Formes neurologiques des infections à Mycoplasma pneumoniae : à propos de neuf cas pédiatriques

Roussel, P; Poulat, Anne-Lise; Romaszko, J.-P.; Labbé, Annie‐Claude; Sarret, Catherine

doi:10.1016/j.arcped.2015.04.013

Cited by 3 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PRES also resolves within a week in most cases, and a possible immune-mediated mechanism with secondary endothelial damage may be the primary pathogenic mechanism. Finally, the myositis from which this boy later suffered seems to confirm the isolated observation of Roussel et al 10 who included muscle inflammation among the main symptoms of nervous system involvement by M. pneumoniae ; however, immunological tests in this patient indicated rather Streptococcus than Mycoplasma involvement. Both corticosteroids and intravenous immunoglobulins are recommended as first-line therapeutic approach in M. pneumoniae encephalitis.…”

Section: Discussionsupporting

confidence: 86%

“…Polyradiculoneuritis and axonal neuropathy have also been described in subjects with M. pneumoniae infection who responded to intravenous immunoglobulin therapy, suggesting a causal role of the immunologic inflammatory cascade. 9,10 The complete normality of NCV formally ruled out peripheral nerve involvement in our patient. Another rare brain complication of M. pneumoniae infection is PRES, 11 which usually presents with headache, vision changes, altered mental status, and/or seizures.…”

Section: Discussionmentioning

confidence: 73%

“…Nervous system involvement is common in Mycoplasma pneumoniae infection and may present as encephalitis, Guillain–Barré syndrome, transverse myelitis, aseptic meningitis, cerebellar ataxia, basal ganglia involvement, axonal neuropathy, polyradiculoneuritis, optic neuritis, ophthalmoplegia, myositis, and posterior reversible encephalopathy syndrome (PRES) 1 2 3 4 5 6 7 8 9 10 11 ; M. pneumoniae -related encephalitis, in particular, accounts for 5 to 10% of all acute cases of childhood encephalitis in Europe. 12 Fever, altered consciousness, and personality or behavioral changes were the most common initial symptoms in a recent pediatric series 12 ; the importance of psychic involvement is confirmed by the unusual occurrence of obsessive-compulsive disorder.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mycoplasma pneumoniae-Associated Encephalitis: Favorable Aggressive Immunosuppression in a Patient

Della Giustina,

Bergonzini,

Sintini

et al. 2024

Journal of Pediatric Neurology

View full text Add to dashboard Cite

Meningoencephalitis is the most important extrapulmonary manifestation of Mycoplasma pneumoniae infection. It is complicated by seizures in at least 40% of cases, and in half of them, status epilepticus can occur during the acute phase, often leading to severe neurological sequelae. Brain imaging ranges from normal to diffuse edema, focal changes, and abnormal signals in the white matter, basal ganglia, and hippocampi. Here, we describe a boy who presented with an acute onset of transient alteration of behavior, meningeal irritation, fever, vomiting, and leg pain. Meningoencephalitis due to M. pneumoniae infection was confirmed by focal pneumonia, positive immunological tests, and increased protein content in cerebrospinal fluid. Magnetic resonance imaging of the brain showed bilateral focal abnormalities in the temporoinsular cortex, and electroencephalographic recordings showed slow waves in the same regions. After early infusion of acyclovir on the first day, aggressive combination therapy with oral erythromycin, and intravenous methylprednisolone and immunoglobulin was promptly initiated once a complete diagnosis was obtained on the second day, and the boy recovered within a few days. Two weeks later, brain imaging findings had resolved completely. The rapid clinical and neuroradiological recovery after immunosuppressive therapy suggests an immune-mediated pathogenetic mechanism. He developed immune-mediated myositis 2 years later demonstrating the instability of his immunological status.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 73%