Ethnopharmacology is a scientific study that connects a group of people, health, and the habits of the people who use traditional medicines and formulating traditional medication. The yellow velvetleaf plant is a type of plant that lives in water. This plant can be used as a vegetable for daily consumption by the community. The yellow velvetleaf plant is a plant of the Alismataceae family. This plant is ethnopharmacological, in which there is a pharmacological effect related to treatment and health maintenance for the community because it has chemical compounds such as saponins, steroids, phenol hydroquinone, and also mineral contents: Phosphorus (P), Calcium (Ca), Potassium (K), Sodium (Na), Iron (Fe), and Zinc (Zn). This review article discusses the chemical compounds in yellow velvetleaf plants and the pharmacological effects of yellow velvetleaf plants. In this review article, it is known that yellow velvetleaf plants, used by the community as a local vegetable, have chemical compounds that can produce pharmacological effects.