Formation of stress ulcer and capillary permeability of gastric mucosa in rats

Nakane, Sadao; Sakai, Takeshi

doi:10.1254/fpj.69.673

Cited by 3 publications

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“…5-HTP 100 mg/kg significantly reduced the output of PSB as well as the volume of gastric juice. Exposure to stress decreased the output of PSB and the volume of gastric juice significantly, as reported earlier (10). Pre-injection of L-dopa or 5-HTP did not signifi cantly affect the stress-induced decreases in the output of PSB.…”

Section: Resultssupporting

confidence: 87%

“…Recently, the present authors have shown that exposure of rats to stress results in a reduction of the output of injected PSB in the early stage of reserpinization while an increase is observed in the later stage (10). It is suggested that the output of PSB varies reversely to the amount of released norepinephrine which presumably determines the blood flow and/or capillary permeability of gastric mucosa.…”

Section: Resultsmentioning

confidence: 63%

“…Further studies have shown that the output of injected Pontamine Sky Blue 6BX (PSB) in the gastric juice is decreased by stress, probably due to sustained con tractions of gastric mucosal vessels resulted from liberation of monoamines and that there is a reciprocal relationship between the production of stress ulcer and the output of PSB (10).…”

mentioning

confidence: 99%

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Effects of Biogenic Monoamines and Precursors on Stress Ulcers and Secretion in Stomach

Nakane

Sakai

1974

Jpn.J.Pharmacol

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Abstract-Effectsof biogenic monoamines and their precursors on stress ulcers and secretion in stomach were investigated herein. Norepinephrine, 5-HT and their precursors prevented formation of stress ulcer at any level of endogenous monoamines in reserpine or iproniazid-treated rats. These same agents did not affect the stress induced decrease in the output of PSB but increased the pH value of gastric juice.It was reported that experimental ulcers were produced in the cat gastrointestinal tract by small doses of reserpine followed by electrical shock or hypothalamic stimulation and that the mechanism would involve a decrease in central monoamine level (1-6). It was also shown that reserpine or reserpine-like drugs caused gastric hemorrhage by a mechanism which involved release of catecholamines or serotonin (7,8).Recently, the present authors have demonstrated that formation of gastric ulcer in rats treated with a combination of reserpine and stress is due to endogenously liberated monoamines and that the decrease in gastric monoamine level prevents formation of the stress ulcer (9). Further studies have shown that the output of injected Pontamine Sky Blue 6BX (PSB) in the gastric juice is decreased by stress, probably due to sustained con tractions of gastric mucosal vessels resulted from liberation of monoamines and that there is a reciprocal relationship between the production of stress ulcer and the output of PSB (10).The present experiments were carried out to determine effects of exogenously admin istered monoamines and precursors on the production of stress ulcer at various level of endogenous monoamines as well as the effects on the output of PSB in the stomach, in order to correlate the two parameters.MATERIALS AND METHODS Stress ulcer: As described previously by Takagi and Okabe (11), male rats of Donryu strain (220-260 g) were immersed into a water bath at 23°C for 7 hr to the level of xiphoid . The animals were then sacrificed, the isolated stomach was inflated with about 10 ml water and placed in 0.5% formalin for 5 min, according to Brodie et al. (12). After washing, the stomach was incised along the greater curvature. Ulcerative changes were scored and expressed as ulcer index, according to grade and number as described by Takagi and Okabe (11).Determination of output of PSB (13) : Male Donryu strain rats (about 250 g) were

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Section: Resultssupporting

confidence: 87%

Section: Resultsmentioning

confidence: 63%

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Effects of Biogenic Monoamines and Precursors on Stress Ulcers and Secretion in Stomach

Nakane

Sakai

1974

Jpn.J.Pharmacol

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Effects of biogenic monoamines and precursors on stress ulcers and secretion in stomach

Nakane

Sakai

1974

Japanese Journal of Pharmacology

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Irregular Meal Timing Is Associated with Helicobacter pylori Infection and Gastritis

et al. 2013

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Helicobacter pylori (HP) is associated with chronic gastritis and gastric cancer, and more than half of the world's population is chronically infected. The aim of this retrospective study was to investigate whether an irregular meal pattern is associated with increased risk of gastritis and HP infection. The study involved 323 subjects, divided into three groups as follows: subjects with HP infection and gastritis, subjects with gastritis, and a control group. Subjects were interviewed on eating habits and meal timing. Multivariate logistic regression was used to compare groups. Adjusted odds ratios (OR) were derived controlling for gender, age, stress, and probiotic consumption. Subjects who deviated from their regular meals by 2 hours or more had a significantly higher incidence of HP infection with gastritis (adjusted OR = 13.3; 95% CI 5.3–33.3; P < 0.001) and gastritis (adjusted OR = 6.1; 95% CI 2.5–15.0; P < 0.001). Subjects who deviated their meals by 2 hours or more, twice or more per week, had an adjusted OR of 6.3 and 3.5 of acquiring HP infection with gastritis (95% CI 2.6–15.2; P < 0.001) and gastritis (95% CI 1.5–8.5; P < 0.001), respectively. Frequent deviation in meal timing over a prolonged period appears associated with increased risk of developing HP infection and gastritis.

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Formation of stress ulcer and capillary permeability of gastric mucosa in rats

Cited by 3 publications

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Effects of Biogenic Monoamines and Precursors on Stress Ulcers and Secretion in Stomach

Effects of Biogenic Monoamines and Precursors on Stress Ulcers and Secretion in Stomach

Effects of biogenic monoamines and precursors on stress ulcers and secretion in stomach

Irregular Meal Timing Is Associated with Helicobacter pylori Infection and Gastritis

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