Formation of maghemite nanostructures in polyol: tuning the particle size <i>via</i> the precursor stoichiometry

Wetegrove, Marcel; Witte, Kerstin; Bodnar, Wiktor; Pfahl, Dan-Eric; Springer, Armin; Schell, Norbert; Westphal, Fritz; Burkel, E.

doi:10.1039/c8ce02115e

Cited by 11 publications

(16 citation statements)

References 37 publications

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“…This correlation was verified by several studies which conclude that nanoflowers are excellent candidates for MPI. [ 38,39 ]…”

Section: Discussionmentioning

confidence: 99%

“…Recently, however, it was demonstrated that in case of magnetic hyperthermia (and also MPI, MRI) defect-rich iron oxide nanoparticles can actually outperform their defect-free counterparts. [32][33][34][35][36][37][38][39] Motivated by these striking results, here, we will remove the common stigma of defects in iron oxide nanoparticles. At first, we discuss recent studies on positive impacts of defects and disorder on magnetic hyperthermia performance of iron oxide nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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Embracing Defects and Disorder in Magnetic Nanoparticles

2021

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Iron oxide nanoparticles have tremendous scientific and technological potential in a broad range of technologies, from energy applications to biomedicine. To improve their performance, single‐crystalline and defect‐free nanoparticles have thus far been aspired. However, in several recent studies, defect‐rich nanoparticles outperform their defect‐free counterparts in magnetic hyperthermia and magnetic particle imaging (MPI). Here, an overview on the state‐of‐the‐art of design and characterization of defects and resulting spin disorder in magnetic nanoparticles is presented with a focus on iron oxide nanoparticles. The beneficial impact of defects and disorder on intracellular magnetic hyperthermia performance of magnetic nanoparticles for drug delivery and cancer therapy is emphasized. Defect‐engineering in iron oxide nanoparticles emerges to become an alternative approach to tailor their magnetic properties for biomedicine, as it is already common practice in established systems such as semiconductors and emerging fields including perovskite solar cells. Finally, perspectives and thoughts are given on how to deliberately induce defects in iron oxide nanoparticles and their potential implications for magnetic tracers to monitor cell therapy and immunotherapy by MPI.

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“…This correlation was verified by several studies which conclude that nanoflowers are excellent candidates for MPI. [ 38,39 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Embracing Defects and Disorder in Magnetic Nanoparticles

2021

View full text Add to dashboard Cite

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“…Moreover, thanks to their relatively high boiling points, they also offer a wide range of operating temperatures for producing inorganic compounds [142]. This chemical approach has been described for the preparation of well-defined shapes (spheres, clusters, raspberry, multicore flowers) and controlled sizes (5 -50 nm) of oxides nano-and microparticles [8,[143][144][145][146][147][148][149][150][151][152][153]. The resulting nanoparticles in the polyol process are highly crystalline with a high magnetic saturation.…”

Section: Synthesis Of Magnetic Nanoparticlesmentioning

confidence: 99%

Magnetic nanoparticles in regenerative medicine: what of their fate and impact in stem cells?

Walle

Perez

Abou‐Hassan

et al. 2020

Materials Today Nano

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With advancing developments over the use of magnetic nanoparticles in biomedical engineering, and more specifically cell-based therapies, the question of their fate and impact once internalized within (stem) cells remains crucial. After highlighting the regenerative medicine applications based on magnetic nanoparticles, this review documents their potential cytotoxicity and, more importantly, underscores their valuable features for stem cell differentiation. It then focuses on the transformations magnetic nanoparticles might experience in cells, mainly consisting in their progressive degradation, and assesses the practical pitfalls related to this degradation. First, it may result in a loss of long-term theranostic potential, and second, it necessitates an adaptation of the cell metabolism to the released iron. Overall, this review demonstrates that magnetic nanoparticles present undeniable interest for stem cell-based biomedical applications; however, each nanoparticle/cell system must be carefully considered for a safe medical use. It also clearly evidences that the biodegradation of the nanoparticles and the cell response to the released iron must be systematically assessed.

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“…The role of water was studied by Hemery et al [ 93 ], when its importance was revealed by inability of the anhydrous iron chloride to produce magnetic particles [ 93 ]. The impact of stoichiometry in polyol synthesis has been studied by Wetegrove et al [ 94 ], showing that the increase in Fe 3+ concentration forms larger crystallites and the increase in Fe 2+ content promotes nucleation [ 94 ].…”

Section: Methods For the Synthesis Of Ionpsmentioning

confidence: 99%

Magnetic Nanoparticles as MRI Contrast Agents

et al. 2020

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Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.

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Formation of maghemite nanostructures in polyol: tuning the particle size via the precursor stoichiometry

Abstract: Investigating the polyol-assisted synthesis of maghemite nanoflowers, a strong impact of the iron precursor stoichiometry on physical properties is found.

Cited by 11 publications

References 37 publications

Embracing Defects and Disorder in Magnetic Nanoparticles

Embracing Defects and Disorder in Magnetic Nanoparticles

Magnetic nanoparticles in regenerative medicine: what of their fate and impact in stem cells?

Magnetic Nanoparticles as MRI Contrast Agents

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