite

View full text Add to dashboard Cite

show abstract

“…20,26 Continuum level modeling has been applied successfully at microscale to numerous problems, such as multiphase heat exchangers, 27 microbubble generation for biomedical applications, 28 and electrokinetic micromixers. 29,30 CONTINUUM AND MOLECULAR MODELS…”

Section: Governing Equationsmentioning

confidence: 99%

Computational Strategies for Micro‐ and Nanofluid Dynamics

Drikakis

Asproulis

Shapiro

et al. 2010

Microfluidic Devices in Nanotechnology

View full text Add to dashboard Cite

“…Some marks are distributed on both glass plates for alignment too. Recently, Huang and Yang (2008) group reported a similar method of forming the glass micronanofluidic chip. Instead of the cross-form microchip in their report, the U-form layout is adopted in our work.…”

Section: Introductionmentioning

confidence: 97%

Research on forming and application of U-form glass micro-nanofluidic chip with long nanochannels

Wen

Liu

et al. 2009

Microfluid Nanofluid

View full text Add to dashboard Cite

The forming process of U-form glass micronanofluidic chip with long nanochannels is presented in this paper, in which the fabrication of channels and the assembly of plates are included. The micro-nanofluidic chip is composed of two glass plates in which there are microchannels and nanochannels, respectively. This chip can be used for trace sample enrichment, molecule filtration, and sample separation, etc. In fabrication process, the two-step photolithograph on one wafer is often required in early papers, as nano and micro structure designed in one plate have different depths. In this paper, the channels in micro-nanofluidic chip are designed in two glass plates instead of in one wafer. The nanochannels and microchannels are, respectively, formed on plates using wet etching and two-step photolithograph on one wafer is not required. Since the channels are formed, the upper plate and the bottom plate are assembled together by alignment, preconnection and thermal bonding orderly. Firstly these plates are aligned with the cross-marks on an inverted microscope. The aqueous film between plates is controlled to decrease the static friction force for accurate adjustment. Then the adhesion strength of connection is enhanced with semi-dry status for limiting movement from slight inclining and shaking. At last, the bottom plate and the upper one are irreversibly linked together with thermal bonding. The heating period and max temperature of thermal bonding are optimized to eliminate thermal stress gradient and the size shrinking. With the micro-nanofluidic chip, the 1 lM fluorescein isothiocyanate in 10 mM PBS buffer is concentrated successfully. The sample concentrating factor of light intensity varies from 2.2 to 8.4 with applied voltages between 300 and 2,000 V. The switch effect and the instability effect in concentrating process are described and analyzed too.

show abstract

Formation of ionic depletion/enrichment zones in a hybrid micro-/nano-channel

Cited by 38 publications

References 21 publications

A nanochannel‐based concentrator utilizing the concentration polarization effect

A nanochannel‐based concentrator utilizing the concentration polarization effect

Computational Strategies for Micro‐ and Nanofluid Dynamics

Research on forming and application of U-form glass micro-nanofluidic chip with long nanochannels

Contact Info

Product

Resources

About