Forme initiale et évolution de la glomérulonéphrite extramembraneuse lupique pure

Systematic Review and Meta-Analysis of Immunosuppressant Therapy Clinical Trials in Membranous Lupus Nephritis

“…Twenty-four articles were identified that provided remission data on patients with MLN adequate for meta-analysis, which were used to extrapolate 34 groups of patients (Table 1). 3–27 Included studies ranged from retrospective chart reviews to a randomized controlled trial evaluating pharmacological therapy in patients with class V MLN (Table 2). 3–27 Eight articles were excluded owing to inaccessibility; reasonable effort was made to obtain each of these articles.…”

“…The SOIT group included data from several articles where less severely diseased patients were treated with SOIT compared to NSIT. 12,20 This is evident by the decreased baseline proteinuria for SOIT compared with NSIT (4.1 vs 5.4 g/d). In addition, the SOIT group had an average follow-up for remission of 63.4 months, which is significantly longer than that of the NSIT group, which was 19.2 months.…”

“…Characteristics regarding study design for all trials analyzed can be found in Table 1. 5–27 If available, the following properties of the pure class V MLN population were recorded: number of patients, remission status, immunosuppressant therapy, sex, race, duration of SLE, duration of MLN, length of follow-up, and baseline proteinuria.…”

“…Complete and partial remission criteria and rates were established within each article and are described in Table 2. 3–27 All articles used proteinuria reduction as a criterion for remission and required a reduction in proteinuria to less than 1 g/d for complete remission. Also most articles used even lower thresholds of less than 0.5 g/d (or a protein-creatinine ratio of <0.5).…”

“…Partial remission criteria also had variability among articles but required a reduction of proteinuria of more than 50% or less than 3.5 g/d for all articles. 3–25…”