Formation of the Glycosidic Linkage

Williams, Spencer J.

doi:10.1016/b978-0-240-52118-3.00004-1

Cited by 4 publications

(2 citation statements)

References 405 publications

(258 reference statements)

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“…In general, this anomeric carbon atom is present in only one of the two monosaccharides that will form the final bond, for this reason, the final molecule still has a free aldehyde or ketone group and can behave as reducing sugar. The exception to this rule is sucrose since its two anomeric carbon atoms are bonded together [9,13].…”

Section: Disaccharidesmentioning

confidence: 99%

See 1 more Smart Citation

Perspective Chapter: Sugar and Its Impact on Health

Ordoñez-Araque¹,

Revelo-Vizuete²

2023

Combating Malnutrition Through Sustainable Approaches

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Consumption of foods containing free or added sugars continue to increase, causing the global prevalence of noncommunicable illnesses to rise year after year. The purpose of this chapter is to highlight the issues associated with excessive sugar consumption. The biochemical description of the major monosaccharides, disaccharides, and polysaccharides in the diet, as well as their metabolism and absorption in the organism, will be used to objectively understand how most of the carbohydrates we eat, regardless of their name, end up being used in the glycolysis pathway to produce energy. Excess sugar consumption will be converted to triglycerides and cholesterol in the body through de novo lipogenesis, increasing the prevalence of overweight and obesity, as well as other diseases. The necessity of eating fruits and vegetables with their matrix will also be emphasized, as these are linked to weight loss and obesity prevention. This does not include 100 percent natural juices, because when their matrix is broken, sugars are released and they act as sugary drinks, as well as food made with refined flours or white rice because the starch is quickly decomposed into glucose in our bodies because they are not accompanied by fiber.

show abstract

Section: Disaccharidesmentioning

confidence: 99%

“…Maltose is a disaccharide resulting from the bonding of two glucose units at carbon 1 and 4, the anomeric carbon atom is in the α-form configuration, and thus forms an α (1 ! 4) bond [13,14].…”

Section: Disaccharidesmentioning

confidence: 99%

Perspective Chapter: Sugar and Its Impact on Health

Ordoñez-Araque¹,

Revelo-Vizuete²

2023

Combating Malnutrition Through Sustainable Approaches

View full text Add to dashboard Cite

show abstract

The syntheses of polymethoxy flavonoid glycosides from apigenin and diosmetin and their cytotoxic activities on two human cancer cell lines

Nguyen

Duc

Cong

et al. 2022

Results in Chemistry

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A Glyco-chip for the Detection of Ricin by an Automated Chemiluminescence Read-out System

et al. 2013

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The plant toxin ricin is a lectin that binds to D-galactose or lactose moieties by multivalent interactions. In the present work, this avidity was used to develop a novel sandwich glyco-immunoassay using a carbohydrate microarray. For realization, 6-azidohexyl-lactose was immobilized on an alkyne silane surface by Cu(I) catalyzed click chemistry. This procedure is fast, and prevents any nonspecific binding on the microarray surface. Ricin binds via its B-chain to the lactose moieties, and is detected by the biotinylated anti-ricin A-chain. By adding a horseradish peroxidase-labeled streptavidin, a chemiluminescence signal can be generated. This method is described as a sandwich-type glyco-immunoassay. The signal on the glyco-chip can be regenerated for at least 10 measurements. The limit of detection was estimated to be 80 ng mL -1 . The assay was carried out on the automated microarray readout platform MCR 3. In this way, it took 20 min for one measurement, including regeneration of the chip surface.

show abstract

Formation of the Glycosidic Linkage

Cited by 4 publications

References 405 publications

Perspective Chapter: Sugar and Its Impact on Health

Perspective Chapter: Sugar and Its Impact on Health

The syntheses of polymethoxy flavonoid glycosides from apigenin and diosmetin and their cytotoxic activities on two human cancer cell lines

A Glyco-chip for the Detection of Ricin by an Automated Chemiluminescence Read-out System

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