“…However, the serious photobleaching of indocyanine green molecules under laser irradiation limits their wide applications. Although gold nanostructures are the most studied agents for the near-infrared (NIR) PTT, many anisotropic and hollow Au nanostructures lack of good photothermal stability upon irradiation of NIR laser, thereby inevitably imposing limitations in their practical therapeutic applications. ,− In comparison, the Pd-based species including Pd and Pd@Ag nanosheets et al, are new kind of promising photothermal agents because of their strong absorption in the near-infrared region, high photothermal conversion efficiency, excellent photothermal stability and biocompatibility. ,, More importantly, by changing the synthesis condition, a series of different sizes of Pd nanosheets with tunable NIR maximum absorption can be prepared. Recently, our group also has prepared ultrasmall Pd (palladium) nanosheets with the average diameter of ∼4.4 nm.…”