Formulation and Characterization of a Cream Containing &lt;i&gt;Terminalia chebula&lt;/i&gt; Extract

Akhtar, Naveed; Khan, Ali; Muhammad, Saleh; Ahmed, Mahmood Othman; Khan, Hasan; Rasool, Fatima; Saeed, Tariq

doi:10.1159/000335823

Cited by 15 publications

(9 citation statements)

References 9 publications

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“…After skin treatment with water-in-oil emulsion based cream loaded with hydroalcoholic extract of Terminalia chebula plant for eight weeks, reduced transepithelial water loss was observed. Moreover, there was decrease in skin melanin contents also [ 60 ]. These features could be due to the phenolic compounds present in extract.…”

Section: Phytoextract Loaded Creamsmentioning

confidence: 99%

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

Jadoon

Karim

Asad

et al. 2015

Oxidative Medicine and Cellular Longevity

137

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The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts. These formulations may serve as cosmeceuticals to protect skin against injurious effects of UVR. The botanicals studied for dermatologic use in cream form include Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matricaria chamomilla L., Moringa oleifera, Morus alba, Ocimum basilicum, Oryza sativa, Polygonum minus, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum, and Vitis vinifera. The observed anti-aging effects of cream formulations could be an outcome of a coordinating action of multiple constituents. Of numerous botanicals, the phenolic acids and flavonoids appear effective against UVR-induced damage; however the evidence-based studies for their anti-aging effects are still needed.

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Section: Phytoextract Loaded Creamsmentioning

confidence: 99%

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

Jadoon

Karim

Asad

et al. 2015

Oxidative Medicine and Cellular Longevity

137

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“…It has also been investigated in clinical studies for its antioxidant effects and reversing the effects of pollution-induced skin damage [33]. The water-soluble extract contains >60% hydrolysable tannins including chebulinic and chebulagic acids, both of which provide long-lasting antioxidant properties [34][35][36] and biological mechanisms, for example, anti-inflammatory and photoprotective effects, that prevent skin ageing and restore skintoning [37][38][39][40][41][42]. The photoprotective effects of Haritaki fruit extract have been demonstrated by others using normal human dermal fibroblasts (HDFs) [43].…”

Section: Discussionmentioning

confidence: 99%

Reduction of senescence‐associated secretory phenotype and exosome‐shuttled miRNAs by Haritaki fruit extract in senescent dermal fibroblasts

Bogdanowicz

Roullet

Bensadoun

et al. 2023

Intern J of Cosmetic Sci

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Objective: Skin ageing is linked to the accumulation of senescent cells and a "senescence-associated secretory phenotype" (SASP). SASP factors include chemokines, cytokines, and small extracellular vesicles (EVs) containing miR-NAs. We characterized SASP profile markers in normal human dermal fibroblasts (HDFs) and evaluated the effect of Haritaki fruit extract on these senescence markers.Methods: Senescence was induced in HDFs by ionizing radiation (X ray), followed by 14 days of culture. Parallel incubations included fibroblasts treated for 12 days with 10 or 100 μg/mL Haritaki (a standardized extract of Terminalia chebula fruit). Senescence was assessed on Day 14 according to cell morphology, βgalactosidase activity, RT-qPCR measurement of SASP genes, as well as semiquantitative (RT-qPCR) expression of miRNAs contained in EVs isolated from the medium. The size and distribution of EVs were measured by Nanoparticle Tracking Analysis.Results: Human dermal fibroblasts exhibited a senescent phenotype 14 days after ionizing-radiation, demonstrated by a flattened and irregular shape, increased βgalactosidase activity and over-expression of SASP genes. CSF3, CXCL1, IL1β, IL6 and IL8 genes were increased by 1492%, 1041%, 343%, 478%, 2960% and 293%, respectively. The cell cycle inhibitor, CDKN1A, was increased by 357%, while COL1A1, was decreased by 56% and MMP1 was increased by 293%. NTA analysis of the EVs size distribution indicated a mix of exosomes (45-100 nm) and microvesicles (100-405 nm). miRNA expression in EVs was increased in senescent fibroblasts. miR 29a-3p, miR 30a-3p, miR 34a-5p, miR 24a-3p and miR 186-5p were increased in senescent HDF by 4.17-, 2.43-, 1.17-, 2.01, 12.5-fold, respectively. Incubation of senescent fibroblasts with Haritaki extract strongly decreased SASP mRNA levels and miRNA expression in EVs. Conclusion:Haritaki strongly reduced SASP expression and EV-shuttled miR-NAs in senescent fibroblasts. These results indicate that Haritaki has strong senomorphic properties and may be a promising ingredient for the development How to cite this article:

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“…Numerous studies support multiple skin benefits of extracts prepared from the fruit of TC, from antioxidant, anti-inflammatory and anti-microbial effects to depigmentation, wound healing and rejuvenating effects. [18][19][20][21] However, many of the studies were performed using crude extracts prepared with non-aqueous or aqueousalcoholic solvents. This lies in sharp contrast to the study described here and previously reported that utilized a TC fruit extract prepared from a well-defined aqueous process that reliably yields high levels of the bioactive phytochemicals known to account for its biological properties.…”

Section: Discussionmentioning

confidence: 99%

Standardized Terminalia chebula Fruit Extract: A Natural Ingredient That Provides Long-Lasting Antioxidant Protection and Reverses Visible Signs of Pollution-Induced Skin Damage

Randhawa¹,

Meyer²,

Sachdev³

et al. 2021

CCID

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Background Identification of long-lasting natural antioxidants to protect against and repair skin damage induced by exposure to environmental pollution is in high demand. Objective To investigate a standardized Terminalia chebula (TC) fruit extract for its long-lasting antioxidant and anti-inflammatory properties and its ability to reverse the visible signs of pollution-induced skin damage in an 8-week clinical study. Material and Methods Chemical and cell-based in vitro studies were performed to characterize long-lasting antioxidant and anti-inflammatory properties; a clinical study with subjects with normal to dry skin living in a high-pollution city for the previous 5 years was conducted to assess if a formulation containing 1% standardized TC fruit extract affected significant improvements in skin’s visible condition and appearance compared with its placebo. Results The standardized TC fruit extract provided longer-lasting and more efficient neutralization of reactive oxygen species (ROS) than tocopherol; treatment of keratinocytes with the fruit extract prior to being stressed with urban dust safeguarded against increases in intracellular ROS, inhibited release of inflammatory cytokines IL-6 and IL-8 and protected membrane lipids against peroxidation. A clinical study yielded statistically significant improvements in dermatologist scores and subject self-assessments for skin texture, hydration, tone, firmness and radiance as compared to its placebo. Conclusion These studies validate the use of this standardized TC fruit extract not only as a restorative to diminish visible signs of existing damage but also as a preventative to help defend skin against damages caused by chronic exposure to environmental pollution.

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Formulation and Characterization of a Cream Containing <i>Terminalia chebula</i> Extract

Cited by 15 publications

References 9 publications

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity

Reduction of senescence‐associated secretory phenotype and exosome‐shuttled miRNAs by Haritaki fruit extract in senescent dermal fibroblasts

Standardized Terminalia chebula Fruit Extract: A Natural Ingredient That Provides Long-Lasting Antioxidant Protection and Reverses Visible Signs of Pollution-Induced Skin Damage

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