Formation of strontium-substituted hydroxyapatite coatings on bulk Ti and TiN-coated substrates by plasma electrolytic oxidation

Teng, Huan-Ping; Lin, Hsin-Yi; Huang, Yu‐Hsin; Lu, Fu-Hsing

doi:10.1016/j.surfcoat.2018.02.017

Cited by 21 publications

(8 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From literature, it is known that rutile is formed at higher temperatures and at higher voltages when compared with anatase [57,58]. Teng et al [93] also reported the same trend in the MAO treatment where the relative intensity of the rutile peak increased with a higher amount of Sr. However, this phenomenon is dependent on the technique that is used to incorporate Sr. For instance, Xu et al [38] incorporated Sr in TiO 2 by plasma spraying and stated that with the increased Sr amount in the coating, the relative amount of anatase increased, showing that Sr incorporation can suppress the anatase to rutile transformation.…”

Section: Surface Characterizationmentioning

confidence: 75%

TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization

Costa

Gemini-Piperni

Alves

et al. 2021

Materials Science and Engineering: C

View full text Add to dashboard Cite

One of the main problems that remain in the implant industry is poor osseointegration due to bioinertness of implants. In order to promote bioactivity, calcium (Ca), phosphorus (P) and strontium (Sr) were incorporated into a TiO 2 porous layer produced by micro-arc oxidation. Ca and P as bioactive elements are already well reported in the literature, however, the knowledge of the effect of Sr is still limited. In the present work, the effect of various amounts of Sr was evaluated and the morphology, chemical composition and crystal structure of the oxide layer were investigated. Furthermore, in vitro studies were carried out using human osteoblast-like cells.The oxide layer formed showed a triplex structure, where higher incorporation of Sr increased Ca/P ratio, amount of rutile and promoted the formation of SrTiO 3 compound. Biological tests revealed that lower concentrations of Sr did not compromise initial cell adhesion neither viability and interestingly improved mineralization. However, higher concentration of Sr (and consequent higher amount of rutile) showed to induce collagen secretion but with compromised mineralization, possibly due to a delayed mineralization process or induced precipitation of deficient hydroxyapatite. Ca-P-TiO 2 porous layer with less concentration of Sr seems to be an ideal candidate for bone implants.

show abstract

Section: Surface Characterizationmentioning

confidence: 75%

TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization

Costa

Gemini-Piperni

Alves

et al. 2021

Materials Science and Engineering: C

View full text Add to dashboard Cite

show abstract

“…One of the available electrochemical methods is PEO (also known as micro‐arc oxidation), which generates a porous oxide layer through local plasma discharges. [ 169,170 ] Silicon and strontium can be both incorporated into the surface of titanium‐based alloys through the PEO process [ 75,171,172 ] and a gradual release of ionic products from the formed layer may lead to desired angiogenic and osteogenic effects at the affected site. Such a bioactive system should be first tested in vitro using the most relevant and accurate assays, as presented in this review.…”

Section: Discussionmentioning

confidence: 99%

Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Šalandová

Hengel

Apachitei

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper, magnesium, silicon, strontium, and zinc) with respect to their effect on the angiogenic behavior of endothelial cells (ECs) when incorporated on the surface of biomaterials. Moreover, it provides an overview of the state-of-the-art methodologies used for the in vitro assessment of the angiogenic properties of these elements. Two databases are searched using keywords containing ECs and copper, magnesium, silicon, strontium, and zinc. After applying the defined inclusion and exclusion criteria, 59 articles are retained for the final assessment. An overview of the angiogenic properties of five bioactive elements and the methods used for assessment of their in vitro angiogenic potential is presented. The findings show that silicon and strontium can effectively enhance osseointegration through the simultaneous promotion of both angiogenesis and osteogenesis. Therefore, their integration onto the surface of biomaterials can ultimately decrease the incidence of implant failure due to aseptic loosening.

show abstract

“…SBF may promote a similar Si-OH layer to form, which neutralizes charged ions in the fluid and allows for HA formation to occur [47]. Regarding titanium nitride, HA growth and cell viability are induced through the partial ionic bonding of TiN which allows for the observation of HA formation under SBF conditions [48]. Taking the additional step of converting the nitrogen to quaternary nitrogen may be responsible for the slightly larger mass and thickness of HA on the QTiN.…”

Section: Discussionmentioning

confidence: 99%

Hydroxyapatite Formation on Coated Titanium Implants Submerged in Simulated Body Fluid

et al. 2020

View full text Add to dashboard Cite

Titanium implants are commonly used in the field of dentistry for prosthetics such as crowns, bridges, and dentures. For successful therapy, an implant must bind to the surrounding bone in a process known as osseointegration. The objective for this ongoing study is to determine the potential of different implant surface coatings in providing the formation of hydroxyapatite (HA). The coatings include titanium nitride (TiN), silicon dioxide (SiO2), and quaternized titanium nitride (QTiN). The controls were a sodium hydroxide treated group, which functioned as a positive control, and an uncoated titanium group. Each coated disc was submerged in simulated body fluid (SBF), replenished every 48 h, over a period of 28 days. Each coating successfully developed a layer of HA, which was calculated through mass comparisons and observed using scanning electron microscopy (SEM) and energy dispersive analysis x-rays (EDX). Among these coatings, the quaternized titanium nitride coating seemed to have a better yield of HA. Further studies to expand the data concerning this experiment are underway.

show abstract

Formation of strontium-substituted hydroxyapatite coatings on bulk Ti and TiN-coated substrates by plasma electrolytic oxidation

Cited by 21 publications

References 46 publications

TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization

TiO2 bioactive implant surfaces doped with specific amount of Sr modulate mineralization

Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Hydroxyapatite Formation on Coated Titanium Implants Submerged in Simulated Body Fluid

Contact Info

Product

Resources

About