The research generalizes the approaches towards a country’s investment and innovation development in the modern international economic environment. It analyzes the dynamics of the investment and innovation changes in Ukraine and determines the place of the country in the world rating of poor economic positions. Some basic problems of the investment and innovation development of Ukraine’s economy in international economic conditions are highlighted. An algorithm of preparing, making and realizing investment and innovation decisions at Ukraine’s enterprises is developed considering the system impact of factors on the development of national and foreign business entities. The authors define and substantiate some strategic priorities and suggest a strategy of Ukraine’s investment and innovation development under globalization conditions