Formulasi Granul Ekstrak Kulit Buah Manggis (Garcinia mangostana. L) Menggunakan Aerosil dan Avicel PH 101

Supomo, Supomo; R.W, Dayang Bella; Sa'adah, Hayatus

doi:10.25026/jtpc.v3i2.99

Cited by 3 publications

(4 citation statements)

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“…The greater the concentration of corn starch as a binder, the better the flow rate. Granule flow rate results vary because they are influenced by shape, size, surface condition, granule humidity, and the addition of pelican material Flow properties can be improved by adding lubricants to reduce friction between particles The lower the lubricant concentration, the more sticky the granules will be, resulting in the granules becoming larger in size and making it more difficult to flow (Supomo et al, 2015)., The smaller the concentration of the binder, the smaller the size, viscosity, and density, thereby increasing the cohesive force between granule or powder particles. High cohesion forces make it difficult for granules to flow freely.…”

Section: Results Of Granule Evaluationmentioning

confidence: 99%

“…Thus, all formulas can be formulated in such a way that they meet the requirements. uniformity of weights in formulas 1 and 2 are in the same subset, while in formula 3 they are in different subsets this is cause the addition binders and lubricants (glidant and antiadherent), where increasing the binder concentration will improve the size of the granules so that they flow easily, and increasing the lubricant concentration will make it easier for the granules to flow into the tablet printer (Supomo, 2015). A formula that has good flow characteristics will have a uniform ability to fill the compression space (Lestari, 2022).…”

Section: Weight Variation Testmentioning

confidence: 99%

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Preparation of Single Garlic, Red Ginger, Lemon and Apple Vinegar Combination Tablets By Wet Granulation Method

Wiendarlina,

Fatmi,

Indriati

et al. 2023

fitofarmaka JIF

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Garlic, red ginger, lemon, and apple cider vinegar are spices in Indonesia that can be useful for increasing the body's resistance and preventing degenerative diseases. Tablet preparations are preferred because they are practical, easy to use, and easy to carry anywhere. The aim of this research is to see the effect of differences in the concentration of internal and external disintegrants, binders, gliders, and lubricants in each formula. Tablets are made with the single active ingredients of garlic, red ginger, apple cider vinegar, and lemon. The wet granulation method was chosen because natural materials have poor flow properties, so by using the wet granulation method, the flow rate, compressibility, and binding capacity of the granules can be improved for the better so that they can be molded into tablet preparations. The research results showed that all tablet formulas met the tablet evaluation requirements. The concentration of external and internal disintegrants, binders, gliders, and anti-adherents does not make a difference in flow time or angle of repose but provides different water content values in formula 3.There is an influence of differences in the concentration of additional ingredients on the quality of the tablets produced. The greater the concentration, the better the weight uniformity, the harder the resulting tablet, and the longer the disintegration time. Tablet fragility on F2 is high than formula 1 and 3, but still meets tablet quality requirements.

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Section: Results Of Granule Evaluationmentioning

confidence: 99%

Section: Weight Variation Testmentioning

confidence: 99%

Preparation of Single Garlic, Red Ginger, Lemon and Apple Vinegar Combination Tablets By Wet Granulation Method

Wiendarlina,

Fatmi,

Indriati

et al. 2023

fitofarmaka JIF

View full text Add to dashboard Cite

show abstract

“…Avicel 101 is able to hold or bind 50% of the active substance or have good binding properties (Supomo, 2015). Based on this, the greater the number of Avicel PH 101 components used, the more optimal the absorption of moisture content will be and the more fulfilled the moisture content of the granules will be.…”

Section: Evaluation Of Granule Preparationsmentioning

confidence: 99%

Ethanol Extract Dry Syrup Granulation Formulation Dayak Onion Bulb (Eleutherine bulbosa (Mill.) Urb.)

