Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing

Gan, Jhing-Ee; Chin, Chai-Yee

doi:10.12688/f1000research.52528.1

Cited by 12 publications

(8 citation statements)

References 19 publications

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“…Previous studies showed that plant extracts rich in gallic acid and tannins can accelerate wound repair. 30,[44][45][46] Our data showed that PE can improve wound closure in vitro and in vivo, and these results are supported by other works. 34,47 Likewise, when human keratinocytes were treated with gallic acid at 10, 20, 50, 100, or 200 μM, this compound increased wound closure and cell migration.…”

Section: Discussionsupporting

confidence: 90%

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Exploring the association between a standardized extract of pequi peels (Caryocar brasiliense Cambess) and blue light as a photodynamic therapy for treating superficial wounds

Diniz,

Ferreira,

Ribeiro

et al. 2023

Photochem & Photobiology

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Natural products derived from plants can be used as photosensitizers for antimicrobial photodynamic therapy (aPDT) combining key therapeutic strategies for tissue repair while controlling microorganisms' growth. We investigated a standardized extract of pequi peels (Caryocar brasiliense Cambess) as a brownish natural photosensitizer for aPDT using blue light. Three concentrations of the pequi extract (PE; 10, 30, or 90 μg/mL) were tested solely or associated with blue laser (445 nm, 100 mW, 138 J/cm2, 6 J, 60 s). In vitro, we quantified reactive oxygen species (ROS), assessed skin keratinocytes (HaCat) viability and migration, and aPDT antimicrobial activity on Streptococcus or Staphylococcus strains. In vivo, we assessed wound closure for the most active concentration disclosed by the in vitro assay (30 μg/mL). Upon aPDT treatments, ROS were significantly increased in cell monolayers regardless of PE concentration. PE at low doses stimulates epithelial cells. Although PE stimulated cellular migration, aPDT was moderately cytotoxic to skin keratinocytes, particularly at the highest concentration. The antimicrobial activity was observed for PE at the lowest concentration (10 μg/mL) and mostly at PE 10 μg/mL and 30 μg/mL when used as aPDT photosensitizers. aPDT with PE 30 μg/mL presents antimicrobial activity without compromising the initial phases of skin repair.

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Section: Discussionsupporting

confidence: 90%

“…Bioactive natural products can optimize the wound healing process. Previous studies showed that plant extracts rich in gallic acid and tannins can accelerate wound repair 30,44–46 . Our data showed that PE can improve wound closure in vitro and in vivo, and these results are supported by other works 34,47 .…”

Section: Discussionsupporting

confidence: 88%

Exploring the association between a standardized extract of pequi peels (Caryocar brasiliense Cambess) and blue light as a photodynamic therapy for treating superficial wounds

Diniz,

Ferreira,

Ribeiro

et al. 2023

Photochem & Photobiology

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“…To decide the substance's melt point, a little quantity of the drug was put in a capillary tube that was closed at one end. It is additionally linked to the thermometer that is positioned in the middle of a heating bath in order to track the temperatures at which melting begins and stops and to gradually heat the bath [7].The equilibrium solubility method was used to calculate the solubility. Separate doses of gallicacid were injected into screw-capped beaker vials that held 5ml of the solvent [8].…”

Section: Determination Of Melting Point and Solubilitymentioning

confidence: 99%

Synergestic effect of gallic acid lipid nanoparticles to improve the physiochemical property and cellular uptake against MDA MB 231 Cancer cell line: Apoptosis, signaling pathway and cytotoxicity

