FORMULASI MIKROPARTIKEL BERPORI DALAM POLI (D,L-Laktida) SEBAGAI SCAFFOLDDENGAN TEKNIK EMULSIFIKASI PENGUAPAN PELARUT

Abstract

Poly (D,L-lactide acid) has been used as scaffold for tissue engineering. In this study, PDLLA microparticles were made into porous microparticles. Porous microparticles were proposed to reduce burst release of protein and to prevent diffusion of released protein into non-target tissue. Formulation of porous microparticles was made by water-oil-water (W1/O/W2) emulsification-solvent evaporation using gas foamed as porogen. Variations of the amount of sodium bicarbonate, volume of citric acid solution and time for homogenization were optimized to produce optimum formulation. Evaluation for this microparticles included morphology of particles, particle size distribution and porosity. Porous microparticle produced by ratio volume of acid : dichloromethane : poly(vynil alcohol) (PVA) = 1:3:3 and the ratio of sodium bicarbonate : PDLLA = 2:3 was the optimum formulation.

Resistance of Lactobacillus fermentum InaCC B1295 Encapsulated in Microcrystalline Cellulose from Palm Leaf Waste to Acidic Conditions Across Various Temperatures and Storage Durations"

“…Inhomogeneity in the sample can occur due to brown motion in the sample. Secondly, due to a lack of operating variation [18].…”

Science Literacy Ability of High School Students in the Integration of Steam Learning with Mind Mapping Techniques on Virus Materials

“…Learners are also invited to discuss the facts used in the material with evidence in the surrounding phenomena. In fact, the research of Fitriani et al (2018) shows that there are still very few high school Biology textbooks in grade X that invite students to science literacy. Basam's research (2018) shows that the aspect of science as a way to think is in the low category, which means that improvements are needed in the application of conceptual learning, scientific attitudes and thinking process skills to be more balanced.…”