Formation of mucosal polyps in the nasal and maxillary sinus cavities by infection

Norlander, Tomas; Fukami, Masaya; Westrin, Karl Magnus; Stierna, Pontus; Carlsöö, Bengt

doi:10.1177/019459989310900322

Cited by 60 publications

(51 citation statements)

References 13 publications

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“…Streptococcus pneumoniae, Staphylococcus aureus, and Bacteroides fragilis are the most frequently used bacteria to induce sinusitis [7]. In the present study Staphylococcus aureus was used to induce sinusitis.…”

Section: Discussionmentioning

confidence: 91%

Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis

Özcan¹,

Özcan²,

Selçuk³

et al. 2011

Indian J Otolaryngol Head Neck Surg

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The aim of this study was to investigate and compare histopathological and computerized tomographic (CT) findings of experimental acute sinusitis in an animal model. The noses of five healthy rabbits were inoculated with a gelatin sponge impregnated with a solution containing Staphylococcus aureus, and one healthy rabbit acted as the control. The animals were sacrificed on the tenth day, following the acquisition of paranasal CT scans. Specimens were obtained from the lateral nasal walls, and the ethmoid and maxillary sinuses of the animals for histopathological examination. Histopathological and CT findings were compared. Various degrees of epithelial disorganization, foci of ruptured epithelial cells, and inflammatory cell infiltration in the lamina propria were seen in the histopathological examinations of the five study rabbits, and mucosal thickening and soft tissue density were noted in their CTs. There was no correlation between the histopathological and CT findings. It was shown that CT did not reflect the acute changes in the sinus mucosa. Patients with chronic sinusitis must be evaluated for a chronic process. Computerized tomographic scans should not be obtained in acute sinusitis cases. In this way, both unnecessary radiation exposure and economic waste can be avoided.

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Section: Discussionmentioning

confidence: 91%

Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis

Özcan¹,

Özcan²,

Selçuk³

et al. 2011

Indian J Otolaryngol Head Neck Surg

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“…Clinical as well as experimental studies indicate that nasal polyp formation and growth are activated and perpetuated by an integrated process of mucosal epithelium and matrix and inflammatory cells, which in turn may be initiated by both infectious and noninfectious inflammations (23). Experimental models in which multiple epithelial disruptions with proliferating granulation tissue have been initiated by bacterial infection with Streptococcus pneumoniae, Staphylococcus aureus, Bacteroides fragilis (all common pathogens in sinusitis), or Pseudomonas aeruginosa (24) have been described previously. It appears that the cellular events of polyp formation are the results of an inflammatory reaction not directly related to the presence of a given microbial species but to the potential of a microorganism to induce trauma or epithelial desquamation.…”

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confidence: 96%

Antifungal Immune Reactivity in Nasal Polyposis

et al. 2004

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As a fungal etiology has been proposed to underlie severe nasal polyposis, the present study was undertaken to assess local antifungal immune reactivity in nasal polyposis. For this purpose, microbial colonization, along with the pattern of T helper 1 (Th1)/Th2 cytokine production and Toll-like receptor (TLR) expression, was evaluated in patients with nasal symptoms and with and without polyposis and in healthy subjects. The results show that Th2 reactivity was a common finding for patients with nasal polyposis regardless of the presence of microbes. The production of interleukin-10 was elevated in patients with bacterial and, particularly, fungal colonization, while both TLR2 expression and TLR4 expression were locally impaired in microbe-colonized patients. Eosinophils and neutrophils, highly recruited in nasal polyposis, were found to exert potent antifungal effector activities toward conidia and hyphae of the fungus and to be positively regulated by TLR2 or TLR4 stimulation. Therefore, a local imbalance between activating and deactivating signals to effector cells may likely contribute to fungal pathogenicity and the expression of local immune reactivity in nasal polyposis.

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“…According to NORLANDER et al [29], the polyp formation appears to be the result of a continuous inflammatory reaction. During inflammatory processes, neutrophil elastase is actively secreted, and this molecule is, to this day, the only molecule thought to be capable of modulating the expression of ALP [30].…”

Section: Discussionmentioning

confidence: 99%

Identification of antileucoprotease in remodelled human adult nasal surface epithelium

Marchand

Tournier²,

Chevillard³

et al. 1995

Eur Respir J

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Antileucoprotease (ALP) is generally considered as a specific marker for glandular serous cells, and plays a major role in the defence of the respiratory tract against proteolytic damage. Nevertheless, several studies have identified ALP in bronchial and bronchiolar surface epithelial cells, and also an increased number of ALP-containing cells in bronchiolar tissue during the development of pulmonary diseases. In order to define more clearly whether the surface epithelium might be involved in the defence of the respiratory mucosa, we have investigated the expression of ALP by cells of the nasal surface epithelium.Indirect immunocytochemistry and in situ hybridization for ALP were performed on human nasal polyp sections. The height of the surface epithelium, its morphology, and the degree of local inflammation were assessed in parallel.Surface epithelium morphology was highly heterogeneous. ALP-containing cells were identified, but only in remodelled areas of the surface epithelium (foldings, basal cell and/or mucous cell hyperplasia), with no association to the degree of inflammation.These results demonstrate that the surface epithelial cells of the human adult nasal mucosa can express ALP in remodelled surface epithelium, and may be actively involved in the biochemical defence of the airways. Eur Respir J., 1995, 8, 15-21.

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Formation of mucosal polyps in the nasal and maxillary sinus cavities by infection

Cited by 60 publications

References 13 publications

Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis

Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis

Antifungal Immune Reactivity in Nasal Polyposis

Identification of antileucoprotease in remodelled human adult nasal surface epithelium

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