Formulation and characterization of floating biphasic tablet consisting of cefdinir nanosuspension

Abstract

Cefdinir (Cef) is a third-generation cephalosporin antibacterial agent with an extended spectrum and low solubility and permeability. In this study, cefdinir was prepared as nanosuspension and lyophilized to powder. The lyophilized cefdinir was further processed to develop a bilayer tablet. By utilizing the bilayer approach, the first therapeutic action is impacted by the immediate part's rapid disintegration and a prolonged release from the floating part is achieved. Floating system ensures a recognized extended-release in the gastric medium and avoids the numerous daily dosages. Different polymers were utilized with effervescent materials in different concentrations. The method employed in preparing tablets is direct compression. Every formulation undergoes through standard pre and post-compression floating tablet characteristics with unique results that allow for further comparison between various formulations and increase our understanding of the makeup of medications, polymers, additives, and preparation technique. The formula NFT8 was selected as the best formulation design. It contains (HPMC K4M 400 mg, Carbapol940 50 mg, sodium bicarbonate 100 mg, and citric acid 75 mg) and provided efficient floating characteristics for more than 24 hr as revealed by in vitro dissolution release.

Formulation and Evaluation of Immediate-Release Tablet Containing Atorvastatin Phospholipid Solid Dispersion

“…It can be described as the powder's capacity to decrease in volume when subjected to pressure. Carr's index can be calculated by using the equation provided below (30).…”