Formulating Drug Delivery Systems by Spray Drying

Ré, Maria Inês

doi:10.1080/07373930600611877

Cited by 178 publications

(89 citation statements)

References 95 publications

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“…Polyesters gather important requirements, such as good biocompatibility, biodegradability and easiness to process, and thus they are usually chosen for the manufacturing of such products. As a result, it is possible to control the drug release over time as the polymer fraction is gradually degraded toward the physiological environment [32,34]. There are several studies which have reported the production of a wide variety of polymeric microspheres using spray drying.…”

Section: Spray-drying Applications In the Biomedical Areamentioning

confidence: 99%

“…The fact that this technological process enables to dry heat-sensitive components, like enzymes or proteins, without compromising their biological activity makes the production of such systems possible [32,33]. As a result, within the biomedical field, spray drying is primarily used to produce dry powder aerosols and to tune active pharmaceutical compounds, making them useful and suitable for drug delivery [11,32].…”

Section: Spray-drying Applications In the Biomedical Areamentioning

confidence: 99%

“…Regarding the spray-drying approach aiming drug encapsulation and delivery systems, it usually takes advantage of a complex initial system containing the active drug substance and an aqueous/organic phase (solution, emulsion or suspension) to produce either microspheres or microcapsules [11,32].…”

Section: Spray-drying Applications In the Biomedical Areamentioning

confidence: 99%

See 2 more Smart Citations

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

124

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Spray drying is a well-known method of particle production which comprises the transformation of a fluid material into dried particles, taking advantage of a gaseous hot drying medium, with clear advantages for the fabrication of medical devices. In fact, it is quite common the production of microspheres and microcapsules designed for drug delivery systems. This review describes the different stages of the mechanism of the spray-drying process: atomization, droplet-to-particle conversion and particle collection. In particular, this work addresses the diversity of available atomizers, the drying kinetics and the importance of the configuration of the drying chamber, and the efficiency of the collection devices. The final properties of the dried products are influenced by a variety of factors, namely the spray dryer design, the feed characteristics and the processing parameters. The impact of those variables in optimizing both the spray-drying process and the synthesis of dried particles with desirable characteristics is discussed. The scalability of this manufacturing process in obtaining dried particles in submicron-to-micron scale favors a variety of applications within the food, chemical, polymeric, pharmaceutical, biotechnology and medical industries.

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Section: Spray-drying Applications In the Biomedical Areamentioning

confidence: 99%

Section: Spray-drying Applications In the Biomedical Areamentioning

confidence: 99%

See 1 more Smart Citation

Spray Drying: An Overview

Santos¹,

Maurício²,

Sencadas³

et al. 2018

Biomaterials - Physics and Chemistry - New Edition

124

View full text Add to dashboard Cite

show abstract

“…Este tipo de processo permite a formação de microesferas ou microcápsulas, dependendo da formulação inicial (RÉ, 2006). O princípio básico de funcionamento do spray dryer é a conversão um líquido (emulsão, solução, suspensão e/ou dispersão) em um material seco, particulado, por meio da atomização do fluxo de alimentação em uma câmara de secagem aquecida (RÉ, 2006).…”

Section: Nanospray Drying Como Técnica De Nanoencapsulaçãounclassified

“…O princípio básico de funcionamento do spray dryer é a conversão um líquido (emulsão, solução, suspensão e/ou dispersão) em um material seco, particulado, por meio da atomização do fluxo de alimentação em uma câmara de secagem aquecida (RÉ, 2006). Spray drying tem sido utilizado em estudos de tecnologia farmacêutica com a proposta de secagem de materiais sensíveis à temperatura, melhoria de propriedades de fluidez, preparo de grânulos "free-flowing" para produção de comprimidos, e melhoria da solubilidade de substâncias pouco solúveis em água (RÉ, 2006 O líquido a ser introduzido no Nano Spray Dryer pode conter uma solução, suspensão ou uma emulsão (BUCHI, 2009). Para a encapsulação de partículas, estas devem estar suspensas no líquido, juntamente com a substância encapsulante, um polímero, por exemplo.…”

Section: Nanospray Drying Como Técnica De Nanoencapsulaçãounclassified