2013
DOI: 10.2147/ijn.s46207
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Formulating food protein-stabilized indomethacin nanosuspensions into pellets by fluid-bed coating technology: physical characterization, redispersibility, and dissolution

Abstract: Background: Drug nanosuspensions are very promising for enhancing the dissolution and bioavailability of drugs that are poorly soluble in water. However, the poor stability of nanosuspensions, reflected in particle growth, aggregation/agglomeration, and change in crystallinity state greatly limits their applications. Solidification of nanosuspensions is an ideal strategy for addressing this problem. Hence, the present work aimed to convert drug nanosuspensions into pellets using fluid-bed coating technology. M… Show more

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Cited by 17 publications
(1 citation statement)
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“…Dried indomethacin nanosuspensions were prepared by spraying the nanosuspensions onto pellets by fluid bed coating method. Similar dissolution profiles were demonstrated between dried pellets with nanosuspension and drug nanosuspensions [24]. Pellets incorporating nanosuspension of ketoprofen for sustained release of drugs up to 24 h duration has been disclosed [82].…”
Section: Pelletssupporting
confidence: 52%
“…Dried indomethacin nanosuspensions were prepared by spraying the nanosuspensions onto pellets by fluid bed coating method. Similar dissolution profiles were demonstrated between dried pellets with nanosuspension and drug nanosuspensions [24]. Pellets incorporating nanosuspension of ketoprofen for sustained release of drugs up to 24 h duration has been disclosed [82].…”
Section: Pelletssupporting
confidence: 52%