Formulation and Characterization of Bovine Serum Albumin-Loaded Niosome

Moghassemi, Saeid; Omidfar, Kobra

doi:10.1208/s12249-016-0487-1

Cited by 61 publications

(47 citation statements)

References 34 publications

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“…The authors found that both nanoparticles resulted in higher IgG in serum from BSA compared to the controls, but that niosomes were generally more effective than liposomes. A follow‐up study was performed by Omidfar and co‐workers to optimize the release rate of BSA from niosomes . Most recently, Bhatnagar and co‐workers developed niosomes to deliver protective antigens for immunization against an anthrax spore challenge in mice .…”

Section: Microscale Materials For Immunotherapymentioning

confidence: 99%

“…A follow-up study was performed by Omidfar and co-workers to optimize the release rate of BSA from niosomes. [363] Most recently, Bhatnagar and co-workers developed niosomes to deliver protective antigens for immunization against an anthrax spore challenge in mice. [364] While there are still relatively few examples of niosomes used in immunotherapy, we believe this is an auspicious vehicle for translation due to its immunogenic performance, scale and ease of formulation, and low cost.…”

Section: Niosomesmentioning

confidence: 99%

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Materials for Immunotherapy

et al. 2019

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Breakthroughs in materials engineering have accelerated the progress of immunotherapy in preclinical studies. The interplay of chemistry and materials has resulted in improved loading, targeting, and release of immunomodulatory agents. An overview of the materials that are used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. The materials are organized based on their characteristic length scale, whereby the enabling feature of each technology is organized by the structure of that material. For example, the mechanisms by which i) nanoscale materials can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) microscale materials can facilitate cell‐mediated transport and serve as artificial antigen‐presenting cells, and iii) macroscale materials can form the basis of artificial microenvironments to promote cell infiltration and reprogramming are discussed. As a step toward establishing a set of design rules for future immunotherapies, materials that intrinsically activate or suppress the immune system are reviewed. Finally, a brief outlook on the trajectory of these systems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and autoimmunity is presented.

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Section: Microscale Materials For Immunotherapymentioning

confidence: 99%

Section: Niosomesmentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

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“…Firstly, a formulation optimization study was conducted and BSA release properties of niosomes determined. This investigation additionally showed a cost-effective method for BSA quantification in niosomes and similar vesicles (8). Secondly, similar span 60 and cholesterol niosomes were loaded with basic fibroblast growth factor, incorporated in agarose hydrogel as a scaffold, and evaluated for their in vitro cell proliferation performance (9).…”

mentioning

confidence: 92%

“…In an alternative approach for macromolecule drug formulation in nanostructured systems, two articles detail the development and characterization of niosomes as delivery systems (8,9). Firstly, a formulation optimization study was conducted and BSA release properties of niosomes determined.…”

mentioning

confidence: 99%

Formulation and Delivery of Macromolecules

Morales

2016

AAPS PharmSciTech

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The field of macromolecule drug development (also known in the literature as biologics, biomacromolecules, and biotechnology drugs) has sharply grown over the past 15 years (1). With a steady growth in total sales, sales per drug type (i.e., therapeutic proteins and peptides, monoclonal antibodies, or vaccines), and innovation, macromolecule drug development continues to make a strong case in contrast with small-molecule drugs (2,3). While most marketed products and clinical trials on macromolecule drugs are injectable dosage forms, there is a drive for more convenient dosage forms evidenced in the body of scientific literature, numerous clinical trials, and a handful of successful products for alternative routes of administration.While extravascular administration has been widely investigated and has shown potential, there are many difficulties associated with absorption of therapeutic macromolecules into the body. For example, oral delivery of macromolecules for intestinal absorption faces a number of well-known limitations including instability in gastric pH, proteolytic enzyme content in the upper gastrointestinal (GI) tract, and insufficient permeation and bioavailability; therefore, encapsulation, targeted release, and novel permeation enhancers have been a focus area of research (4). With the difficulties of GI tract absorption, alternative routes of delivery have also been investigated, including buccal/sublingual, transdermal, and nasal/pulmonary. This special theme of AAPS PharmSciTech explores specific aspects in the state of the art in macromolecule delivery and showcases innovative research strategies intended to improve absorption and performance of dosage forms containing macromolecular drugs.In our review in this Themed Edition, Montenegro-Nicolini and Morales describe the major advancements in mucoadhesive films as dosage forms for buccal administration of macromolecule drugs (5). The review presents the stratified mucosal epithelium as an absorption barrier and introduces strategies to enhance macromolecule permeation. The authors identify solvent casting as the conventional choice for film development; however, recent advancements in hot melt extrusion (6) and inkjet printing (7) could provide new avenues for buccal film product development.Hot melt extrusion of solid dosage forms for macromolecule drug development has been avoided in the past due to potential drug degradation due to the high temperatures and shear achieved during the process. Nonetheless, efforts in using low-glass transition temperature polymers and optimized processing conditions have shown promise. In their article, Cossé et al. focus on systematically investigating all relevant extrusion variables as well as using a lowtemperature processing polymer (6). After suitable formulation development, the authors showed that the extruded implants were able to sustain bovine serum albumin (BSA) release for weeks while maintaining very limited conformation changes in the BSA structure.In an alternative approach for macromolecule dr...

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“…Moghassemi et al [124] formulated bovine serum albumin-loaded niosomes that have potential use in pharmaceutical and cosmetic applications.…”

Section: Other Applicationsmentioning

confidence: 99%

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

et al. 2017

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Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to diseased sites. Various types of drug-delivery systems utilize carriers, such as immunoglobulins, serum proteins, synthetic polymers, liposomes, and microspheres. The vesicular system of niosomes, with their bilayer structure assembled by nonionic surfactants, is able to enhance the bioavailability of a drug to a predetermined area for a period. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Other additives, such as cholesterol, can be used to maintain the rigidity of the niosomes' structure. This narrative review describes fundamental aspects of niosomes, including their structural components, methods of preparation, limitations, and current applications to various diseases.

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Formulation and Characterization of Bovine Serum Albumin-Loaded Niosome

Cited by 61 publications

References 34 publications

Materials for Immunotherapy

Materials for Immunotherapy

Formulation and Delivery of Macromolecules

Niosomes: a review of their structure, properties, methods of preparation, and medical applications

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