2011
DOI: 10.1002/jms.1916
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Formation of metal complex ions from amino acid in the presence of Li+, Na+ and K+ by electrospray ionization: metal replacement of hydrogen in the ligands

Abstract: Alkali metal cations easily form complexes with proteins in biological systems; understanding amino acid clusters with these cations can provide useful insight into their behaviors at the molecular level including diagnosis and therapy of related diseases. For the purpose of characterization of basic interaction between amino acids and alkali metal, each of the 20 naturally occurring amino acids were ionized in the presence of lithium, sodium and potassium cations by electrospray ionization, and the resulting … Show more

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Cited by 12 publications
(6 citation statements)
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“…4 The metal complexation of the bioactive ligands has been used as an analytical tool to enhance the characterization of bioactive molecules which is otherwise complicated. 5 Spectroscopic data and the X-ray analysis show that the N7 atom of the purine or N3 of pyrimidine was the preferential site of metal binding during the metal-DNA interaction. 6 Therefore the study of these metal ions interaction with N substituted heteroaromatics is of fundamental importance to understand various biological processes.…”
Section: Introductionmentioning
confidence: 96%
“…4 The metal complexation of the bioactive ligands has been used as an analytical tool to enhance the characterization of bioactive molecules which is otherwise complicated. 5 Spectroscopic data and the X-ray analysis show that the N7 atom of the purine or N3 of pyrimidine was the preferential site of metal binding during the metal-DNA interaction. 6 Therefore the study of these metal ions interaction with N substituted heteroaromatics is of fundamental importance to understand various biological processes.…”
Section: Introductionmentioning
confidence: 96%
“…However, some metalated amino acids may exhibit so called salt bridge (SB) structures as their low energy conformations [11,18,21,22,27], while SB or zwitterions structures are often absent for free amino acids. Therefore, the aforementioned trial structures are only reliable for determining low energy charge solvated (CS) structures of metalated amino acid.…”
Section: Methodsmentioning
confidence: 99%
“…6 Attention has also been paid to small-molecule association in solution. Numerous papers have described the formation of complexes of different macrocycles (crown ethers, cryptands, glymes), 7 cyclodextrins, 8 calixarene, 9 aminoacids 10 and guanidinium ions 11 with various guests.…”
Section: Introductionmentioning
confidence: 99%