Formulasi Sediaan Nano Herbal Tempuyung  (Sonchus arvensis L.) dalam Bentuk Self Nano-Emulsifying Drug Delivery System (SNEDDS)

Wijiyanto, Budy; Damayanti, Primadara; Sitorus, Mira Amaliasari; Listianingrum, Ratih Dyah; Dea, Arifa Caryn; Syukri, Yandi

doi:10.29208/jsfk.2016.3.1.99

Cited by 6 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nanoemulsion andaliman was formulated using the SNEDDS method [ 18 ]. The composition of the nanoandaliman product was andaliman extract, capryol-90, polyethylene glycol (PEG 400; food grade), and Tween 20.…”

Section: Methodsmentioning

confidence: 99%

Anti-Arthritic and Anti-Inflammatory Effects of Andaliman Extract and Nanoandaliman in Inflammatory Arthritic Mice

Setiadi

Karmawan

Yanti

2022

Foods

View full text Add to dashboard Cite

Inflammatory arthritis is a severe joint disease that causes long-lasting pain that reduces a patient’s quality of life. Several commercial medicines have been used to reduce the inflammation in arthritis. However, they have side effects that affect other organs and increase the infection rate in the patient. Therefore, searching for alternative medicines from natural herbs to use as a substitute for chemical drugs and reduce the side effects of drugs has become the focus of investigation. Zanthoxylum acanthopodium DC., known as andaliman, is an endemic spice that originates from Tapanuli, North Sumatera (Indonesia). Our previous study confirmed that andaliman exerts anti-inflammatory and xanthin oxidase enzymatic inhibitory activities. Unfortunately, there are no in vivo studies on the efficacy of andaliman in reducing inflammation in arthritis. This research aimed to produce an andaliman extract rich in essential oils, to formulate andaliman extract in a nanoemulsion product, and to test their anti-arthritic and anti-inflammatory effects on suppressing the gene expression of inflammatory arthritis in vivo. Several steps were used to conduct this experiment, including andaliman extraction, bioactive compound identification, nanoandaliman formulation, in vivo inflammatory arthritis mice modeling using complete Freund’s adjuvant (CFA), and gene expression quantification using quantitative PCR (qPCR). Andaliman extract and nanoandaliman effectively reduced arthritic scores in CFA-induced arthritic mice. Both treatments also demonstrated anti-inflammatory potential via blocking several arthritic inflammatory gene expressions from cartilage tissue and brain in CFA-induced mice. Nanoandaliman at low dose (25 mg/kg bw) exerted a higher suppressive effect against the gene expression of cox-2, il-ib, inos, and mmp-1 compared to that of andaliman extract. At high dose (100 mg/kg bw), andaliman extract effectively inhibited the expression of il-ib, inos, and mmp-1 genes in arthritic mice. These data suggest that nanoandaliman may be an alternative, natural anti-arthritic and anti-inflammatory candidate for the management of inflammatory arthritis.

show abstract

Section: Methodsmentioning

confidence: 99%

Anti-Arthritic and Anti-Inflammatory Effects of Andaliman Extract and Nanoandaliman in Inflammatory Arthritic Mice

Setiadi

Karmawan

Yanti

2022

Foods

View full text Add to dashboard Cite

show abstract

“…The Indonesian herbal pharmacopoeia recommends using an ethanol solvent since it is volatile, practically mixes with water in different situations, is non-toxic, and can dissolve at different degrees of polarity. Ethanol is commonly used as a solvent in the preparation of herbal extracts in Indonesia (Dewi and Kartini, 2023;Gurning and Sinaga, 2020;Johan Sukweenadhi et al, 2020;Rahmaniati M et al, 2018;Welly Ria Utami Lubis et al, 2023;Wijiyanto et al, 2016)…”

Section: Extract Preparationmentioning

confidence: 99%

PHYTOCHEMICAL SCRINING AND DETERMINATION OF SECONDARY METABOLITICAL CAPACITY OF BUTTERFLY LEAVES (Bauhinia Purpurea L) AS A GUIDE FOR WOUND HEALING IN WOMEN AFTER PREGNANCY

