Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma

Zhang, Liang; Wu, Qian; Huang, Yuying; Zheng, Jun; Guo, Sheng; He, Li

doi:10.1016/j.biopha.2023.115799

Cited by 16 publications

(2 citation statements)

References 49 publications

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“…PHGDH (phosphoglycerate dehydrogenase) [1429], BRCA1 [1497], FOXA1 [1498], CREB1 [1499], ESR1 [1500] and STAT3 [1501] might be a prognostic biomarker and potential therapeutic target for patients with osteoporosis. BRCA1 [1502], ESR1 [1503] and STAT3 [1504] have been linked to the start of airway inflammation. STAT3 [1505] is implicated in polycythemia.…”

Section: Discussionmentioning

confidence: 99%

Identification of key genes and biological pathways in chronic obstructive pulmonary disease using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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Identification of accurate biomarkers is still particularly urgent for improving the poor survival of chronic obstructive pulmonary disease (COPD) patients. In this investigation, we aimed to identity the potential biomarkers in COPD via bioinformatics and next generation sequencing (NGS) data analysis. In this investigation, the differentially expressed genes (DEGs) in COPD were identified using NGS dataset (GSE239897) from Gene Expression Omnibus (GEO) database. Subsequently, gene ontology (GO) and pathway enrichment analysis was conducted to evaluate the underlying molecular mechanisms involved in progression of COPD. Protein-protein interaction (PPI), modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network analysis were performed to determine the hub genes, miRNAs and TFs. The receiver operating characteristic (ROC) analysis was performed to determine the diagnostic value of hub genes. A total of 956 overlapping DEGs (478 up regulated and 478 down regulated genes) were identified in the NGS dataset. DEGs were mainly associated with GO functional terms and pathways in cellular response to stimulus. response to stimulus, immune system and neutrophil degranulation. There were 10 hub genes (MYC, LMNA, VCAM1, MAPK6, DDX3X, SHMT2, PHGDH, S100A9, FKBP5 and RPS6KA2) identified by PPI, modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network analysis. In conclusion, the DEGs, relative GO terms, pathways and hub genes identified in the present investigation might aid in understanding of the molecular mechanisms underlying COPD progression and provide potential molecular targets and biomarkers for COPD.

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Section: Discussionmentioning

confidence: 99%

Identification of key genes and biological pathways in chronic obstructive pulmonary disease using bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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“…Additionally, heightened PTGS2 expression in the smooth muscle of the distended colon of constipated rats is associated with improved smooth muscle function and increased fecal excretion upon PTGS2 inhibition [44]. In a study involving asthmatic mice exposed to house dust mite (HDM), Formononetin was found to potentially mitigate airway in ammation through the facilitation of epithelial barrier restoration and inhibition ESR1/NLRP3/Caspase-1 signaling pathway [45]. Furthermore, ESR1 polymorphisms have been associated with heightened airway sensitivity and diminished lung capacity, particularly among female asthma patients[46].…”

Section: Potential Key Targetsmentioning

confidence: 99%

A Joint Action Mechanism of “Trichosanthis Fructus-Almond” Herb Pair in the Treatment of Asthma with Functional Constipation Based on the Network Pharmacology and Molecular Docking

Dai,

Chen,

et al. 2024

Preprint

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Background：The herb combination of “Trichosanthis Fructus-Almond” herb pair is frequently employed in the treatment of respiratory ailments such as asthma and chronic obstructive pulmonary disease, and also offer some relief for constipation. However, its bioactive ingredients and mechanisms of action remain unclear. Objective: This study aimed to explore the latent mechanism of action of “Trichosanthis Fructus-Almond” herb pair in treating asthma combined with functional constipation based on network pharmacology and molecular docking. Methods: Firstly, we searched the TCMSP database to obtain the potential active ingredients of the herb pair “Trichosanthis Fructus-Amond” and their associated molecular targets. Databases such as Genecards, OMIM, TTD, and DrugBankwere enrolled to identify the targets associated with asthma and functional constipation. Then, the common targets of the “Trichosanthis Fructus-Almond” herb pair for treating asthma and functional constipation were determined by intersecting the predicted active ingredient targets with disease-related targets. Simultaneously, we visited String 11.0 to analyze the relationship within common drug-disease targets to obtain PPI network relationship. The PPI network diagram was generated using Cytoscape 3.7.2 to examine the vital targets. Furthermore, Metascape platform was utilized for GO function and KEGG pathway enrichment analysis among the shared targets. A drug component-target-pathway network diagram was lighten using Cytoscape 3.7.2. After analyzing the potential core components, molecular docking was, finally, employed to validate the core components and key targets using Autodock vina. Results: A total of 28 active components of Trichosanthis Fructus-Almond were obtained, and 27 potential targets (common targets) of “Trichosanthis Fructus-Almond” herb pair for the treatment of asthma combined with functional constipation were identified, involving 373 biological processes, 35 cellular components, 58 molecular functions, and 66 signaling pathways. primary active components were subsequently examined, like Ziziphin_qt, Stigmasterol, l-SPD, Glabridin, Estrone, Machiline, Licochalcone B, Diisooctyl succinate, Phaseol, (+)-catechin. Besides, key target proteins, such as NR3C1, PPARG, PTGS2, MAPK14, ESR1, and various pathways, including Neurodegeneration-Multiple Diseases, Chemical Carcinogenesis-Receptor Activation, Pathways of Cancer, Endocrine Resistance, NOD-like Receptors, IL-17, et, al. were uncovered. There is strong binding activity in molecular docking among key targets and potential core components. Conclusions: The current research showed that “Trichosanthis Fructus-Almond” herb pairhas various components, targets, and pathways for treating functional constipation in asthma, which may insight the further studies on its mechanism of action. This could be a crucial mechanism for managing respiratory and gastrointestinal conditions.

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DMRT3-mediated lncRNA OIP5-AS1 promotes the pyroptosis of bronchial epithelial cells by binding with EIF4A3 to enhance YAP mRNA stability

Liu,

Zheng,

Wei

et al. 2024

Immunol Res

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Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma

Cited by 16 publications

References 49 publications

Identification of key genes and biological pathways in chronic obstructive pulmonary disease using bioinformatics and next generation sequencing data analysis

Identification of key genes and biological pathways in chronic obstructive pulmonary disease using bioinformatics and next generation sequencing data analysis

A Joint Action Mechanism of “Trichosanthis Fructus-Almond” Herb Pair in the Treatment of Asthma with Functional Constipation Based on the Network Pharmacology and Molecular Docking

DMRT3-mediated lncRNA OIP5-AS1 promotes the pyroptosis of bronchial epithelial cells by binding with EIF4A3 to enhance YAP mRNA stability

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