Formation of Pimelic and Azelaic Acids, Biotin Intermediates, Derived from Oleic Acid by<i>Micrococcus</i>sp.

Ohsugi, Masahiro; Inoue, Yūta

doi:10.1080/00021369.1981.10864886

Agricultural and Biological Chemistry

1981

DOI: 10.1080/00021369.1981.10864886

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Formation of Pimelic and Azelaic Acids, Biotin Intermediates, Derived from Oleic Acid byMicrococcussp.

Masahiro Ohsugi¹,

Yūta Inoue²

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Cited by 3 publications

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Biodegradation of Picolinic Acid by a Newly Isolated Bacterium Alcaligenes faecalis Strain JQ135

Qiu

Zhang

et al. 2017

Curr Microbiol

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We isolated a bacterial strain JQ135 from municipal wastewater, which was capable of efficiently degrading picolinic acid (PA). Based on the physico-biochemical characteristics and 16S rDNA analysis, strain JQ135 was identified as Alcaligenes faecalis. In addition, strain JQ135 produced an orange pigment when cultured in the Luria-Bertani medium, which is different from the previously reported strains of A. faecalis. During the degradation of PA by the resting strain JQ135 cells, only one intermediate, 6-hydroxypicolinic acid (6HPA), was detected by ultraviolet spectrophotometry, high-pressure liquid chromatography, and liquid chromatography-mass spectrometry. A random transposon mutagenesis library of strain JQ135 was constructed. One mutant, Mut-G31, could convert PA into 6HPA without further degradation. The disrupted gene (orf2) was amplified from Mut-G31, and its product showed 32% identity to the 3-deoxy-D-manno-octulosonic acid kinase (KdkA) from Haemophilus influenzae. Results from complementation analysis confirmed that GTG was the initiation codon of the kdkA-like orf2, and that it was essential for PA biodegradation by strain JQ135. This study provides the first genetic evidence for the bacterial degradation of PA.

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Biodegradation of Picolinic Acid by a Newly Isolated Bacterium Alcaligenes faecalis Strain JQ135

Qiu

Zhang

et al. 2017

Curr Microbiol

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Advances in microbial production of medium-chain dicarboxylic acids for nylon materials

Huang

Sui

et al. 2020

React. Chem. Eng.

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Genetic analysis and characterization of a Caulobacter crescentus mutant defective in membrane biogenesis

Hodgson¹,

Shaw²,

Letts³

et al. 1984

J Bacteriol

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A mutant of Caulobacter crescentus has been isolated which has an auxotrophic requirement for unsaturated fatty acids or biotin for growth on medium containing glucose as the carbon source. This mutant exhibits a pleiotropic phenotype which includes (i) the auxotrophic requirement, (ii) cell death in cultures attempting to grow on glucose in the absence of fatty acids or biotin, and (iii) a major change in the outer membrane protein composition before cell death. This genetic lesion did not appear to affect directly a fatty acid biosynthetic reaction because fatty acid and phospholipid syntheses were found to continue in the absence of supplement. Oleic acid repressed fatty acid biosynthesis and induced fatty acid degradation in the wild-type parent, AE5000. The mutant strain, AE6000, was altered in both of these regulatory functions. The AE6000 mutant also showed specific inhibition of the synthesis of outer membrane and flagellar proteins. Total phospholipid, DNA, RNA, and protein syntheses were unaffected. The multiple phenotypes of the AE6000 mutant were found to cosegregate and to map between hclA and lacA on the C. crescentus chromosome. The defect in this mutant appears to be associated with a regulatory function in membrane biogenesis and provides evidence for a direct coordination of membrane protein synthesis and lipid metabolism in C. crescentus.

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Formation of Pimelic and Azelaic Acids, Biotin Intermediates, Derived from Oleic Acid byMicrococcussp.

Cited by 3 publications

References 2 publications

Biodegradation of Picolinic Acid by a Newly Isolated Bacterium Alcaligenes faecalis Strain JQ135

Biodegradation of Picolinic Acid by a Newly Isolated Bacterium Alcaligenes faecalis Strain JQ135

Advances in microbial production of medium-chain dicarboxylic acids for nylon materials

Genetic analysis and characterization of a Caulobacter crescentus mutant defective in membrane biogenesis

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