Tunggal,

Yuniarti,

Rusmilawaty

et al. 2024

J. of Law and Sust. Develop.

View full text Add to dashboard Cite

Objective: The objectives of the research were to break down and analyze the secondary metabolite chemical compounds identified in Butterfly Leaves (Bauhinia purpurea L) and determine the amount present in the plant. Theoretical framework: Proper perineal wound care will help the perineal wound healing process in a short time. One of the ways to treat wounds in postnatal women is to use a traditional butterfly flower herb as a means of accelerating wound healing. Proper perineal wound care will help the perineal wound healing process, so the wound can heal quickly. One way to treat perineal wounds that can be done is to use a butterfly flower plant (Bauhinia Purpurea L). Methods: This research design is experimental, testing the levels of alkaloid compounds, flavonoids, saponins, steroids, tannins in butterfly leaves (Bauhinia Purpurea L). The population and sample were all butterfly leaves. This research was conducted at a herbal medicine factory in Banjarmasin. Results and conclusions: The group of secondary metabolite compounds contained in the butterfly leaf (Bauhinia Purpurea L.): Flavoid, tannin, phenol, alkaloid, safonim and steroid). Secondary metabolic levels in butterfly leaves and flowers: Flanoids: 19.03 mg/g (1.90%), Tannins: 23.39 mg/g (2.33 %), Phenol: 37.84 mg/g (3.78 %), Alkoloids: 2.48 mg/g (2.48 %), Saponins: 11.26 mg/g (0.12 %), Steroids: 2.32 mg/g (2.32%). Proper perineal wound care will help the healing process of perineal wounds, so that the wound can heal in a short time. One way of treating perineal wounds that can be done is using butterfly flower plants (Bauhinia Purpurea L). Implications of the research: This research provides a scientific basis for understanding the chemical composition of butterfly leaves (Bauhinia purpurea L) and highlights their potential benefits in perineal wound care. The implications extend to herbal medicine practices, healthcare for postnatal women, the integration of traditional and modern medicine, and the promotion of further research and development in this field.

show abstract

“…Achieving the maximum value for desirability indicates that the goal selection for the five characterizations is correct. [9][10][11][12] The results in…”

Section: The Optimum Formula Of Snedds Fenofibratementioning

confidence: 99%

Optimization and Characterization of Fenofibrate Self-Nanoemulsifying Drug Delivery System (SNEDDS) Preparations

Sukarno,

Ilham Kuncahyo,

Endang Dyah Ikasari

2023

OAIJMR

View full text Add to dashboard Cite

Fenofibrate is a third-generation fibric acid derivative included in BCS (biopharmaceutical classification system) class II, namely high permeability, low solubility. This research aims to obtain the optimum formula for miglyol oil, cremophor RH 40 and PEG 400 according to characterization tests of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research is an experimental study by formulating fenofibrate in the form of SNEDDS, which was made in 16 formulas using the D-optimal method, which was formulated in the form of SNEDDS with the composition miglyol, cremophor RH 40 and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, size. globules, zeta potential to obtain the optimum formula, and then analyzed using the one sample T-Test. The optimization results obtained the optimum formula, namely miglyol at 4%; cremophor RH 40 is 5%, and PEG 400 at 1%. Characterization test: emulsification time was 24 seconds, Transmittance % was 98.7%, Drug loading was 181 mg, globule size was 126 nm, and zeta potential of 12.26 mV. The dissolution test of the fenofibrate capsule dissolved 57.05%, while the fenofibrate SNEDDS capsule was 64.86%. This means that the dissolution of the optimum formula for SNEDDS fenofibrate is better than pure fenofibrate.

show abstract

Formulasi Sediaan Nano Herbal Tempuyung (Sonchus arvensis L.) dalam Bentuk Self Nano-Emulsifying Drug Delivery System (SNEDDS)

Cited by 6 publications

References 3 publications

Anti-Arthritic and Anti-Inflammatory Effects of Andaliman Extract and Nanoandaliman in Inflammatory Arthritic Mice

Anti-Arthritic and Anti-Inflammatory Effects of Andaliman Extract and Nanoandaliman in Inflammatory Arthritic Mice

PHYTOCHEMICAL SCRINING AND DETERMINATION OF SECONDARY METABOLITICAL CAPACITY OF BUTTERFLY LEAVES (Bauhinia Purpurea L) AS A GUIDE FOR WOUND HEALING IN WOMEN AFTER PREGNANCY

Optimization and Characterization of Fenofibrate Self-Nanoemulsifying Drug Delivery System (SNEDDS) Preparations

Contact Info

Product

Resources

About