Formation process of extension knee joint contracture following external immobilization in rats

Abstract

The irrational and prolonged use of antibiotics in orthopaedic infections poses a major threat to the development of antimicrobial resistance. To combat antimicrobial resistance, researchers have implemented various novel and innovative modalities to curb infections. Nanotechnology involves doping ions/metals onto the scaffolds to reach the target site to eradicate the infective foci. In this connotation, we reviewed silver nanoparticle technology in terms of mechanism of action, clinical applications, toxicity, and regulatory guidelines to treat orthopaedic infections.

Transcriptome and Metabolome Profiling Provide New Insights into Disuse Muscle Atrophy in Chicken: The Potential Role of Fast-Twitch Muscle Fibers

“…Disuse atrophy of muscles is common in daily life and can occur due to factors such as immobilization caused by fractures [ 18 ], bed rest [ 19 ], and even in a weightless environment [ 20 ]. Molecular-level muscle atrophy can be observed within 8 days [ 21 ]. Chickens are considered an ideal animal model for studying skeletal muscle development, as their developmental anatomy is similar to that of mammals, including humans [ 22 ].…”