Formulating Ternary Inclusion Complex of Sorafenib Tosylate Using β-Cyclodextrin and Hydrophilic Polymers: Physicochemical Characterization and In Vitro Assessment

Donthi, Mahipal Reddy; Munnangi, Siva Ram; Krishna, Kowthavarapu Venkata; Marathe, Sandhya Amol; Saha, Ranendra N.; Singhvi, Gautam; Dubey, Sunil Kumar

doi:10.1208/s12249-022-02406-6

Cited by 16 publications

(14 citation statements)

References 48 publications

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“…Similarly, the previous studies reported that the phase solubility curve for SOR and βCD was an A L -type, with the K c value of 68.3 M −1 and 735.8 M −1 . 24,66 However, the phase solubility curve for SOR and γCD was reported to be a B S -type, with a K c value of 172.5 M −1 . 24…”

Section: Resultsmentioning

confidence: 99%

Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: in silico and in vitro studies

Aman,

Ali,

Mahalapbutr

et al. 2023

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: in silico and in vitro studies

Aman,

Ali,

Mahalapbutr

et al. 2023

RSC Adv.

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“…5 A), wherein the authors found that the interaction between the sorafenib tosylate and β-CD is strongest among the other natural CDs with the binding affinity of -6.1 kcal/mol. The studies also revealed the stoichiometry of sorafenib tosylate and β-CD in the ratio of 1:1 [ 58 ]. However, this molecular docking technique has been confined to the application for CD complexes because molecular docking requires the target (i.e., the CD) with docking site-like proteins.…”

Section: Determination Of Stoichiometry Ratio Of Reactants (Drug and ...mentioning

confidence: 99%

“…5 A) Molecular docking studies and the structures of SFNT ( a ), β-CD ( b ), top view of SFNT/β-CD inclusion complex ( c ), bottom view of SFNT/β-CD inclusion complex ( d ), side view of SFNT/β-CD inclusion complex ( e ), and hydrogen bond (yellow dotted line) representation in SFNT/β-CD inclusion complex ( f ). Reproduced with permission from ref [ 58 ]. B) Molecular structure simulation of IPA association produced using Gauss View package.…”

Section: Determination Of Stoichiometry Ratio Of Reactants (Drug and ...mentioning

confidence: 99%

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Drug complexes: Perspective from Academic Research and Pharmaceutical Market

et al. 2023

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Despite numerous research efforts, drug delivery through the oral route remains a major challenge to formulation scientists. The oral delivery of drugs poses a significant challenge because more than 40% of new chemical entities are practically insoluble in water. Low aqueous solubility is the main problem encountered during the formulation development of new actives and for generic development. A complexation approach has been widely investigated to address this issue, which subsequently improves the bioavailability of these drugs. This review discusses the various types of complexes such as metal complex (drug-metal ion), organic molecules (drug-caffeine or drug-hydrophilic polymer), inclusion complex (drug-cyclodextrin), and pharmacosomes (drug-phospholipids) that improves the aqueous solubility, dissolution, and permeability of the drug along with the numerous case studies reported in the literature. Besides improving solubility, drug-complexation provides versatile functions like improving stability, reducing the toxicity of drugs, increasing or decreasing the dissolution rate, and enhancing bioavailability and biodistribution. Apart, various methods to predict the stoichiometric ratio of reactants and the stability of the developed complex are discussed. Graphical Abstract

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“…Various techniques have been employed to increase the solubility of active moieties. These techniques include physical and chemical modification of API along with formulation strategies, which include particle size reduction, complexation, amorphization, and nano-carrier drug delivery systems as represented in Figure 1 [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery

et al. 2023

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Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated preparation of different systems aims to deal with these limitations. The novel system prepared by the incorporation of nano-emulsion into gel improves stability and enables drug delivery for both immediate and controlled release. The focus on nano-emulgel has also increased due to its ability to achieve targeted delivery, ease of application, absence of gastrointestinal degradation or the first pass metabolism, and safety profile. This review focuses on the formulation components of nano-emulgel for topical drug delivery, pharmacokinetics and safety profiles.

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Formulating Ternary Inclusion Complex of Sorafenib Tosylate Using β-Cyclodextrin and Hydrophilic Polymers: Physicochemical Characterization and In Vitro Assessment

Cited by 16 publications

References 48 publications

Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: in silico and in vitro studies

Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: in silico and in vitro studies

Drug complexes: Perspective from Academic Research and Pharmaceutical Market

Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery

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