2023

JPTCP

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Introduction: Gallic acid (GA), a phenolic molecule that occurs naturally, has been shown to have anti-tumor properties for a number of cancer types. The effect of GA on breast tumor cells MDA-MB-231 Triple Negative was examine in the current study. Methods: Techniques were utilised for cell cycle analysis, GSH concentration, Annexin V assay, light and fluorescence microscopy, restriction of cell growth (MTT assay), preparation, characterisation, and measurement of the mitochondrial membrane potential. Results: It was shown that the produced GANP significantly reduced the ability of MDAMB-231 cells to multiply. Moreover, this might result in glutathione depletion, an increase in ROS levels, and cytotoxic activity in MDA-MB-231 cells. Analysis using flow cytometry revealed so as to the GANP enhanced the inhabitants of sub-G1 cells. Also, the Annexin V/PI test and fluorescence labelling both established so as to the addition of GA dramatically increased the amount of apoptotic cells. Therefore, research of the oxidative damage-related sickness revealed that the amalgamation of GA greatly decrease oxidative damage in healthy cells while increasing glutathione levels and lowering lipid peroxidase levels in MDA-MB-231 cells Conclusion: These consequences propose that GA as GANP may have potential as a chemopreventive treatment for triple negative breast cancer.

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“…Despite this, gallic acid’s low solubility and susceptibility to environmental factors have limited its application in the pharmaceutical industry. The beneficial characteristics of GA provide the potential for it to be developed into a useful agent for the treatment of wounds [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid-Loaded Sodium Alginate-Based (Polyvinyl Alcohol-Co-Acrylic Acid) Hydrogel Membranes for Cutaneous Wound Healing: Synthesis and Characterization

Naeem

Zhu

et al. 2022

Molecules

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Traditional wound dressings often cannot treat wounds caused by bacterial infections or other wound types that are insensitive to these wound treatments. Therefore, a biodegradable, bioactive hydrogel wound dressing could be an effective alternative option. The purpose of this study was to develop a hydrogel membrane comprised of sodium alginate, polyvinyl alcohol, acrylic acid, and gallic acid for treating skin wounds. The newly developed membranes were analyzed using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), sol-gel fraction, porosity, mechanical strength, swelling, drug release and data modelling, polymeric network parameters, biodegradation, and antioxidation (DPPH and ABTS) and antimicrobial activity against Gram-positive and negative bacteria. The results revealed that hydrogel membranes were crosslinked successfully and had excellent thermal stability, high drug loading, greater mechanical strength, and exhibited excellent biodegradation. Additionally, the swelling ability and the porosity of the surface facilitated a controlled release of the encapsulated drug (gallic acid), with 70.34% release observed at pH 1.2, 70.10% at pH 5.5 (normal skin pH), and 86.24% at pH 7.4 (wounds pH) in 48 h. The gallic acid-loaded hydrogel membranes showed a greater area of inhibition against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli bacteria as well as demonstrated excellent antioxidant properties. Based on Franz cell analyses, the permeation flux of the drug from optimized formulations through mice skin was 92 (pH 5.5) and 110 (pH 7.4) μg/cm2·h−1. Moreover, hydrogel membranes retained significant amounts of drug in the skin for 24 h, such as 2371 (pH 5.5) and 3300 µg/cm2 (pH 7.4). Acute dermal irritation tests in rats showed that hydrogel membranes were nonirritating. Hydrogel membranes containing gallic acid could be an effective option for improving wound healing and could result in faster wound healing.

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Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing

Cited by 12 publications

References 19 publications

Exploring the association between a standardized extract of pequi peels (Caryocar brasiliense Cambess) and blue light as a photodynamic therapy for treating superficial wounds

Exploring the association between a standardized extract of pequi peels (Caryocar brasiliense Cambess) and blue light as a photodynamic therapy for treating superficial wounds

Synergestic effect of gallic acid lipid nanoparticles to improve the physiochemical property and cellular uptake against MDA MB 231 Cancer cell line: Apoptosis, signaling pathway and cytotoxicity

Gallic Acid-Loaded Sodium Alginate-Based (Polyvinyl Alcohol-Co-Acrylic Acid) Hydrogel Membranes for Cutaneous Wound Healing: Synthesis and Characterization

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