Formation of Water-Channel by Propylene Glycol into Polymer for Porous Materials

Hong, Sun Hwa; Cho, Younghyun; Kang, Sang Wook

doi:10.3390/membranes11110881

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…Water pressure could induce the surface adhesion between AC/Gly chains and PP chains, and it was presumed to cause the crosslinking effects be tween the two polymer films. These phenomena were consistent with previous studies [33]. Polyethylene, a lithium-ion battery separator material that is currently commercially available, shows the shut-down at 130 °C and completely molten at 150 °C.…”

Section: Tga Datasupporting

confidence: 92%

Formation of Nanochannels Using Polypropylene and Acetylcellulose for Stable Separators

2022

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In this study, a polymer separator with enhanced thermal stability is prepared to solve the problem of thermal durability of lithium-ion battery separators. This separator is manufactured by coating a solution of acetyl cellulose and glycerin on polypropylene. The added glycerin reacts with the acetyl cellulose chains, helping the chains become flexible, and promotes the formation of many pores in the acetyl cellulose. To improve the thermal stability of the separator, a mixed solution of acetyl cellulose and glycerin was coated twice on the PP membrane film. Water pressure is applied using a water treatment equipment to partially connect the pores of a small size in each layer and for the interaction between the PP and acetyl cellulose. SEM is used to observe the shape, size, and quantity of pores. TGA and FT-IR are used to observe the interactions. Average water flux data of the separators is 1.42 LMH and the decomposition temperature increases by about 60 °C compared to the neat acetyl cellulose. It is confirmed that there is an interaction with PP between the functional groups of acetyl cellulose.

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Section: Tga Datasupporting

confidence: 92%

Formation of Nanochannels Using Polypropylene and Acetylcellulose for Stable Separators

2022

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“…The lower hydrophilicity of propylene glycol leads to greater flexibility of the film. 44 Camphor is a promising natural penetration enhancer because according to a study by Feng Xie et al, it exhibits a safer and more effective increase in penetration, improving the transdermal permeation of medications with various lipophilicities. 45 The accurate and consistent delivery of a specific volume with each actuation of a spray is a critical parameter that directly influences dosing precision within the application context.…”

Section: Discussionmentioning

confidence: 99%

Fabrication and in vitro characterization of curcumin film-forming topical spray: An integrated approach for enhanced patient comfort and efficacy

Shetty,

Dubey,

Chrystle

et al. 2024

F1000Res

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Background Curcumin, known for its anti-inflammatory properties, was selected for the developing consumer friendly film forming spray that offers precise delivery of curcumin and and improves patient adherence. Methods An optimized film-forming solution was prepared by dissolving curcumin (1%), Eudragit RLPO (5%), propylene glycol (1%), and camphor (0.5%) in ethanol: acetone (20:80) as the solvent. The solution was filled in a spray container which contained 70% solutions and 30% petroleum gas. In-vitro characterization was performed. Results Potential anti-inflammatory phytoconstituents were extracted from the PubChem database and prepared as ligands, along with receptor molecules (nsp10-nsp16), for molecular docking using Autodock Vina. The docking study showed the lowest binding energy of -8.2 kcal/mol indicates better binding affinities. The optimized formulation consisted of ethanol:acetone (20:80) as the solvent, Eudragit RLPO (5%) as the polymer, propylene glycol (1%) as the plasticizer, and camphor oil (0.5%) as the penetration enhancer. The optimized formulation exhibited pH of 5.8 ± 0.01, low viscosity, low film formation time (19.54 ± 0.78 sec), high drug content (8.243 ± 0.43 mg/mL), and extended ex vivo drug permeation (85.08 ± 0.09%) for nine hours. Consequently, the formulation was incorporated into a container using 30% liquefied petroleum gas, delivering 0.293 ± 0.08 mL per actuation, containing 1.53 ± 0.07 mg of the drug. The film-forming spray exhibited higher cumulative drug permeation (83.94 ± 0.34%) than the marketed cream formulation and pure drug solution after 9 h, with an enhancement ratio of 14. Notably, the film-forming spray exhibited no skin irritation and remained stable for over three months. Conclusions The developed curcumin film-forming system is promising as a carrier for wound management because of its convenient administration and transport attributes. Further in vivo studies are required to validate its efficacy in wound management.

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“…For the PVA hydrogels containing PG or VG, the evaporation of oil partially overlapped with the decomposition of PVA, forming a major weight loss between 100 and 375 °C. Among them, the PVA-PG recorded two distinct stages corresponding to the evaporation of PG starting around 120 °C (Hong et al, 2021) and the decomposition of PVA in the second stage starting at about 225 °C. For the PVA-VG, the evaporation of VG occurred between 120 °C and 300 °C (Almazrouei et al, 2019) and partially overlapped with PVA decomposition that ended around 375 °C.…”

Section: Thermogravimetric Analysis (Tga)mentioning

confidence: 99%

Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts

Cui,

Zhang,

Rodrigue

et al. 2024

Front. Drug Deliv.

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This study aimed to design a THC-rich hydrogel to deliver cannabis derivatives topically. We developed hydrogels using polyvinyl alcohol (PVA) mixed with propylene glycol (PG), vegetable glycerin (VG), or both to facilitate the dissolution of delta-9-tetrahydrocannabinol (THC). The hydrogels showed a brown color, confirming the presence of the cannabinoid. They exhibit a porous structure and better mechanical properties than PVA alone. Indeed, the hydrogel containing PG, VG, or both showed elastic deformation behaviors with lower water content. FTIR analysis demonstrated the presence of THC with two specific peaks at 1,575 and 1,619 cm−1, confirming the presence of THC in the hydrogels. Human dermal fibroblast cultures onto the surface of all hydrogels confirmed the safety of the THC-rich hydrogel as the cell adhesion was comparable to the control (no THC). Furthermore, cells adhering to the hydrogels could proliferate, showing increased cell viability at 48 and 72 h, with a higher proliferation obtained with the THC-rich PVA-PG-VG hydrogels. Such cell behavior could be due to the release of the THC in the culture medium, as demonstrated by ultra-high performance liquid chromatography (UPLC), showing the presence of THC in the culture medium, ranging from 203 to 290 μg after 24 h of incubation of the hydrogels containing PG and VG or both. In comparison, the released THC from the PVA hydrogel was higher, reaching 852 μg. It is interesting to note that the THC release at 24, 48, and 72 h was slower with the hydrogels containing PG, VG, and both, compared to PVA alone. Overall, the present study has designed safe THC-rich PVA-PG-VG hydrogels as a functional delivery system for the topical use of cannabinoids to control tissue diseases, such as inflammation.

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Formation of Water-Channel by Propylene Glycol into Polymer for Porous Materials

Cited by 9 publications

References 30 publications

Formation of Nanochannels Using Polypropylene and Acetylcellulose for Stable Separators

Formation of Nanochannels Using Polypropylene and Acetylcellulose for Stable Separators

Fabrication and in vitro characterization of curcumin film-forming topical spray: An integrated approach for enhanced patient comfort and efficacy

Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts

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