Formic Acid Poisoning in a Tertiary Care Center in South India: A 2-Year Retrospective Analysis of Clinical Profile and Predictors of Mortality

“…Even when consumed in extremely large doses (to commit suicide) there is always missing any comparable neurological damage or blindness found as with methanol poisoning associated with terminal pathology [36]. This is a tragically common event among rubber plantation workers in India [37] who die with only the typical pathology of corrosive gut tissue erosion attributable to consumption of any concentrated acid solution [38].…”

Section: Discussionmentioning

confidence: 99%

Dietary methanol and autism

Walton¹,

Monte

2015

Medical Hypotheses

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The authors sought to establish whether maternal dietary methanol during pregnancy was a factor in the etiology of autism spectrum disorders. A seven item questionnaire was given to women who had given birth to at least one child after 1984. The subjects were solicited from a large primary care practice and several internet sites and separated into two groups - mothers who had given birth to a child with autism and those who had not. Average weekly methanol consumption was calculated based on questionnaire responses. 550 questionnaires were completed by women who gave birth to a non-autistic child. On average these women consumed 66.71mg. of methanol weekly. 161 questionnaires were completed by women who had given birth to an autistic child. The average estimated weekly methanol consumption for this group was 142.31mg. Based on the results of the Wilcoxon rank sum-test, we see a significant difference between the reported methanol consumption rates of the two groups. This study suggests that women who have given birth to an autistic child are likely to have had higher intake of dietary sources of methanol than women who have not. Further investigation of a possible link of dietary methanol to autism is clearly warranted.

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“…Mortality of patients with one or more systemic complications was considerably high (45%). Dalus et al [6] reported a 100% mortality in patients with perforation or orotracheal fistula. Hypotension, respiratory symptoms, high volume or concentration of ingested acid, hematemesis, metabolic acidosis and development of acute respiratory distress syndrome were identified as further risk factors for death.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment of accidental or suicidal ingestion of undiluted hydrochloric acid mainly consists of close clinical monitoring and symptomatic therapy with gastric lavage, treatment of acidosis, pain and hemolysis. Emergency operation is indicated upon detected or suspected perforation, resulting in high mortality rates [4, 6]. We report on a fulminant course after suicidal ingestion of undiluted hydrochloric acid with a lethal outcome.…”

Section: Introductionmentioning

confidence: 99%

Fatal Course of a Suicidal Intoxication with Hydrochloric Acid

Koschny¹,

Herceg

Stremmel³

et al. 2013

Case Rep Gastroenterol

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Suicidal ingestion of undiluted hydrochloric acid is a rare but live-threatening event. We report on the dramatic and fulminant course of a 61-year-old woman who drank 200 ml of 30-33% hydrochloric acid. On admission to our intensive care unit she was alert and oriented with stable vital signs. Gastroscopy demonstrated complete necrosis from the hypopharynx to the pylorus, which was flushed continuously via drainage catheters. At that time point perforation was not evident. Shortly thereafter she developed an acute abdomen and a tension pneumothorax which was decompressed. CT scan demonstrated esophageal and intestinal perforation with massive mediastinal necrosis. On emergency laparostomy she showed complete necrosis of the intestine and stomach. The patient died 10 h after admission from multiorgan failure. The therapeutic options are critically discussed in comparison to previously reported cases in the literature.

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Formic Acid Poisoning in a Tertiary Care Center in South India: A 2-Year Retrospective Analysis of Clinical Profile and Predictors of Mortality

Cited by 16 publications

References 34 publications

A Study on Late Complications of Formic Acid Poisoning with Special Reference to Upper Gastrointestinal Tract, Kidney and Eye

A Study on Late Complications of Formic Acid Poisoning with Special Reference to Upper Gastrointestinal Tract, Kidney and Eye

Dietary methanol and autism

Fatal Course of a Suicidal Intoxication with Hydrochloric Acid

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