Forming of Polymer Nanofibers by a Pressurised Gyration Process

Muthusubramanian, Shanmugam; Edirisinghe, Mohan

doi:10.1002/marc.201300339

Cited by 201 publications

(314 citation statements)

References 28 publications

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“…Fabrication of Fibers. The fibers were fabricated using a previously reported 49 in-house built experimental setup, using the principle of infusion gyration ( Figure 1; also see Supporting Information Video S1). The device consists of a hollow aluminum rotary vessel, 25 mm in height and 60 mm in diameter, and contains 20 small round orifices.…”

Section: Methodsmentioning

confidence: 99%

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Perera

Zhang

Homer‐Vanniasinkam

et al. 2018

ACS Appl. Mater. Interfaces

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An efficient method is reported, for the fabrication of composite microfibers that can be magnetically actuated and are biocompatible, targeting controlled drug release. Aqueous solutions of polyvinyl alcohol, incorporated with citric acid-coated Fe 3 O 4 magnetic nanoparticles (MNPs), are subject to infusion gyration to generate 100− 300 nm diameter composite fibers, with controllable MNP loading. The fibers are stable in polar solvents, such as ethanol, and do not show any leaching of MNPs for over 4 weeks. Using acetaminophen as an example, we demonstrate that this material is effective in immobilization and triggered release of drugs, which is achieved by a moving external magnetic field. The remote actuation ability, coupled with biocompatibility and lightweight property, renders enormous potential for these fibers to be used as a smart drug release agent.

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Section: Methodsmentioning

confidence: 99%

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Perera

Zhang

Homer‐Vanniasinkam

et al. 2018

ACS Appl. Mater. Interfaces

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“…The viscosity of solution can vary during gyration due to a temperature gradient occurring through the polymer jets during solvent evaporation, and this could also be facilitated by increasing rotation speed [14]. Mahalingam and Edirisinghe [14] have indicated that the time constant of shearing forces applied on polymer jets during pressurised gyration will be decreased with increasing rotation speed. In addition, the time constant of shearing forces governs the responses of polymer chains, i.e.…”

Section: Fibre Morphologymentioning

confidence: 99%

“…fibres, microbubbles, capsules etc [14,15]. It effectively utilizes high speed rotation to extrude several solution jets in parallel from orifices that are located on the vessel surface.…”

Section: Introductionmentioning

confidence: 99%

“…It effectively utilizes high speed rotation to extrude several solution jets in parallel from orifices that are located on the vessel surface. The dynamic fluid flow and the governing centrifugal force compete with surface tension of solution to form well aligned polymer fibres [14]. It doesn't, like electrospinning, demand additional requirements on the electrical conductivity and dielectric constant of the polymer solution, and the absence of an applied voltage at kV level reduces the possibility to form fibres with random orientations.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, we examine a range of polymer concentration and the working parameters required for forming fibres with controllable bead on string structures. This could be used in pharmaceutical applications where particle-loaded bead on string fibres could be formed in large quantity by utilizing pressurised gyration (potentially 6 kg h -1 of fibre [14]). …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Beads, beaded-fibres and fibres: Tailoring the morphology of poly(caprolactone) using pressurised gyration

Hong

Edirisinghe

Muthusubramanian

2016

Materials Science and Engineering: C

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This work focuses on forming bead on string poly(caprolactone) (PCL) by using gyration under pressure. The fibre morphology of bead on string is an interesting feature that falls between bead-free fibres and droplets, and it could be effectively controlled by the rheological properties of spinning dopes and the major processing parameters of the pressurised gyration system which are working pressure and rotating speed. Bead products were not always spherical in shape and tender to be more elliptical, therefore both their width and length were measured. The average bead width and length produced spanned a range 145 -660µm and 140 -1060µm, respectively. The average distance between two adjacent beads (i.e. inter-bead distance) and the bead size (width and length) are shown to be a function of processing parameters and polymer concentration. An interesting morphology i.e. beads with short fibre was observed when using a high polymer concentration. Bead on string structure agglomeration was promoted by a low polymer concentration. Formation of droplets or agglomerated bead on string is promoted below 5wt% polymer concentration, and beads with short fibre were present in the microstructure beyond a polymer concentration of 20 wt%.

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High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications

Ismail,

Wu,

Khodamoradi

et al. 2024

Adv Eng Mater

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Nanofiber production techniques have become increasingly important due to their wide range of applications. However, the complex design of the setup and difficulty in scaling up to high production rate have limited the industrial applicability of some of the conventional fiber generation techniques such as electrospinning. Herein, the touch spinning method is scaled up for nanofiber production using a simple rotating drawing setup with polymers that are relevant for biomedical applications such as polyethylene oxide and gelatin. The process is amenable to use of benign solvent such as water and production of a wide variety of submicron‐scale gelatin‐based nanofibers at a high throughput (≈2.45 g hr−1 with the single channel flow), which is an order of magnitude higher than those produced by other fiber generation methods is shown. The parametric study indicates that the fiber production process can be tuned at a desired rate without sacrificing the fiber quality by simply altering the number of drawing rods, the size of the rotating disk, and the number of solution flow supply channels. The utility of this technique for different biomedical applications such as cell culture and air filtration applications is also demonstrated.

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Forming of Polymer Nanofibers by a Pressurised Gyration Process

Cited by 201 publications

References 28 publications

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Polymer–Magnetic Composite Fibers for Remote-Controlled Drug Release

Beads, beaded-fibres and fibres: Tailoring the morphology of poly(caprolactone) using pressurised gyration

High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications

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