Sukawaty,

Sa`adah,

Wijaya

et al. 2024

IJALSR

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Background: Dayak onion (Eleutherine bulbosa (Mill.) Urb.) is one kind of medicinal plant native to East Kalimantan that has antioxidant activity. The dosage form that can be developed is dry syrup granules which become one of the most simple dosage forms in preparation, easy to use, storage-stable and can cover the bitter taste of the drug. The goal of this study was to find the best mix of Avicel PH 101 and Na CMC to make dry syrup granules that meet the requirements for physical properties. Methods: Research was carried out experimentally using three formulas with combinations of Avicel PH 101 and Na-CMC. The ratios of Avicel PH 101 and Na-CMC were (1:0); (0.5:0.5) and (0:1). The evaluation of dry syrup granules included organoleptic observations, a moisture content test, a flowability test, a reconstitution time test, pH test, viscosity test and a hygroscopic test. Result: dry syrup granules with variation 1:0 of Avicel PH 101 and Na-CMC have the best requirements for physical properties, i.e. moisture content of 2.47%, the flow time of 0.91 seconds, an angle of repose 25.19 ° and tap index of 10.67%. Conclusion: Dry syrup granules with a ratio of Avicel PH 101 and Na CMC (1:0) are preparations that best meet the physical properties requirements, namely moisture content of 2.47%, flow time of 0.91 seconds, angle of repose 25, 19° and a fixing index of 10.67%.

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“…The preparation of granules was carried out using the wet granulation method which right choice for the development of preparations derived from plant extracts because the use of a binder in this method causes the powder particles to have high adhesion to form a regular mixture and form a cohesive network. In this granulation process, the flowability of the powder particles will be better [17]. In this manufacture, a binder in the form of PVP-K30 is used because it can produce granules that have good flow properties, minimum angle of repose, minimum % fines, and good compatibility [18].…”

Section: Introductionmentioning

confidence: 99%

Physical and Chemical Characterization of Granules from 70 % Ethanol Extract of Ganitri Leaves (Eleocarpus serratus L.) using Wet Granulation Method as An Anti-Osteoporosis

Widyowati,

Sari,

Retnowati

et al. 2024

Trends Sci

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Elaeocarpus serratus L. leaves have been used as an antiosteoporosis treatment and it contains active compounds such as quercetin, rutin, and myricetin. The pre-formulation study was done by making granules from 70 % ethanol extract of this plant through the wet granulation method. These granules were determined by physical characteristics including organoleptic, flow properties, real and incompressible specific gravity, moisture, particle size distribution, and chemical characteristics including flavonoid content. The organoleptic result showed that all formulas had a strong characteristic odor and a slightly bitter taste. Formula A had a dark brown color, while formulas B and C were whitish brown. Based on the results of the flow properties test, all formulas had good flow properties because they had gone through the granulation process. The compressibility index, Hausner ratio, and % moisture content displayed that all formulas met the requirements and had almost the same value. In the assay process, the average % w/w content of formula A was 0.68 ± 0.017 %, formula B was 0.66 ± 0.044 %, and formula C was 0.16 ± 0.006 %. The most optimum formula was formula C with whitish brown color, slightly bitter taste, and strong odor, 10.90 ± 0.000 g/s of flow rate, 25.41 ± 0.000 ° of angle, 4.36 ± 0.214 % of moisture content, 13.80 % compressibility index, 1.1601 of Hausner ratio, 1772.04 µm of particle average distribution, and 0.66 ± 0.044 % w/w of percent routine flavonoid content. HIGHLIGHTS This study aims to determine the characteristics of granules from 70 % ethanol extract of ganitri leaves (Elaeocarpus serratus), the optimal formula to make granule preparations with active ingredients of ganitri leaves, and the levels of flavonoids using the spectrophotometer method. It also determined the characteristic physics of granule preparations including flow properties, organoleptic, moisture, particle size distribution, and real and incompressible specific gravity. GRAPHICAL ABSTRACT

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Formulasi Granul Ekstrak Kulit Buah Manggis (Garcinia mangostana. L) Menggunakan Aerosil dan Avicel PH 101

Cited by 3 publications

References 0 publications

Preparation of Single Garlic, Red Ginger, Lemon and Apple Vinegar Combination Tablets By Wet Granulation Method

Preparation of Single Garlic, Red Ginger, Lemon and Apple Vinegar Combination Tablets By Wet Granulation Method

Ethanol Extract Dry Syrup Granulation Formulation Dayak Onion Bulb (Eleutherine bulbosa (Mill.) Urb.)

Physical and Chemical Characterization of Granules from 70 % Ethanol Extract of Ganitri Leaves (Eleocarpus serratus L.) using Wet Granulation Method as An Anti-Osteoporosis

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