Formula Optimization of Annona muricata Folium Ethanolic Extract of Anti Acne Gel Formulation using Factorial Design Method

Abstract

Acne is a pile of oil glands in the skin that are actively being clogged by dirt and infection because of Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. The treatment for acne can use herbal ingredients, one of which is Soursop (Annona muricata L.) leaves ethanolic extract. Annona muricata folium ethanolic extract is known to have alkaloid, flavonoid and polyphenol compounds which can inhibit the growth of P. acnes, S. epidermidis, and S. aureus. Suitable dosage forms for anti-acne preparations are gels because the gel contains much water so that it provides a cooling effect on the skin due to inflammation. The purpose of this study was to determine the impact of carbopol 940 and Propylene glycol on the physical characteristics of the gel preparation and determine the optimum formula of the gel preparation using factorial design software 22 so that the gel preparation was made in four formulas. The data obtained were then analyzed using Design-Expert� and ANOVA software with a confidence level of 95%, and the determination of the optimum formula based on the optimum superimposed contour plot area. The results of the study using a factorial design approach are known that Propylene glycol has an effect on increasing the spreadability and pH while carbopol 940 has a more significant impact on the increase in adhesion and viscosity, and the optimum area of ??the composition of carbopol 940 1.536% and propylene glycol 5% was obtained.

IRRITATION TEST OF BAWANG DAYAK (Eleutherine bulbosa(Mill.) Urb.) EXTRACT CREAM WITH HUMAN PATCH TEST METHOD

“…Cream preparations contain a relatively large amount of oil phase, especially those with the water in oil (W/O) type (Moldovan et al, 2017). In contrast to other topical preparations such as gels, which contain more water and rarely cause an itching sensation (Putri et al, 2019). However, cream preparations will provide an advantage of longer contact time between the active ingredients and the skin (Purnamawati et al, 2017).…”

OPTIMASI SEDIAAN GEL EKSTRAK RAMBUT JAGUNG (Zea mays L.) MENGGUNAKAN GELLING AGENT CARBOPOL DAN HUMEKTAN PROPILEN GLIKOL

“…Carbopol merupakan basis gel yang memberikan kekentalan pada sediaan gel dan mudah terdispersi dalam air (Saryanti and Zulfa, 2017), sedangkan propilen glikol dapat mencegah kandungan air dalam sediaan menguap sehingga kestabilan gel terjaga namun dapat membuat gel menjadi lebih cair dengan menurunkan viskositas gel (Andini et al, 2017). Propilen glikol berpengaruh terhadap peningkatan daya sebar dan pH sedangkan Carbopol lebih berpengaruh terhadap peningkatan daya lekat dan viskositas (Putri et al, 2019). Untuk itu perlu ditetapkan perbandingan carbopol dan propilen glikol dalam formula gel yang menghasilkan sediaan gel dengan sifat fisik yang optimal.…”

Pengaruh Penggunaan Peningkat Penetrasi Propilen Glikol terhadap Laju Difusi Polifenol dalam Gel Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus)

“…Jika nilai pH yang dihasilkan ekstrim dikhawatirkan akan terjadi iritasi maupun mengakibatkan munculnya sisik pada kulit. 23 Pengujian daya lekat berguna untuk mengetahui kemampuan sediaan gel dapat melekat dan menutupi permukaan pada kulit ketika digunakan agar dapat berfungsi secara optimal.…”