This article aimed to study the global consensus problem of high-order multi-agent systems with a saturation constraint and communication delay. Among them, all agents are described by discrete-time systems. Firstly, in order to compensate for the communication delay, a networked predictive control method is adopted and a predictive-based control protocol is designed. Secondly, for the neutrally stable agent model, leaderless and leader-following situations are considered and it is proven that, under a fixed communication topology, adopting the prediction-based control protocol makes the multi-agent systems with saturation constraint and communication delay achieve a global consensus. Finally, the results are illustrated via numerical simulation.