Formation of plasma kinins by plasmin

Lewis, George

doi:10.1113/jphysiol.1958.sp005934

Cited by 132 publications

(56 citation statements)

References 16 publications

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“…The active kallikrein formed by either method was estimated by kinin formation. It cannot be assumed, however, that the active enzyme formed in each case is the same, since plasma appears to contain more than one kininforming enzyme (Frey, Kraut & Werle, 1950;Beraldo, 1950;Lewis, 1958;Armstrong & Mills, 1964;Vogt, 1966). The results of these experiments show that thermal injury causes a pronounced increase in the kinin-forming activity elicited by treatment with acid.…”

Section: Introductionsupporting

confidence: 52%

Effect of thermal injury on the kinin system in rabbit hind limb lymph

Lewis¹,

Wawretschek²

1971

British J Pharmacology

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Summary The kinin‐forming activity of hind limb lymph and of plasma has been examined in rabbits before and after thermal injury. Neither plasma nor lymph contained much active kallikrein activity but the enzyme was evident in samples treated with glass or with acid. There was little or no increase in the activity of enzyme activated by glass after thermal injury, but an increase in the activity of enzyme activated by acid regularly occurred. There were two increases in the activity of enzyme activated by acid—one about 2 h and the other 4–6 h after thermal injury. They corresponded to increases in vascular permeability as indicated by increases in the concentration of lymph protein. There was considerably more kininogen in the lymph and plasma than was used in the assays of kallikrein activity, showing that the increased kinin‐forming activity in lymph was not the result of the passage of kininogen from the plasma. The increase in activity in lymph was not usually accompanied by a similar increase in the plasma. However, an increase in the activity of enzyme activated by acid sometimes occurred in the plasma simply as a result of prolonged anaesthesia. It is suggested that whereas the enzyme activated by glass is a measure of prekallikrein, the acid activatable enzyme appears as a result of the dissociation of a kallikrein‐inhibitor complex. An increase in the concentration of this complex is therefore an indication of the preceding activation of kallikrein.

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Section: Introductionsupporting

confidence: 52%

Effect of thermal injury on the kinin system in rabbit hind limb lymph

Lewis¹,

Wawretschek²

1971

British J Pharmacology

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“…Pseudoglobulin was prepared from dog or ox plasma by the method used by Lewis (1958). One milligram of the freeze-dried pseudoglobulin was equivalent to 0.15 ml.…”

Section: Methodsmentioning

confidence: 99%

INHIBITION OF PLASMA KININASE ACTIVITY AT SLIGHTLY ACID pH

Edery¹,

Lewis²

1962

British Journal of Pharmacology and Chemotherapy

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Kinins, like bradykinin, are rapidly inactivated in blood and interstitial fluid by an enzyme called kininase. The action of this enzyme was found to be inhibited at slightly acid pH although the formation of kinins proceeded normally. Thus a slightly acid pH which is known to occur in inflamed and damaged tissue is a suitable environment to allow accumulation of kinins which are thought to be the mediators of the inflammatory response.

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“…This TABLE 2 shows clearly that within the limits of experimental error the sensitivity of these preparations to CT varies nearly in parallel with that of plasma kinin reported by LEWIS (1958), whereas that to SP shows large discrepancies.…”

Section: IIImentioning

confidence: 57%