FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN KALIANDRA (Calliandra surinamensis Benth) SEBAGAI ANTIBAKTERI

Sukartiningsih, Yulita Ni Nyoman; Edy, Hosea Jaya; Siampa, Jainer Pasca

doi:10.35799/pha.8.2019.29356

Cited by 4 publications

(7 citation statements)

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“…The NaCMC properties as a base gel that can absorb water may cause an increase of the topical gel preparation. 13 This study proved that topical administration of the gel preparation of S. epidermidis extracts can accelerate wound healing time in the incision wound rats model. The effect of S. epidermidis extracts on wound healing have been reported in previous studies.…”

Section: Discussionmentioning

confidence: 58%

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Topical gel preparation from Staphylococcus epidermidis isolate extract accelerated healing on incision wound model in rats

Mochtar,

Bakhtiar,

Hamzah

et al. 2024

IJPTher

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A wound is a disorder of skin integrity caused by physical trauma or disease. Wound healing is a natural restorative response to tissue injury. It is a complex dynamic physiological process involving several overlapping phases. Although wound management has been applied, however, some time it is associated withmajor drawbak including invasiveness, antibiotic resistance, and high costs. Natural medicines are being developed for wound management to resolve the drawback. Commensal Staphylococcus epidermidis was proven to play a role in natural wound healing process. This study aimed to investigate the wound healingactivity of a topical gel preparation containing S. epidermidis isolate extract on an incision wound model in rats. The methanol extract of S. epidermidis isolate was prepared by maceration and used as an active ingredient of the topical gel using NaCMC as a gelling agent. A physical stability test was carried out by assessingorganoleptic properties, pH value, homogeneity, dispersion, and viscosity of the gel preparation. The gel preparation was then topically applied once-daily for 11 d on incision wound model of male white rats (Rattus norvegicus). The wound healing was observed daily and calculated using Morton’s formula. Nosignificant change in the physical stability parameters of the gel preparation was observed during observation on day 1, 7, and 14 (p>0.05). A significant increase in wound healing after the application of the gel preparation compared to negative control was observed (p<0.05). In contrast, no significant difference inwound healing between the gel preparation and the positive control group was observed (p>0.05). In conclusion, the topical gel preparation from S. epidermidis isolate extract accelerates healing on incision wound models in rats.

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Section: Discussionmentioning

confidence: 58%

“…The pH value of the preparation was set close to the pH of the skin between 4.5-6.5 or ideally the same, this aims to avoid irritation. 13…”

Section: Ph Measurement Testmentioning

confidence: 99%

Topical gel preparation from Staphylococcus epidermidis isolate extract accelerated healing on incision wound model in rats

Mochtar,

Bakhtiar,

Hamzah

et al. 2024

IJPTher

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show abstract

“…Hasil daya sebar sediaan gel yang baik adalah 5-7 cm atau 5,54-6,08 cm (berdasarkan standar SNI). Sediaan gel yang sulit menyebar akan mengurangi kenyamanan penggunaan dan efektivitas penggunaan sediaan gel (Sukartiningsih et al, 2019).…”

Section: Metode Penelitianunclassified

“…Data hasil uji kadar pH menunjukkan bahwa dari ketiga gel ekstrak memiliki kadar pH yang lebih tinggi dibandingkan dengan rentang kadar pH untuk kulit yakni di atas nilai kadar 6,5. Nilai pH gel yang sesuai dengan nilai pH kulit yaitu berkisar 4,5 -6,5 (Sukartiningsih et al, 2019).…”

Section: Metode Penelitianunclassified

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Pembuatan Sediaan Gel Arang Tempurung Kelapa Dan Uji Daya Hambat Terhadap Bakteri Klebsiella pneumoniae

Kamalah,

Kurniawan,

Mulyanto

et al. 2023

Borneo J Med Lab Tech

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Klebsiella pneumoniae is a gram-negative rod-shaped bacterium that is a member of the Enterobacteriaceae group of bacteria and is pathogenic and can infect humans. Currently, many K. pneumoniae bacteria are resistant to antibiotics, giving rise to new problems in the health sector that must be addressed immediately by utilizing biodiversity in the form of medicinal plants such as coconut trees, which can produce coconut shells that can be made into charcoal. The results of the phytochemical analysis show that coconut shell charcoal contains many active compounds that have been used in the cosmetic and health industries. The purpose of this study was to obtain an optimal and effective coconut shell charcoal extract gel formula for inhibiting the growth of K. pneumoniae bacteria. This study included a true experimental post-only control group with different gel concentration groups, namely 3%, 6%, and 9%. The optimal formulation of coconut shell charcoal extract gel is a gel with a concentration of 9%, and the results of the one-way ANOVA statistical analysis show that the treatment of the inhibition test on K. pneumoniae bacteria from gels with different concentrations shows that there is a mean difference in the area of the inhibition zone with a significant value of 0.033 (p<0.05). The results of the LSD post-hoc test showed that several treatment groups had significant values (p <0.05). Based on the results of the study, it can be concluded that the optimal formulation of shell charcoal extract gel is a gel with a concentration of 9%, while the most effective gel for inhibiting the growth of K. pneumoniae bacteria is a gel with a concentration of 3%.

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Antibacterial Test Of Ethanol Extract Gel Preparation Kencur Rhizome (Kaempferia Galanga) Against Staphylococcus Epidermidis

Husnul Hotimah,

Juvita Herdianty

2024

Strada J. Pharm.

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Staphylococcus epidermidis is one of the bacteria that causes acne. infections can be treated by using natural antibiotics. galangal rhizome (Kaempferia galanga L.) contains chemical compounds including flavonoids, saponins, tannins, alkaloids and terpenoids/steroids where these active compounds have an antibacterial function that can overcome acne problems on the surface of the skin. Galangal rhizome ethanol extract gel preparations were made with 3 variations of concentration (10%, 15% and 20%). The aim of this research was to determine whether the ethanol extract gel preparation of kencur rhizome (Kaempferia galanga L.) had antibacterial activity against Staphylococcus epidermidis and to determine the physical quality of the gel preparation. The method used is an experimental laboratory which is useful for determining the effect of ethanol extract of kencur rhizomes with concentrations of 10%, 15% and 20% on Staphylococcus epidermidis bacteria in gel preparations. The antibacterial test was carried out using the well diffusion method. The antibacterial test results with concentrations of 10%, 15% and 20% respectively were 13.68; 13.60 ; 14.24 mm has an influence on the inhibition zone of Staphylococcus epidermidis bacteria. The research results showed that a concentration of 20% had the highest bacterial inhibitory power.

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FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN KALIANDRA (Calliandra surinamensis Benth) SEBAGAI ANTIBAKTERI

Cited by 4 publications

References 0 publications

Topical gel preparation from Staphylococcus epidermidis isolate extract accelerated healing on incision wound model in rats

Topical gel preparation from Staphylococcus epidermidis isolate extract accelerated healing on incision wound model in rats

Pembuatan Sediaan Gel Arang Tempurung Kelapa Dan Uji Daya Hambat Terhadap Bakteri Klebsiella pneumoniae

Antibacterial Test Of Ethanol Extract Gel Preparation Kencur Rhizome (Kaempferia Galanga) Against Staphylococcus Epidermidis

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