Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery

Song, Cuxian; Labhasetwar, Vinod; Murphy, Hedwig S.; Qu, Xuanhui; Humphrey, William R.; Shebuski, Ronald J.; Levy, Robert J.

doi:10.1016/s0168-3659(96)01484-8

Cited by 334 publications

(180 citation statements)

References 34 publications

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“…Biodegradable polyesters such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) have been widely used for the controlled delivery of polypeptides and proteins in the format of microspheres or nanospheres [20][21][22][23][24][25]. The release kinetics can be modulated by adjusting the factor loading, polymer molecular weight, lactide / glycolide ratio in the copolymer, and formulation methods [21,23,26,27].…”

Section: Introductionmentioning

confidence: 99%

Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB

Wei

Jin

Giannobile

et al. 2006

Journal of Controlled Release

205

157

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The localized and temporally controlled delivery of growth factors is key to achieving optimal clinical efficacy. In sophisticated tissue engineering strategies, the biodegradable scaffold is preferred to serve as both a three-dimensional (3-D) substrate and a growth factor delivery vehicle to promote cellular activity and enhance tissue neogenesis. This study presents a novel approach to fabricate tissue engineering scaffolds capable of controlled growth factor delivery whereby growth factor containing microspheres were incorporated into 3-D scaffolds with good mechanical properties, wellinterconnected macroporous and nano-fibrous structures. The microspheres were uniformly distributed throughout the nano-fibrous scaffold and their incorporation did not interfere the macro-, micro-, and nanostructures of the scaffold. The release kinetics of platelet-derived growth factor-BB (PDGF-BB) from microspheres and scaffolds was investigated using poly(lactic-co-glycolic acid) (PLGA50) microspheres with different molecular weights (6.5 and 64kDa, respectively) and microsphere-incorporated poly(L-lactic acid) (PLLA) nano-fibrous scaffolds. Incorporation of microspheres into scaffolds significantly reduced the initial burst release. Sustained release from several days to months was achieved through different microspheres in scaffolds. Released PDGF-BB was demonstrated to possess biological activity as evidenced by stimulation of human gingival fibroblast DNA synthesis in vitro. The successful generation of 3-D nano-fibrous scaffold incorporating controlled-release factors indicates significant potential for more complex tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB

Wei

Jin

Giannobile

et al. 2006

Journal of Controlled Release

205

157

View full text Add to dashboard Cite

show abstract

“…This methodology has been applied to a diverse range of lipophilic drugs (Juni et al, 1985;Kim et al, 2005;Ruan and Feng, 2003), however as such is not suitable for the encapsulation of hydrophilic drugs and biomolecules (Jalil and Nixon, 1990). Modifications to the emulsion-solvent evaporation technique have enabled successful entrapment and subsequent release of proteins and other hydrophilic compounds (Aguiar et al, 2004;Crotts and Park, 1995;Gaspar et al, 1998;Song et al, 1997;Zhang and Zhu, 2004). The multiple emulsionsolvent evaporation methodology (Ogawa et al, 1988) involves preparing an internal water-in-oil (w 1 /o) emulsion, where the inner aqueous phase contains the chosen hydrophilic active and the oil phase the selected polymer and appropriate surfactant.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation and release ofα-chymotrypsin from poly(glycerol adipate-co-ω-pentadecalactone) microparticles

Gaskell¹,

Hobbs²,

Rostron³

et al. 2008

Journal of Microencapsulation

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Polymer based microparticles are increasingly becoming of interest for a variety of applications including drug delivery. Recently poly(glycerol adipate) (PGA) and poly(glycol adipate-co--pentadecalactone) have shown promise for delivery of dexamethasone phosphate and ibuprofen. In this paper the copolyester poly(glycol adipate-co--pentadecalactone) was evaluated as a colloidal delivery system for encapsulated therapeutic proteins. Enzyme containing microparticles were prepared via the double water-in-oil-in-water (w/o/w) emulsion-solvent evaporation methodology. -chymotrypsin was used as a model proteolytic enzyme and its transfer was monitored during the emulsification process, in addition to in vitro release from formed particles. On average 22.1g protein per 1mg polymer was encapsulated, although gradual loss of activity of the protein, once released, was recorded. The work presented shows the potential of this polyester as a delivery system for enzymes via microparticles, with improvements to the system achievable via polymer and process optimisation. The pendant hydroxyl groups on the polymer backbone provide future capacity for tailored alteration of the physical and chemical properties of the polymer, in addition to covalent attachment of various compounds.

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“…Magenheim et al (1993), and Sanchez et al (1993) have reported that fine particles displayed more rapid initial release drug than coarser ones due to their larger surface area per unit mass because more drug molecules are loaded onto the outer particle surfaces. Also, since aspirin is soluble in aqueous media, upon in vitro test, aspirin is dissolved rapidly into the release medium giving rise to the burst release effect observed, which also has been reported (Rodrigues et al 1995;Peracchia et al 1997;Song et al 1997).…”

Section: Figmentioning

confidence: 64%

Formulation of Fe₃O₄/Acrylate Co-Polymer Nanocomposites as Potential Drug Carriers

Phanapavudhikul

Shen

et al. 2008

Drug Delivery

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Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery

Cited by 334 publications

References 34 publications

Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB

Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB

Encapsulation and release ofα-chymotrypsin from poly(glycerol adipate-co-ω-pentadecalactone) microparticles

Formulation of Fe₃O₄/Acrylate Co-Polymer Nanocomposites as Potential Drug Carriers

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Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery

Cited by 334 publications

References 34 publications

Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB

Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB

Encapsulation and release ofα-chymotrypsin from poly(glycerol adipate-co-ω-pentadecalactone) microparticles

Formulation of Fe3O4/Acrylate Co-Polymer Nanocomposites as Potential Drug Carriers

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Formulation of Fe₃O₄/Acrylate Co-Polymer Nanocomposites as Potential Drug Carriers