Objective: To evaluate effect on comorbid disease and weight loss five years after Roux-en-Y gastric bypass (RYGB) surgery for morbid obesity in a large nationwide cohort.
Summary Background Data:The number patients having surgical procedures to treat obesity and obesity-related disease are increasing. Yet, population-based, long-term outcome studies are few. Results: BMI decreased from 42.8 ±5.5 to 31.2 ±5.5 kg/m 2 at five years, corresponding to 27.7%-reduction in total body weight. Prevalence of T2DM was reduced (15.5% to 5.9%), hypertension (29.7% to 19.5%), dyslipidemia (14.0% to 6.8%) and sleep apnea (9.6% to 2.6%). Greater weight loss was a positive, while increasing age or BMI at baseline, were negative prognostic factors for remission. The use of anti-depressants increased (24.1% to 27.5%). Laboratory status was improved, e.g. fasting glucose and glycated hemoglobin decreased from 6.1 to 5.4 mmol/mol and 41.8 to 37.7%, respectively.
Conclusions:In this nationwide study, gastric bypass resulted in large improvements in obesity-related comorbid disease and sustained weight loss over a five-year period. The increased use of anti-depressants warrants further investigation.