Formation of three-dimensional polymer structures through radical and ionic reactions of peroxychitosan

Budishevska, Olga; Popadyuk, Nadiya; Musyanovych, Anna; Kohut, Ananiy; Donchak, Volodymyr; Voronov, Аndriy; Voronov, Stanislav

doi:10.1016/b978-0-12-817903-1.00012-7

Cited by 8 publications

(4 citation statements)

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“…DD is defined as the ratio of the number of glucosamine groups to the total number of the N-acetylglucosamine (GlcNAc) and glucosamine (GtcN) groups. Deacetylated chitin can be called chitosan when the deacetylation degree is greater than 50% [18]. Other publications report values of 40% as well as 60% [19].…”

Section: Degree Of Deacetylationmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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Chitosan is one of the most well-known and characterized materials applied in tissue engineering. Due to its unique chemical, biological and physical properties chitosan is frequently used as the main component in a variety of biomaterials such as membranes, scaffolds, drug carriers, hydrogels and, lastly, as a component of bio-ink dedicated to medical applications. Chitosan’s chemical structure and presence of active chemical groups allow for modification for tailoring material to meet specific requirements according to intended use such as adequate endurance, mechanical properties or biodegradability time. Chitosan can be blended with natural (gelatin, hyaluronic acid, collagen, silk, alginate, agarose, starch, cellulose, carbon nanotubes, natural rubber latex, κ-carrageenan) and synthetic (PVA, PEO, PVP, PNIPPAm PCL, PLA, PLLA, PAA) polymers as well as with other promising materials such as aloe vera, silica, MMt and many more. Chitosan has several derivates: carboxymethylated, acylated, quaternary ammonium, thiolated, and grafted chitosan. Its versatility and comprehensiveness are confirming by further chitosan utilization as a leading constituent of innovative bio-inks applied for tissue engineering. This review examines all the aspects described above, as well as is focusing on a novel application of chitosan and its modifications, including the 3D bioprinting technique which shows great potential among other techniques applied to biomaterials fabrication.

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Section: Degree Of Deacetylationmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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“…Based on DD value, chitosan can be categorized as low (55–70%), middle (70–85%), high (85–95%), and ultrahigh deacetylated (95–100%). In general, deacetylation never reaches 100% [ 7 ]. DD and molecular weight strongly influence chitosan properties and thus its potential application.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific Anticancer Drug—A Comprehensive Review

Kurczewska

2023

Pharmaceutics

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Chitosan is a positively charged polysaccharide obtained through chitin deacetylation. It belongs to a group of biodegradable, bioavailable, and non-toxic materials of natural origin; thus, it is a promising matrix for creating delivery systems of different active agents. Recently, much attention has been paid to nanodelivery systems as carriers to enable better bioavailability, and thus higher efficiency of the loaded drug. The present review is focused on the progress in chitosan-based nanoparticles for the targeted delivery of antitumor drugs. The paper discusses literature reports from the last three years in which chitosan nanoparticles were applied as carriers for active substances used in antitumor therapy and potential new drugs with anticancer properties. Special attention was paid to the different treatments applied to increase the therapeutic effectiveness and minimize the side effects of a specific active substance.

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“…Chitosan is a cationic polysaccharide, biocompatible, biodegradable, bioabsorbable, non-toxic biopolymer with antibacterial, antifungal and hemostatic properties [ 2 , 8 , 9 , 15 , 17 , 18 ]. It can be obtained by the alkali N -deacetylation of chitin, the second most abundant polysaccharide in the world, which can be found in crustaceans, insects and fungi.…”

Section: Introductionmentioning

confidence: 99%

“…The amino groups (–NH 2 ) in the macromolecules’ chains are protonated (–NH 3 + ) in an acidic medium, resulting in a soluble polycation that has a high charge density. Due to the presence of the positive charge, chitosan can form complexes with other (bio)polymers that have a total negative charge (e.g., polyanionic nucleic acids) [ 4 , 18 , 19 ], as well as anionic compounds like metal anions or anionic dyes [ 9 ]. Chitosan macromolecules, containing a large number of amino and hydroxyl groups, could form complexes with transition metal ions through various mechanisms such as chelation, electrostatic attraction or ion exchange, depending on the metal ion and the pH of the solution.…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed Chitosan–Copper Complex Microspheres with Uniform Size

2021

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Chitosan-based nano- and microspheres have shown great potential in a broad range of applications, including drug delivery, bone tissue engineering, wastewater treatments, etc. The preparation of uniformly sized spheres with controlled morphology and microstructure is still a challenge. This work investigates the influence of cupric ions (Cu2+) on the size, shape, morphology and stability of electrosprayed chitosan–copper (CHT–Cu2+) complex microspheres, using chitosans with different degrees of deacetylation. The dynamic viscosity of CHT–Cu2+ solutions was measured by Höppler viscometer, while attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) was used for the identification of dried microspheres. The size, shape and morphology of microspheres were analyzed by light microscope and scanning electron microscopy (SEM), while stability of dried microspheres was evaluated in different buffer solutions. The volume ratio of wet and dry microspheres was assessed based on the estimated diameter of microspheres. The higher concentration of Cu2+ ions resulted in a decrease in viscosity of CHT–Cu2+ solutions and volume ratio of prepared microspheres. Changes in the intensities and wave numbers of absorption bands of amino and hydroxyl groups, amide I and amide II suggested that the nitrogen and oxygen atoms in chitosan are coordinating the cupric ions. Micrographs obtained by light microscope and SEM showed that all prepared samples are spherical. The increase of cupric ions concentration changed the topography of microspheres and decreased their size. These results indicated the successful electrospraying of CHT–Cu2+ microspheres with uniform size and good stability in aqueous medium.

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Formation of three-dimensional polymer structures through radical and ionic reactions of peroxychitosan

Cited by 8 publications

References 50 publications

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific Anticancer Drug—A Comprehensive Review

Electrosprayed Chitosan–Copper Complex Microspheres with Uniform Size

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