Formulation and characterization of microemulsions based on mixed nonionic surfactants and peppermint oil

Fanun, Monzer

doi:10.1016/j.jcis.2009.12.008

Cited by 61 publications

(25 citation statements)

References 51 publications

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“…Mathew et al [10] observed that percolation threshold is altered by small additives concentrations such as cholesterol or gramicidin [5]. These findings have been confirmed by literature during the last decade [11][12][13][14]. In support of this, we can say that percolation is not a consequence of bicontinuous structures presented in the medium, because the structure of discrete droplets is not changed [5].…”

Section: Introductionsupporting

confidence: 52%

Influence of Amphiphiles on Percolation of AOT-Based Microemulsions Prediction Using Artificial Neural Networks

Astray¹,

Cid²,

Moldes³

et al. 2017

Properties and Uses of Microemulsions

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In this chapter, the ability of artificial neural networks was evaluated to predict the influence of amphiphiles as additive upon the electrical percolation of dioctyl sodium sulfosuccinate (AOT)/isooctane/water microemulsions. In particular, water/AOT/isooctane microemulsion behaviour has been modelled. These microemulsions have been developed in presence of 1-n-alcohols, 2-n-alcohols, n-alkylamines and n-alkyl acids. In all cases, a neural network has been obtained to predict with accuracy the experimental behaviour to identify the physico-chemical variables (such as additive concentration, molecular mass, log P, pK a or chain length) that exert a greater influence on the model. All models are valuable tools to evaluate the percolation temperature for AOT-based microemulsions.

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Section: Introductionsupporting

confidence: 52%

Influence of Amphiphiles on Percolation of AOT-Based Microemulsions Prediction Using Artificial Neural Networks

Astray¹,

Cid²,

Moldes³

et al. 2017

Properties and Uses of Microemulsions

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show abstract

“…4,5) Investigations of microemulsions composed by eucalyptus/peppermint oil and water were reported to have many potential applications. 6,7) Lipid-based systems such as microemulsions, nanoemulsions, solid lipid nanoparticles, and liposomes were recently applied to transdermal drug delivery. 8) Microemulsions are single phase, optically isotropic nano-structured solutions composed of a surfactant, cosurfactant, oil, and water.…”

mentioning

confidence: 99%

Development and Characterization of Eucalyptol Microemulsions for Topic Delivery of Curcumin

Liu

Chang

2011

Chem. Pharm. Bull.

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Transdermal drug delivery has many advantages over other administration routes: for example, avoidance of hepatic metabolism, convenient administration for the patient, and easy withdrawal of treatment if necessary. Despite extensive studies of transdermal drug delivery, only a few drug formulations are commercially available. 1) One of the reasons for this is the permeation barrier by the stratum corneum to exogenous substances. Skin penetration enhancement can be chieved using appropriate physical and chemical means to overcome the skin's barrier function. Chemical penetration enhancers such as fatty acids, fatty esters, surfactants, and terpenes have received considerable attention due to their low cost, ease of use, safety, and efficacy.2) Terpenes are lipophilic ingredients of essential oils which can disturb intracellular lipids and increase the fluidization of the stratum corneum, thereby enhancing drug penetration.3) Eucalyptus oil (eucalyptol, a terpene from trees) was adopted as the oil phase to design transdermal vehicles for various drugs including estradiol, progesterone, cyproterone acetate, finasteride, and hydrocortisone. 4,5) Investigations of microemulsions composed by eucalyptus/peppermint oil and water were reported to have many potential applications.6,7) Lipid-based systems such as microemulsions, nanoemulsions, solid lipid nanoparticles, and liposomes were recently applied to transdermal drug delivery. 8) Microemulsions are single phase, optically isotropic nano-structured solutions composed of a surfactant, cosurfactant, oil, and water. The ability of microemulsions to deliver drugs through a transdermal route in a controlled manner was recently reviewed. 9) Advantages of microemulsion delivery systems include spontaneous formation, easy preparation, low viscosity, high surface area, high drug solubilization, optical transparency, and thermodynamic stability.10) Microemulsions were applied to deliver different lipophilic drugs including fluconazole, 11) penciclovir, 12) quercetin, 13) diclofenac, 14) and progesterone 15) through the transdermal route. Those in vitro and in vivo studies demonstrated that lipophilic drugs incorporated into microemulsions can efficiently penetrate the skin.Curcumin and curcuminoids are yellow polyphenolic compounds extracted from the spice turmeric (Curcuma longa). Recent studies demonstrated that curcumin has the potential to protect skin by reducing inflammation through nuclear factor (NF)-kB inhibition and to reduce wound-healing time by improving collagen deposition.16) Curcumin can regenerate muscle cells after traumatic injury by modulating NF-kB activity within muscle tissues. Additionally, the use of curcumin for the chemoprevention and treatment of various skin diseases like scleroderma, psoriasis, and skin cancer was reviewed.16) Patel et al. demonstrated that curcumin-containing films have good anti-inflammatory activity against carrageenan-induced edema in rats similar to a standard formulation through the transdermal route.17) Those studies sugg...

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“…All formulations contained purified water as hydrophilic phase. The diagrams were built according to the method described by Fanun [12,13].…”

Section: Determination Of the Ternary Phase Diagram And Preparation Omentioning

confidence: 99%

Development of Microemulsion Dermal Products Based on Avocado Oil for Topical Administration

Ochiuz¹,

Hortolomei²

2017

Properties and Uses of Microemulsions

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The research described in this study aimed at developing microemulsions for dermal application using avocado oil. Due to its composition, avocado oil helps maintaining the barrier function of the skin. It has a nutritional effect on the skin, and it reduces the intensity of the process of skin peeling. Various surfactant:cosurfactant systems were tested in the conducted studies. There were no significant differences between the diagrams generated by Tween 20 and the surfactant:cosurfactant system, Tween 20:PEG400, at a ratio of 1:1. Six formulations were selected from the dilution line 7 of the ternary phase diagrams obtained by using as a surfactant Tween 20 and Tween 20:PEG 400, respectively. The formulations were characterized by determining physicochemical properties specific. In the next phase of study, these six formulations were used as a vehicle for incorporating erythromycin in order to develop erythromicyn incorporated formulations for topical administration. The quality control of microemulsions with erythromycin was performed by evaluating the physical chemical, organoleptic and sensorial properties. Microemulsions were pharmacotechnically characterized by assessing the in vitro and ex vivo release kinetics of erythromycin.

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Formulation and characterization of microemulsions based on mixed nonionic surfactants and peppermint oil

Cited by 61 publications

References 51 publications

Influence of Amphiphiles on Percolation of AOT-Based Microemulsions Prediction Using Artificial Neural Networks

Influence of Amphiphiles on Percolation of AOT-Based Microemulsions Prediction Using Artificial Neural Networks

Development and Characterization of Eucalyptol Microemulsions for Topic Delivery of Curcumin

Development of Microemulsion Dermal Products Based on Avocado Oil for Topical Administration

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