Formononetin Inhibits Microglial Inflammatory Response and Contributes to Spinal Cord Injury Repair by Targeting the EGFR/MAPK Pathway

Fu, Haiping; Li, Mingdong; Huan, Yanqiang; Wang, Xiaolei; Tao, Mingkai; Jiang, Tianqi; Xie, Hongbin; Wujisiguleng,; Gegentana,; He, Yongxiong

doi:10.1080/08820139.2023.2183135

Cited by 6 publications

(2 citation statements)

References 51 publications

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“…Additionally, with the injection of formononetin in mice, EGFR/p38 MAPK phosphorylation was inhibited, and formononetin showed benefits in improving motor function, repairing tissue damage and inhibiting microglial inflammatory responses. 94 Pathological changes can lead to persistent inflammation in the injured area or even induce systemic inflammation in severe cases. The primary cause of this is the alteration of inflammatory factors induced by the activation of inflammatory cells, such as IL‐2, TNF‐α, anti‐GM1 ganglioside antibodies, IL‐4, and IL‐10.…”

Section: Roles Of Mapk In the Treatment Of Scimentioning

confidence: 99%

“…decreased EGFR expression using continuous infusion of C225 or AG1478 (both EGFR inhibitors) in SCI rats, leading to reduced levels of phosphorylation of ERK and p38 MAPK, activation of microglia, and astrocytes, as well as IL‐1β and TNF‐α levels, which demonstrated that inhibition of the EGFR/MAPK signaling pathway attenuated the inflammatory response of microglia and the associated secondary damage after SCI in rats. Additionally, with the injection of formononetin in mice, EGFR/p38 MAPK phosphorylation was inhibited, and formononetin showed benefits in improving motor function, repairing tissue damage and inhibiting microglial inflammatory responses 94 . Pathological changes can lead to persistent inflammation in the injured area or even induce systemic inflammation in severe cases.…”

Section: Roles Of Mapk In the Treatment Of Scimentioning

confidence: 99%

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Advances of the MAPK pathway in the treatment of spinal cord injury

Huang,

Zhang,

Shu

et al. 2024

CNS Neurosci Ther

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Spinal cord injury (SCI) represents a complex pathology within the central nervous system (CNS), leading to severe sensory and motor impairments. It activates various signaling pathways, notably the mitogen‐activated protein kinase (MAPK) pathway. Present treatment approaches primarily focus on symptomatic relief, lacking efficacy in addressing the underlying pathophysiological mechanisms. Emerging research underscores the significance of the MAPK pathway in neuronal differentiation, growth, survival, axonal regeneration, and inflammatory responses post‐SCI. Modulating this pathway post‐injury has shown promise in attenuating inflammation, minimizing apoptosis, alleviating neuropathic pain, and fostering neural regeneration. Given its pivotal role, the MAPK pathway emerges as a potential therapeutic target in SCI management. This review synthesizes current knowledge on SCI pathology, delineates the MAPK pathway's characteristics, and explores its dual roles in SCI pathology and therapeutic interventions. Furthermore, it addresses the existing challenges in MAPK research in the context of SCI, proposing solutions to overcome these hurdles. Our aim is to offer a comprehensive reference for future research on the MAPK pathway and SCI, laying the groundwork for targeted therapeutic strategies.

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Section: Roles Of Mapk In the Treatment Of Scimentioning

confidence: 99%

Section: Roles Of Mapk In the Treatment Of Scimentioning

confidence: 99%