2009
DOI: 10.3363/prb.23.57
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Formation of Poly-L-Arginine - Hydroxyapatite Nanoparticle Complexes and Interactions Between Complexes and Lipidbilayer Membranes.

Abstract: A certain molecule permeable to a phospholipid bilayer membranes (cell or endosormal membrane) is a useful carrier (i.e. vector) for drugs (especially polymeric drugs). We prepared two types of the hydroxyapatite nanoparticlepoly-L-arginine complexes in a different solvent, which were used as the probes for the study on the translocationability through the negatively charged phospholipid bilayer membranes by means of a confocal laser scanning microscope (CLSM). CLSM observation and secondary structure of poly-… Show more

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Cited by 4 publications
(7 citation statements)
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“…The reduction in the size of the HAp-poly(Lys) complex during the translocation process results from the breaking down of the interparticle bridges as well as from related secondary structure changes in the poly(Lys) moieties (FIGURE 1). The translocation process of the HAp-poly(Lys) complex is similar to that of the HAp-poly-L-arginine complex 23,24 .…”
Section: Membrane Translocationmentioning
confidence: 54%
See 1 more Smart Citation
“…The reduction in the size of the HAp-poly(Lys) complex during the translocation process results from the breaking down of the interparticle bridges as well as from related secondary structure changes in the poly(Lys) moieties (FIGURE 1). The translocation process of the HAp-poly(Lys) complex is similar to that of the HAp-poly-L-arginine complex 23,24 .…”
Section: Membrane Translocationmentioning
confidence: 54%
“…We have reported elsewhere that cationic polymers (L-lysine, L-tyrosine copolymer, poly-L-lysine (poly(Lys)), poly-L-arginine, and polyethyrlenimine) and hydroxyapatite nanoparticle (HAp)-poly-L-arginine complexes can translocate across lipid bilayer membranes [20][21][22][23][24] .…”
Section: Introductionmentioning
confidence: 99%
“…shown in the previous paper 31 that the reduction in the size of the HAp-poly(Arg) complex during the translocation process was by virtue of breaking down of the interparticle bridges.…”
Section: Resultsmentioning
confidence: 99%
“…The bands of NH 2 and amide I associated with arginine were observed at $1448 and $1644 cm À1 , respectively. 26,32,33,39,40 The bands corresponding to -CH of glucose and C-O-C stretching bands of PEG were observed at $2943 cm À1 and $1100 cm À1 respectively (Fig. 1c).…”
Section: Synthesis and Characterizationmentioning
confidence: 95%
“…24,25,28 Increased B.E of DNA with various NPs such as HAp, chitosan and gold has been reported aer functionalization with amino acids/PEG/polyethylenimine molecules. 39,40,[46][47][48] Dynamic light scattering Dynamic light scattering was carried out to study the hydrodynamic radius and aggregation of M-HAp NPs and M-HAp NP-pDNA complexes in various media such as PBS, M.M and S.B (Table 1). M-HAp NPs and M-HAp NP-pDNA complexes dispersed in SB media showed almost 3 times larger size than those in M.M and PBS medium.…”
Section: Binding Efficiency Of M-hap Npsmentioning
confidence: 99%