Formation of Thymine from Thymine Glycol by Gamma-irradiation in an Aqueous System

To elucidate the mechanism of the reverse reaction from thymine glycol to thymine in aqueous solution by y-irradiation, the effects of oxygen, pH and various scavengers were studied . These results indicate that the reaction is due principally to hydrated electrons . This was also demonstrated by the reaction of thymine glycol with chemically-produced electrons . The rate constant of the reaction with hydrated electrons was estimated by the competition method . E .s .r . studies in ethylene glycol glass suggested the presence of the anion intermediate . A reaction mechanism involving disproportionate processes in thymine formation is proposed .

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Sensitization of Thymine and Uracil to Ionizing Radiation byp-nitroacetophenone

Varghese

1975

International Journal of Radiation Biology and Related Studies

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p-Nitroacetophenone (PNAP) alters the radiation chemistry of thymine and uracil in de-aerated aqueous solution. In the case of thymine, it increases the yield of radiolysis products by a factor of almost two, and cis glycol of thymine is the major product. With uracil, the yield of the dimeric product, which is the major radiolysis product in de-aerated aqueous solution, is considerably reduced and the yield of cis glycol is increased. When the irradiation is carried out in N2O-saturated solution, PNAP enhances the yeild of glycol by a factor of two. The effects of cupric sulphate on the radiation chemistry of uracil are analogous to those of PNAP. A mechanism, involving a reaction between PNAP and the hydroxyl radical adduct of the pyrimidine proceeding through a one-step process, is postulated for the enhanced formation of glycol.

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Formation of Thymine from Thymine Glycol by Gamma-irradiation in an Aqueous System

Cited by 4 publications

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ChemInform Abstract: BLDG. VON THYMIN AUS THYMINGLYKOL DURCH GAMMA‐BESTRAHLUNG IM WAESSRIGEN SYST.

ChemInform Abstract: BLDG. VON THYMIN AUS THYMINGLYKOL DURCH GAMMA‐BESTRAHLUNG IM WAESSRIGEN SYST.

On the Mechanism of Thymine Formation from Thymine Glycol by γ-irradiation in Aqueous System

Sensitization of Thymine and Uracil to Ionizing Radiation byp-nitroacetophenone

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