Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

Abstract

Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II. Triethanolamine-containing ternary composite of aceclofenac-poly(vinyl-pyrrolidone) nanofibers were formulated to exert the synergistic effect on the drug-dissolution improvement. The composition and the electrospinning parameters were changed to select the fibrous sample of optimum fiber characteristics. To determine the morphology of the nanofibers, scanning electron microscopy was used. Fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC) were applied for the solid-state characterization of the samples, while the drug release profile was followed by the in vitro dissolution test. The nanofibrous formulations had diameters in the range of few hundred nanometers. FT-IR spectra and DSC thermograms indicated the amorphization of aceclofenac, which resulted in a rapid release of the active substance. The characteristics of the selected ternary fiber composition (10 mg/g aceclofenac, 1% w/w triethanolamine, 15% w/w PVPK90) were found to be suitable for obtaining orally dissolving webs of fast dissolution and potential oral absorption.

Microstructure of Ni0.5Zn0.5Fe2O4 Nanofiber with Metal Nitrates in Electrospinning Precursor

“…The DTA peak is located at around 200 °C, and can be explained by the glass transition of the PVP. The known glass transition temperature of pure PVP is from 180 °C to 200 °C, and close to the secondary DTA peak [ 27 ]. The thermal reaction temperature is variable due to the molecular weight of PVP and the nitrate input.…”

Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets

“…At 3400 cm −1 , the characteristic peak of the -OH group and its H-bonds was observed [41], which might result from a keto-amide equilibrium or the absorbed water of the powder. The peaks at 1650 cm −1 derived from the carbonyl of the pyrrolyl ring [42].…”

Scale‐up of electrospinning technology: Applications in the pharmaceutical industry

“…During the past decade, the number of publications dealing with electrospun drug delivery systems increased exponentially. Laboratory‐scaled ES has been used for antibiotics (Zupančič et al, ), wound dressings (Tamm et al, ), antifungal (Veras, Roggia, Pranke, Pereira, & Brandelli, ), anti‐allergic (Abdelhakim, Coupe, Tuleu, Edirisinghe, & Craig, ), anti‐inflammatory (Sipos, Kósa, Kazsoki, Szabó, & Zelkó, ), and anticancer drugs (Liu et al, ; Ma et al, ), and so on. The reader is directed to excellent and detailed reviews for further information on this topic (Chen, Li, Li, & Xie, ; Ding et al, ; Hu et al, ; Kajdič, Planinšek, Gašperlin, & Kocbek, ; Qi & Craig, ; Sebe, Szabó, Kállai‐Szabó, & Zelkó, ; Seeram, Zamani, & Molamma, ; Sill & von Recum, ; Topuz & Uyar, ).…”