Formation of reactive species via high power microwave induced DNA damage and promoted intrinsic pathway-mediated apoptosis in lung cancer cells: An in vitro investigation

Rana, Juie Nahushkumar; Mumtaz, Sohail; Han, Ihn; Choi, Eun Ha

doi:10.1016/j.fmre.2024.02.001

Cited by 11 publications

(2 citation statements)

References 54 publications

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“…A recent study also demonstrated that specific doses of HPM pulses induce apoptosis in human glioblastoma U87-MG cells [ 38 ]. The same research team studied how pulsed HPM affects NSCLC cell lines (H460 and A549) and compared them to normal lung MRC5 cells [ 39 ]. HPM primarily increases intracellular reactive species levels through a strong electric field of ∼27 kV/cm.…”

Section: Modalities In Radiotherapy Of Non-small Cell Lung Cancer (Ns...mentioning

confidence: 99%

Extracellular Vesicle- and Mitochondria-Based Targeting of Non-Small Cell Lung Cancer Response to Radiation: Challenges and Perspectives

Leonov,

Dorfman,

Pershikova

et al. 2024

Cancers

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During the cell life cycle, extracellular vesicles (EVs) transport different cargos, including organelles, proteins, RNAs, DNAs, metabolites, etc., that influence cell proliferation and apoptosis in recipient cells. EVs from metastatic cancer cells remodel the extracellular matrix and cells of the tumor microenvironment (TME), promoting tumor invasion and metastatic niche preparation. Although the process is not fully understood, evidence suggests that EVs facilitate genetic material transfer between cells. In the context of NSCLC, EVs can mediate intercellular mitochondrial (Mt) transfer, delivering mitochondria organelle (MtO), mitochondrial DNA (mtDNA), and/or mtRNA/proteinaceous cargo signatures (MtS) through different mechanisms. On the other hand, certain populations of cancer cells can hijack the MtO from TME cells mainly by using tunneling nanotubes (TNTs). This transfer aids in restoring mitochondrial function, benefiting benign cells with impaired metabolism and enabling restoration of their metabolic activity. However, the impact of transferring mitochondria versus transplanting intact mitochondrial organelles in cancer remains uncertain and the subject of debate. Some studies suggest that EV-mediated mitochondria delivery to cancer cells can impact how cancer responds to radiation. It might make the cancer more resistant or more sensitive to radiation. In our review, we aimed to point out the current controversy surrounding experimental data and to highlight new paradigm-shifting modalities in radiation therapy that could potentially overcome cancer resistance mechanisms in NSCLC.

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Section: Modalities In Radiotherapy Of Non-small Cell Lung Cancer (Ns...mentioning

confidence: 99%

Extracellular Vesicle- and Mitochondria-Based Targeting of Non-Small Cell Lung Cancer Response to Radiation: Challenges and Perspectives

Leonov,

Dorfman,

Pershikova

et al. 2024

Cancers

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“…Recently, LC treatment has made significant advances, and newer therapies such as carbon-ion radiotherapy and high-power microwaves are expected to be relatively safe treatment options for LC patients with IP complications [20,21]. However, most LC patients are already advanced at diagnosis, and pharmacotherapy remains the cornerstone of treatment.…”

Section: Interstitial Pneumonia 1introductionmentioning

confidence: 99%

Treatment Strategies for Non-Small-Cell Lung Cancer with Comorbid Respiratory Disease; Interstitial Pneumonia, Chronic Obstructive Pulmonary Disease, and Tuberculosis

Otoshi,

Ikeda,

Kaneko

et al. 2024

Cancers

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Non-small cell lung cancer (NSCLC) patients are often complicated by other respiratory diseases, including interstitial pneumonia (IP), chronic obstructive pulmonary disease (COPD), and pulmonary tuberculosis (TB), and the management of which can be problematic. NSCLC patients with IP sometimes develop fatal acute exacerbation induced by pharmacotherapy, and the establishment of a safe treatment strategy is desirable. For advanced NSCLC with IP, carboplatin plus nanoparticle albumin-bound paclitaxel is a relatively safe and effective first-line treatment option. Although the safety of immune checkpoint inhibitors (ICIs) for these populations remains controversial, ICIs have the potential to provide long-term survival. The severity of COPD is an important prognostic factor in NSCLC patients. Although COPD complications do not necessarily limit treatment options, it is important to select drugs with fewer side effects on the heart and blood vessels as well as the lungs. Active TB is complicated by 2–5% of NSCLC cases during their disease course. Since pharmacotherapy, especially ICIs, reportedly induces the development of TB, the possibility of developing TB should always be kept in mind during NSCLC treatment. To date, there is no coherent review article on NSCLC with these pulmonary complications. This review article summarizes the current evidence and discusses future prospects for treatment strategies for NSCLC patients complicated with IP, severe COPD, and TB.

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Recent Advances in Non-Thermal Plasma for Seed Germination, Plant Growth, and Secondary Metabolite Synthesis: A Promising Frontier for Sustainable Agriculture

Veerana,

Mumtaz,

Rana

et al. 2024

Plasma Chem Plasma Process

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Formation of reactive species via high power microwave induced DNA damage and promoted intrinsic pathway-mediated apoptosis in lung cancer cells: An in vitro investigation

Cited by 11 publications

References 54 publications

Extracellular Vesicle- and Mitochondria-Based Targeting of Non-Small Cell Lung Cancer Response to Radiation: Challenges and Perspectives

Extracellular Vesicle- and Mitochondria-Based Targeting of Non-Small Cell Lung Cancer Response to Radiation: Challenges and Perspectives

Treatment Strategies for Non-Small-Cell Lung Cancer with Comorbid Respiratory Disease; Interstitial Pneumonia, Chronic Obstructive Pulmonary Disease, and Tuberculosis

Recent Advances in Non-Thermal Plasma for Seed Germination, Plant Growth, and Secondary Metabolite Synthesis: A Promising Frontier for Sustainable Agriculture

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